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Multiple sclerosis (MS) is a debilitating neurological disease associated with a variety of psychological, cognitive, and motoric symptoms. Walking is among the most important functions compromised by MS. Dual-task walking (DTW), an everyday activity in which people walk and engage in a concurrent, discrete task, has been assessed in MS, but little is known about how it relates to other MS symptoms. Self-awareness theory suggests that DTW may be a function of the interactions among psychological, cognitive, and motor processes.
Cognitive testing, self-report assessments for depression and falls self-efficacy (FSE), and walk evaluations [DTW and single-task walk (STW)] were assessed in seventy-three people with MS in a clinical care setting. Specifically, we assessed whether psychological factors (depression and FSE) that alter subjective evaluations regarding one’s abilities would moderate the relationships between physical and cognitive abilities and DTW performance.
DTW speed is related to diverse physical and cognitive predictors. In support of self-awareness theory, FSE moderated the relationship between STW and DTW speeds such that lower FSE attenuated the strength of the relationship between them. DTW costs – the change in speed normalized by STW speed – did not relate to cognitive and motor predictors. DTW costs did relate to depressive symptoms, and depressive symptoms moderated the effect of information processing on DTW costs.
Findings indicate that an interplay of physical ability and psychological factors – like depression and FSE – may enhance understanding of walking performance under complex, real-world, DTW contexts.
To improve maternal health outcomes, increased diversity is needed among pregnant people in research studies and community surveillance. To expand the pool, we sought to develop a network encompassing academic and community obstetrics clinics. Typical challenges in developing a network include site identification, contracting, onboarding sites, staff engagement, participant recruitment, funding, and institutional review board approvals. While not insurmountable, these challenges became magnified as we built a research network during a global pandemic. Our objective is to describe the framework utilized to resolve pandemic-related issues.
We developed a framework for site-specific adaptation of the generalized study protocol. Twice monthly video meetings were held between the lead academic sites to identify local challenges and to generate ideas for solutions. We identified site and participant recruitment challenges and then implemented solutions tailored to the local workflow. These solutions included the use of an electronic consent and videoconferences with local clinic leadership and staff. The processes for network development and maintenance changed to address issues related to the COVID-19 pandemic. However, aspects of the sample processing/storage and data collection elements were held constant between sites.
Adapting our consenting approach enabled maintaining study enrollment during the pandemic. The pandemic amplified issues related to contracting, onboarding, and IRB approval. Maintaining continuity in sample management and clinical data collection allowed for pooling of information between sites.
Adaptability is key to maintaining network sites. Rapidly changing guidelines for beginning and continuing research during the pandemic required frequent intra- and inter-institutional communication to navigate.
This article explores the relationship between a distinctive early modern city, Boston, Massachusetts, and the dramatic expansion of the production and consumption of intoxicants in the emergent Atlantic world. In particular, it attempts to draw together two strands of Boston's history seldom considered together: its origins as an aspirational settlement of English puritans aiming to build a godly city, and the deep involvement of its merchants and consumers in the overseas trade in intoxicants – tobacco, sugar, rum, wine, coffee, tea, chocolate, and others. By considering the cultures of consumption associated with godliness alongside other clusters of consumption in which intoxicants also played a part, it attempts to open new avenues for thinking about the many ways in which new forms and objects of desire transformed the economy and material culture of early modernity.
Very little is known about the risk of developing psychological morbidities among adults living with cerebral palsy (CP) or spina bifida (SB). The objective of this study was to compare the incidence of and adjusted hazards for psychological morbidities among adults with and without CP or SB.
Privately insured beneficiaries were included if they had an International Classification of Diseases, Ninth revision, Clinical Modification diagnostic code for CP or SB (n = 15 302). Adults without CP or SB were also included (n = 1 935 480). Incidence estimates of common psychological morbidities were compared at 4-years of enrollment. Survival models were used to quantify unadjusted and adjusted hazard ratios for incident psychological morbidities.
Adults living with CP or SB had a higher 4-year incidence of any psychological morbidity (38.8% v. 24.2%) as compared to adults without CP or SB, and differences were to a clinically meaningful extent. Fully adjusted survival models demonstrated that adults with CP or SB had a greater hazard for any psychological morbidity [hazard ratio (HR): 1.60; 95% CI 1.55–1.65], and all but one psychological disorder (alcohol-related disorders), and ranged from HR: 1.32 (1.23, 1.42) for substance disorders, to HR: 4.12 (3.24, 5.25) for impulse control disorders.
Adults with CP or SB have a significantly higher incidence of and risk for common psychological morbidities, as compared to adults without CP or SB. Efforts are needed to facilitate the development of improved clinical screening algorithms and early interventions to reduce the risk of disease onset/progression in these higher-risk populations.
We conclude by arguing that White animus toward Latinos can no longer be ignored. The policy implications violent the rights of both Latinos as well as undermine the very foundation of democratic government. The future of Latinos living in the United States is largely dependent on how citizens and political institutions deal with this widespread and influential animus toward Latinos. We suggest that that this animus will most likely be a persistent presence in US politics, but can be muted when policy agendas shift and the electoral benefits of campaigning toward those who harbor this animus subside.
Measuring racial animus is quite difficult in an era where explicit racism is still deemed socially unacceptable. This chapter shows that existing measures of racism toward Latinos fail to capture the full extent of animosity toward the group and limits our understanding of how White animus toward Latinos shapes American politics. It provides a wide range of both focus group and survey data to document how White’s commonly express animus about Latinos in everyday discourse. Evidence is provided that shows that this form of animus represents a coherent belief system that is distinct from other beliefs such as political ideology, a preference for Anglo-American culture, ethnocentrism, and old-fashioned racial stereotypes. The connection between this belief system and concerns about race is then established.
Immigration has become the most obvious point of contention between Whites and Latinos. Despite claims that anti-immigration sentiment is divorced of racism, this chapter demonstrates a sizable and stable relationship between White animus toward Latinos and public support for immigration policies ranging from a pathway to citizenship to Deferred Action for Childhood Arrivals to building a wall. Even Whites who are open to the idea of free migration for US citizens oppose the policy when applied to citizens of Latino countries as a result of this belief system that Latinos fail to assimilate and adhere to Anglo-American norms.