To send content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about sending content to .
To send content items to your Kindle, first ensure email@example.com
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about sending to your Kindle.
Note you can select to send to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Hardening of the zona pellucida is thought to be influenced by suboptimal culture of embryos in vitro, advancing age in vivo, duration of hormonal stimulation during in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI), and smoking. There is some evidence that embryos that have undergone zona manipulation for assisted hatching (AH) tend to implant one day earlier than unhatched embryos. The author's group conducted a Cochrane review in 2003 which was updated in 2007 to determine whether AH of embryos following assisted conception improved live birth and clinical pregnancy rates. The primary outcome measure was live birth rate per woman randomized, as this reflects the take home baby rate that is crucial to any assisted reproduction technology (ART). Significant improvement in clinical pregnancy rate was seen independent of the degree of AH, be it thinning, drilling a small hole in the zona or complete zona removal.
Email your librarian or administrator to recommend adding this to your organisation's collection.