We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure coreplatform@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Contestation over the structure and location of final sovereign authority—the right to make and enforce binding rules—occupies a central role in political development. Historically, war often settled these debates and institutionalized the victor’s vision of sovereignty. Yet sovereign authority requires more than institutions; it ultimately rests on the recognition of the governed. How does war shape imagined sovereignty? We explore the effect of warfare in the United States, where the debate over two competing visions of sovereignty erupted into the American Civil War. We exploit the grammatical shift in the “United States” from a plural to a singular noun as a measure of imagined sovereignty, drawing upon two large textual corpuses: newspapers (1800–99) and congressional speeches (1851–99). We demonstrate that war shapes imagined sovereignty, but for the North only. Our results further suggest that Northern Republicans played an important role as ideational entrepreneurs in bringing about this shift.
There are many factors causing the shimmy of the aircraft landing gear and structural clearance of landing gear is a typical factor. Some aircraft in service or operation did not shimmy before, but suddenly appeared after a period of use. To solve the problem of clearance shimmy during the service of a certain aircraft, we established a dynamic model of rotating gear with clearance based on the flexible multi-body dynamics model of landing gear and L-N contact theory. We defined different types of clearance and established a mechanical model of aircraft pendulum vibration considering the clearance of landing gear structure for dynamic simulation, and studied the effects of different clearance types, clearance size of motion pair and different clearance positions on the stability of pendulum. The results show that the axial clearance has little effect on the shimmy performance of landing gear; the radial clearance has a certain effect on the shimmy performance of medium speed running, which slightly improves the shimmy damping required by medium speed running; the rotational clearance affects the shimmy performance of the nose landing gear by affecting the force transmission of structural components. The required shimmy damping coefficient increases at low speed and decreases at high speed. The main reason for the return clearance is that during the return, the shimmy damper does not work, which leads to the decrease of the shimmy damping performance and the increase of the required shimmy damping coefficient in the whole speed range. Meanwhile, the structural clearance will increase the shimmy frequency of the nose landing gear. By analysing the yaw angle of the nose landing gear and the time domain curve of the yaw angle of the yaw damper, we can determine which structure of the landing gear and which type of clearance is the cause of the yaw. Finally, the coupling effect caused by the main structural parameters of the landing gear in “gap shimmy” was analysed according to different mechanical stability distances and strut stiffness of the nose landing gear, providing reference for aircraft anti-shimmy design, nose landing gear fault diagnosis and nose landing gear maintenance support.
China plays a critical role in global biodiversity conservation, as both a biodiversity hotspot and for its role in international and domestic animal trade. Efforts to promote wildlife conservation have sparked interest in the attitudes held by Chinese citizens towards animals. Using a questionnaire, we sought to investigate the attitudes of 317 Chinese nationals across 22 provincial-level administrative units regarding their uses of animals, their perceived emotional capacities and views on exotic pets. We reduced the variables related to perceived uses of animals via Principal Component Analysis and ran Generalised Linear Models and Structural Equation Modelling to test relationships between questionnaire-derived variables. Perceptions of animals were divided into two Kellert categories — Utilitarian and Humanistic uses — and 97% of participants believed in animals’ capacities to have and express emotions. We found few interactions, with exotic pets, ie playing with or taking photographs, but the acceptability of owning an exotic pet influenced the likelihood of purchasing one. A belief that animals express emotions encouraged people to look for them as pets but thinking that pets make people happy made exotic pet ownership less acceptable. The shift in attitudes to include humanistic perceptions of animals, a belief in animals as emotive beings and understanding of terminology changed from the previous utilitarian views of pre-reform China, suggesting a readiness to embrace further conservation efforts in China. This deeper understanding of Chinese attitudes toward animals and drivers of the exotic pet trade within China may enable conservation efforts to better target future campaigns.
Plasma jets are widely investigated both in the laboratory and in nature. Astrophysical objects such as black holes, active galactic nuclei and young stellar objects commonly emit plasma jets in various forms. With the availability of data from plasma jet experiments resembling astrophysical plasma jets, classification of such data would potentially aid in not only investigating the underlying physics of the experiments but also the study of astrophysical jets. In this work we use deep learning to process all of the laboratory plasma images from the Caltech Spheromak Experiment spanning two decades. We found that cosine similarity can aid in feature selection, classify images through comparison of feature vector direction and be used as a loss function for the training of AlexNet for plasma image classification. We also develop a simple vector direction comparison algorithm for binary and multi-class classification. Using our algorithm we demonstrate 93 % accurate binary classification to distinguish unstable columns from stable columns and 92 % accurate five-way classification of a small, labelled data set which includes three classes corresponding to varying levels of kink instability.
Over the past decade, there have been massive developments in web-based and internet technologies, along with the introduction of smartphones. Smartphones represent a new generation of mobile technology that has fundamentally changed telecommunications (Abboudi and Amin 2011). They are equipped with immense computing capabilities that allow constant access to the internet and they enable more than just voice- and text-based communication. Smartphones are generally regarded as handheld computers rather than merely mobile telephones (Abboudi and Amin 2011). The release of Apple’s iPhone in 2007 most likely sparked a revolution in the telecommunications and information technology arena. The launch of the Apple App Store in July 2008 is also regarded as a pivotal moment in the advancement of smartphone technologies (Payne et al. 2012). The store enables users to download smartphone-based applications (apps) – computer programs that give smartphones capabilities and functions beyond accessing the internet.
To obtain the optimal solution for the performance of the turbofan engine using infrared stealth technology, an engine mathematical model with a backward infrared radiation intensity calculation module was established. The effects of infrared suppression measures on the performance of turbofan engines were analysed. Based on the multi-objective particle swarm optimisation (MOPSO) algorithm, the optimal solution for the performance in the cruise state of the reference engine refitted with the infrared radiation suppression module was obtained; Further, through the multiple design points (MDPs) concept, the thermal cycle optimisation design of the turbofan engine was carried out. The results show that the integrated fully shielded guiding strut (IFSGS) with air film cooling had the ideal infrared suppression effect. Compared with the reference engine refitted with infrared radiation suppression module, the engine after cycle optimisation design could obtain better infrared stealth performance.
The response to the COVID-19 pandemic in long-term care (LTC) has threatened to undo efforts to transform the culture of care from institutionalized to de-institutionalized models characterized by an orientation towards person- and relationship-centred care. Given the pandemic’s persistence, the sustainability of culture-change efforts has come under scrutiny. Drawing on seven culture-change models implemented in Canada, we identify organizational prerequisites, facilitatory mechanisms, and frontline changes relevant to culture change that can strengthen the COVID-19 pandemic response in LTC homes. We contend that a reversal to institutionalized care models to achieve public health goals of limiting COVID-19 and other infectious disease outbreaks is detrimental to LTC residents, their families, and staff. Culture change and infection control need not be antithetical. Both strategies share common goals and approaches that can be integrated as LTC practitioners consider ongoing interventions to improve residents’ quality of life, while ensuring the well-being of staff and residents’ families.
The jetting behaviour and migratory characteristics of a laser-induced cavitation bubble in a rectangular channel are investigated both experimentally and numerically, for various combinations of the geometric and physical parameters of the system. High-speed photography is used to visualize the temporal development of the bubble shape, the formation of liquid jets during bubble collapse, and the bubble displacement in contact with the sidewalls of the channel during two oscillation cycles of the bubble. The bubble profiles, pressure contours and velocity vectors ambient to the bubble are obtained through numerical simulation results by using an Eulerian finite element method with a compressible liquid impact model. The jetting behaviour of the bubble varies between single jet formation and the formation of three liquid jets directed towards each wall of the channel. The numerical calculations indicate that the liquid jets directed towards the sidewalls of the channel reach maximum velocities of 100 m s−1 while the peak velocity of the liquid jet directed towards the channel endwall is about 55 m s−1. A small bubble generated close to a sidewall of the channel develops only a single inclined jet during collapse. Such jets can reach velocities of up to 110 m s−1. A bubble displacement in contact with the sidewalls of the channels of 350 μm was observed during the first two oscillation cycles for a bubble with a maximum diameter slightly smaller than the height of the channel. The results of our investigations are compared to previous results obtained in similar configurations.
Earth-contact mechanism (ECM), a type of mechanism to keep the system in contact with the earth and to move with the terrain changes. This paper uses the virtual equivalent parallel mechanism (VEPM) to convert the terrain data into the kinematical variables of the moving platform in the VEPM, and further analyzes the performance of the VEPM at each terrain point. Then, the comprehensive performance of the VEPM is chosen as the optimization goal, and a task-oriented dimensional optimization approach combined with the particle swarm algorithm and the neural network algorithm is proposed. This paper conducted a comparative experiment to verify the superiority of the new approach in optimizing the ECM’s comprehensive performance, whose performance analysis also can be applied into the layout design of the ECM. This paper proposed an analysis method to construct the ECM’s performance map based on the digital terrain map, which helps the control system and operator to make the optimal control decision.
Patients with major depressive disorder (MDD) with acute suicidal ideation or behavior (MDSI) require immediate intervention. Though oral antidepressants can be effective at reducing depressive symptoms, they can take 4–6 weeks to reach full effect.
Objectives
This study aimed to identify unmet needs in the treatment of patients with MDSI, specifically exploring the potential clinical benefits of rapid reduction of depressive symptoms.
Methods
A Delphi panel consisting of practicing psychiatrists (n=12) from the US, Canada and EU was conducted between December 2020–June 2021. Panelists were screened to ensure they had sufficient experience with managing patients with MDD and MDSI. Panelists completed two survey rounds, and a virtual consensus meeting.
Results
This research confirmed current unmet needs in the treatment of patients with MDSI.
Hopelessness, functional impairment, worsening of MDD symptoms, recurrent hospitalization and higher risk of suicide attempt were considered as key consequences of the slow onset of action of oral antidepressants.
Treatment with rapid acting antidepressant was anticipated by panelists to provide short-term benefit such as rapid reduction of core MDD symptoms which may contribute to shorter hospital stays and improved patient engagement/compliance, allowing for earlier interventions and improved patient outcomes. For long-term benefits, panelists agreed that improved daily functioning and increased trust/confidence in treatment options, constitute key benefits of rapid-acting treatments
Conclusions
There is need for rapid-acting treatments which may help address key unmet needs and provide clinically meaningful benefits driven by the rapid relief of depressive symptoms particularly in patients with MDSI.
Disclosure
SB, ED, KJ, MO’H, QZ, MM, MH, SR, JA and DZ are employees of Janssen and hold stock in Johnson & Johnson Inc. AN is currently employed by Neurocrine Biosciences Inc. RP is an employee of Adelphi Values PROVE hired by Janssen.
Postpartum and peripartum depression are debilitating disorders that impact the mother and their ability to care for their children’s emotional, social, and physical needs. Current treatments include psychotherapy, pharmacotherapy, and electroconvulsive therapy. These treatments are moderately effective or come with side effects that can negatively impact mother and child. As a result, many mothers view some treatments as unacceptable while pregnant or breastfeeding. Over the last decade, repetitive transcranial magnetic stimulation (rTMS) has shown promise as an effective and safe treatment option for postpartum and peripartum depression. However, little is known regarding people’s knowledge and attitudes towards this emerging technology, with no research assessing this in Canada.
Objectives
We aim to identify gaps in knowledge and to assess attitudes toward rTMS as a treatment for postpartum and peripartum depression in mental health professionals, patients, and the general public living in Canada.
Methods
A mixed methods study design will be employed. The qualitative portion will consist of individual semi-structured interviews. An inductive thematic analysis will be completed. The quantitative portion will consist of an anonymous, self-administered survey shared through REDCap. Focus groups with rTMS experts will be conducted to inform survey creation.
Results
No resulst at this time.
Conclusions
Understanding gaps in knowledge and attitudes toward rTMS is the first step toward ensuring that everyone is well informed and able to access safe and effective treatments. With limited treatment options available to a postpartum and/or peripartum depression patients being well informed on all treatments is crucial towards accessing treatments that best suit their needs.
We describe a new low-frequency wideband radio survey of the southern sky. Observations covering 72–231 MHz and Declinations south of
$+30^\circ$
have been performed with the Murchison Widefield Array “extended” Phase II configuration over 2018–2020 and will be processed to form data products including continuum and polarisation images and mosaics, multi-frequency catalogues, transient search data, and ionospheric measurements. From a pilot field described in this work, we publish an initial data release covering 1,447
$\mathrm{deg}^2$
over
$4\,\mathrm{h}\leq \mathrm{RA}\leq 13\,\mathrm{h}$
,
$-32.7^\circ \leq \mathrm{Dec} \leq -20.7^\circ$
. We process twenty frequency bands sampling 72–231 MHz, with a resolution of 2′–45′′, and produce a wideband source-finding image across 170–231 MHz with a root mean square noise of
$1.27\pm0.15\,\mathrm{mJy\,beam}^{-1}$
. Source-finding yields 78,967 components, of which 71,320 are fitted spectrally. The catalogue has a completeness of 98% at
${{\sim}}50\,\mathrm{mJy}$
, and a reliability of 98.2% at
$5\sigma$
rising to 99.7% at
$7\sigma$
. A catalogue is available from Vizier; images are made available via the PASA datastore, AAO Data Central, and SkyView. This is the first in a series of data releases from the GLEAM-X survey.
The great demographic pressure brings tremendous volume of beef demand. The key to solve this problem is the growth and development of Chinese cattle. In order to find molecular markers conducive to the growth and development of Chinese cattle, sequencing was used to determine the position of copy number variations (CNVs), bioinformatics analysis was used to predict the function of ZNF146 gene, real-time fluorescent quantitative polymerase chain reaction (qPCR) was used for CNV genotyping and one-way analysis of variance was used for association analysis. The results showed that there exists CNV in Chr 18: 47225201-47229600 (5.0.1 version) of ZNF146 gene through the early sequencing results in the laboratory and predicted ZNF146 gene was expressed in liver, skeletal muscle and breast cells, and was amplified or overexpressed in pancreatic cancer, which promoted the development of tumour through bioinformatics. Therefore, it is predicted that ZNF146 gene affects the proliferation of muscle cells, and then affects the growth and development of cattle. Furthermore, CNV genotyping of ZNF146 gene was three types (deletion type, normal type and duplication type) by Real-time fluorescent quantitative PCR (qPCR). The association analysis results showed that ZNF146-CNV was significantly correlated with rump length of Qinchuan cattle, hucklebone width of Jiaxian red cattle and heart girth of Yunling cattle. From the above results, ZNF146-CNV had a significant effect on growth traits, which provided an important candidate molecular marker for growth and development of Chinese cattle.
Budgets of turbulent kinetic energy (TKE) and turbulent potential energy (TPE) at different scales $\ell$ in sheared, stably stratified turbulence are analysed using a filtering approach. Competing effects in the flow are considered, along with the physical mechanisms governing the energy fluxes between scales, and the budgets are used to analyse data from direct numerical simulation at buoyancy Reynolds number $Re_b=O(100)$. The mean TKE exceeds the TPE by an order of magnitude at the large scales, with the difference reducing as $\ell$ is decreased. At larger scales, buoyancy is never observed to be positive, with buoyancy always converting TKE to TPE. As $\ell$ is decreased, the probability of locally convecting regions increases, though it remains small at scales down to the Ozmidov scale. The TKE and TPE fluxes between scales are both downscale on average, and their instantaneous values are correlated positively, but not strongly so, and this occurs due to the different physical mechanisms that govern these fluxes. Moreover, the contributions to these fluxes arising from the sub-grid fields are shown to be significant, in addition to the filtered scale contributions associated with the processes of strain self-amplification, vortex stretching and density gradient amplification. Probability density functions (PDFs) of the $Q,R$ invariants of the filtered velocity gradient are considered and show that as $\ell$ increases, the sheared-drop shape of the PDF becomes less pronounced and the PDF becomes more symmetric about $R=0$.