Adhesive strength between V-4Cr-4Ti type alloys and an yttrium oxide layer formed by a plasma spray technique was evaluated by a laser shock spallation method, which uses a pulse laser to generate a shock wave to create tensile stress inside the specimen. There was no significant dependence of the adhesive strength on the alloying elements examined, such as yttrium, silicon and aluminum. Detailed observation of the exfoliation behavior was carried out to identify the weakest interface of the coating layer. Several modes of exfoliation behavior were categorized after cross-sectional observation. There was some uncertainty of the adhesive strength of the layer evaluated by the laser shock method, due to the thickness of the coating layer. The typical adhesive strength between the alloy and yttrium oxide layer was evaluated to be approximately 400 MPa.