To send content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about sending content to .
To send content items to your Kindle, first ensure firstname.lastname@example.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about sending to your Kindle.
Note you can select to send to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
This chapter explores a critical aspect of fetal programming; namely the determinants of uterine blood flow and their role in fetoplacental development. Uterine artery (UA) blood flow can be measured directly in experimental animals but not in humans because of ethical concerns or limitations imposed by the effects of anaesthesia. Pregnancy increases UA diameter at high altitude in all groups, but within a given study the rise in Europeans is less than that seen in Europeans at low altitude or in Andeans at high altitude. Central to the hypothesis is that the Andean women's high UA blood flow during pregnancy helps maintain normal fetal growth. High altitude regions continue to provide an instructive natural laboratory for understanding fetoplacental development. Future studies are required to determine the factors responsible for raising UA blood flow during pregnancy and for explaining the UA blood flow differences between native and newcomer groups.