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We calculated the attributable cost of several healthcare-associated infections in a community hospital network: central-line–associated bloodstream infections (CLABSIs), catheter-associated urinary tract infections (CAUTIs), hospital-onset Clostridioides difficile infections (CDI-HOs) (43 hospitals); surgical site infections (SSIs) (40 hospitals). From 2016 to 2022, the total cost of CLABSIs, CAUTIs, CDI-HOs, and SSIs was $420,012,025.
Initial assessments of coronavirus disease 2019 (COVID-19) preparedness revealed resource shortages and variations in infection prevention policies across US hospitals. Our follow-up survey revealed improvement in resource availability, increase in testing capacity, and uniformity in infection prevention policies. Most importantly, the survey highlighted an increase in staffing shortages and use of travel nursing.
We performed a cross-sectional survey of infection preventionists in 60 US community hospitals between April 22 and May 8, 2020. Several differences in hospital preparedness for SARS-CoV-2 emerged with respect to personal protective equipment conservation strategies, protocols related to testing, universal masking, and restarting elective procedures.
Recent advances in recombinant DNA technology have created the potential for engineering of protein molecules to specific uses beyond those normally considered for biomaterials. This research project has demonstrated the feasibility of producing polypeptides useful for narrow band filters and nonlinear optical applications.
Synthetic genes, ranging in size from 36 to 576 base pairs, have been constructed from oligonucleotides using a restriction doubling technique. The synthetic genes have been inserted into a Protein A fusion expression system. Fused polypeptides from induced cells have been purified by affinity chromatography (IGG), and analyzed by polyacrylamide gel electrophoresis.
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