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In two freestanding volumes, Textbook of Neural Repair and Rehabilitation provides comprehensive coverage of the science and practice of neurological rehabilitation. Revised throughout, bringing the book fully up to date, this volume, Medical Neurorehabilitation, can stand alone as a clinical handbook for neurorehabilitation. It covers the practical applications of the basic science principles presented in Volume 1, provides authoritative guidelines on the management of disabling symptoms, and describes comprehensive rehabilitation approaches for the major categories of disabling neurological disorders. New chapters have been added covering genetics in neurorehabilitation, the rehabilitation team and the economics of neurological rehabilitation, and brain stimulation, along with numerous others. Emphasizing the integration of basic and clinical knowledge, this book and its companion are edited and written by leading international authorities. Together they are an essential resource for neuroscientists and provide a foundation of the work of clinical neurorehabilitation professionals.
Plasticity after injury to the CNS
Agnes Floel, Human Coritical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA,
Leonardo G. Cohen, Human Coritical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
The primary vehicle for acquiring knowledge on plasticity in the human central nervous system (CNS) has been animal research. Understanding of mechanisms, development of strategies to purposefully modulate these mechanisms, and translation into rational strategies to promote recovery of function are the goals of modern neurorehabilitation. Training leads to specific changes in brain organization in the motor, somatosensory, auditory, and visual domain. Acute and chronic alterations in neurotransmitter regulation after injury affect plasticity, and may thus provide a basis for new pharmacologic targets for stroke recovery. One of the strategies proposed to enhance functional recovery and sensory substitution is to use mechanical devices interfaced with human sensory afferents or interacting with the CNS. Intravenous human umbilical cored blood cells (HUCB) infusion may have a beneficial effect on recovery processes. Growth factors seem to exert their effects by local processes including autocrine, paracrine, and juxtacrine stimulation.