Vice-presidents in Latin America have often been at the centre of political turbulence. To prevent conflicts within the executive, most Latin American countries have therefore put in place formulae to elect presidents and vice-presidents on a joint electoral ticket. Still, it is common for presidential candidates to pick running mates from other parties in order to construct alliances and appeal to a broader set of voters. But the presence of such ‘external’ vice-presidents seems to increase the risk of presidential interruption in general and impeachment processes in particular. Accordingly, we argue that the frequently overlooked institution of the vice-president deserves attention as a possible intervening variable that can contribute to the explanation for government crises and their outcomes in Latin America.