This paper reports the results of a high-risk study of children
under age 18 of parents who
served as probands in a family study of comorbidity of substance abuse
and anxiety
disorders. There was a strong degree of specificity of familial aggregation
of both the anxiety
disorders and substance disorders. Rates of conduct disorder and depression
were elevated
among offspring of all affected parents. Inclusion of co-parent disorders
in the evaluation of
familial transmission in the present study strengthened the findings regarding
the specificity
of transmission of the anxiety disorders and the links between both parental
substance abuse
and antisocial personality with child conduct disorder.