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Drawing upon research on the visual complexity effect and Dual Coding Theory, this research examined the influence of character properties and the role of individual learner differences in Chinese character acquisition. The participants included 248 Chinese-speaking children in grades 1 through 3 in Taiwan. The study extended the scope of previous research by concurrently examining two types of cognitive processing: activation of verbal codes with nonverbal codes (activation of word form) and activation of nonverbal codes with verbal codes (activation of meaning). Results revealed the asymmetry in the two types of cognitive processing. Regarding the influence of character properties, while characters with less visual complexity and with radical presence are generally more acquirable, the interaction between these two properties was only present in the activation of meaning but not the activation of word form. Individual differences contributing to character acquisition did not mirror each other in the two directions of cognitive processing either. The contribution of radical awareness and visual skills remained the same across grade levels in the activation of meaning but varied with grades and the properties of the characters in the activation of word form. The methodological and theoretical contributions of the study were discussed.
The development of Maritime Autonomous Surface Ship (MASS) is progressing rapidly within the maritime industry. Degree Two of MASS (MASS-DoA2), balancing human oversight and autonomous efficiency, will likely gain regulatory approval and industry acceptance. MASS-DoA2 possesses different control modes to adapt to various scenarios. However, the control-switching mechanisms among operators at shore control centres, autonomous navigation systems and number of seafarers onboard remain ambiguous, which poses a new risk that may significantly influence navigation safety. This study focuses on MASS-DoA2 and carries out a systematic review of autonomous ship guidelines. A questionnaire was designed based on the review findings, and a survey was carried out among captains and researchers in related fields. The review identified 11 control-switching scenarios with suggested takeover agents and the switching process and outlined the priority relationship between various takeover agents. Finally, a control-switching framework for MASS – DoA2 is proposed. It can serve as a theoretical framework for research on MASS's dynamic degree of autonomy and provide a reference for maritime regulatory authorities in establishing MASS – DoA2 control-switching mechanisms.
We study scaled topological entropy, scaled measure entropy, and scaled local entropy in the context of amenable group actions. In particular, a variational principle is established.
To speed up the construction of grassroots medical and health teams in China, free training of rural order-oriented medical students was launched in June 2010. Based on the theory of policy tools, a quantitative analysis of policy texts at the national level was conducted to explore the use of policy tools and to put forward corresponding suggestions for adjustments.
Methods
From January to February 2023, the research team searched the Peking University Treasure Database and the official websites of the State Council, the National Health Commission, the Ministry of Education, and other ministries for national policy documents related to free training of order-oriented medical students published from June 2010 to May 2023. A policy tool and policy target analysis framework were used to quantitatively analyze the policy documents.
Results
A total of 16 policy documents were included and 213 policy provisions were extracted. From the perspective of policy tools, the proportion of policy provisions using imperative policy tools was the highest (63.4%), followed by advisory policy tools (18.8%). and reward-based policy tools (13.6%). Functional expansion tools (2.8%) and authoritative restructuring tools (1.4%) accounted for a relatively low proportion. The institutional education stage is the main policy target, with provisions accounting for 75 percent (162 articles), followed by the continuing education stage (17.6%; 38 articles), and the postgraduate education stage (7.4%; 16 articles).
Conclusions
The distribution of policy tools for the free training policy of rural order-oriented medical students in China needs to be balanced, and the internal combination of the same policy tools needs to be optimized. The policy targets were mainly concentrated in the education stage of universities.
The exploration of molecular characteristics has emerged as a prominent trend to advance precision medicine. The utilization of genetic testing to guide therapy is integral to precision medicine. This study aims to investigate the potential patient populations for the reimbursement of next-generation sequencing (NGS) and assess the budget impact from the perspective of Taiwan’s single insurer, the National Health Insurance Administration.
Methods
To comprehend the scope for medicines with companion diagnostics (CDx) involved, we analyze the U.S. Food and Drug Administration-approved/cleared diagnostic tests, conduct a literature review to identify medicines approved by the European Medicines Agency that require a CDx, and identify the medicines with CDx involved covered by the National Health Insurance (NHI) in Taiwan. Subsequently, we explore the potential reimbursement indications for NGS testing and conduct a budget impact analysis to evaluate the expected financial impact for the NHI over a five-year period. Furthermore, sensitivity analyses are conducted to deal with uncertainty.
Results
We have compiled 13 cancer types for which NGS can serve as a companion diagnostic. These encompass non-small-cell lung cancer, colorectal cancer, breast cancer, ovarian cancer, biliary tract cancer, acute myeloid leukemia, acute lymphoblastic leukemia, melanoma, cholangiocarcinoma, prostate cancer, pancreatic cancer, gastrointestinal stromal tumor, and thyroid cancer/medullary thyroid cancer. The implementation of NGS reimbursement in NHI will benefit 25,000 to 30,000 patients undergoing targeted therapies. The projected incremental budget impact ranges from TWD570 million to TWD650 million (USD19 million to USD22 million) over five years.
Conclusions
This study focuses on evaluating the financial impact of incorporating NGS testing into NHI reimbursement for relevant cancer drug indications. The findings can serve as references for the planning of reimbursement policies. However, with the advancement of precision medicine, it is foreseeable that there will be a broader range of applications for NGS, and its cost will gradually decrease.
With the aging population, chronic diseases have become a serious threat to public health in China. Adhering to the doctor’s advice is an effective strategy for controlling chronic diseases, and the preferences of patients with chronic disease has an important impact on compliance with medication. However, there is insufficient research exploring this aspect.
Methods
In this study patients with chronic disease were selected by stratified random sampling to participate in a survey carried out in three cities of a province in eastern China. The discrete choice experiment used a questionnaire of D-efficiency experimental design to measure the medication choices of patients with chronic disease. The main attributes included drug price, onset of action, adverse reactions, traditional Chinese or Western medicine, domestic drug, and reimbursed by medical insurance. The data were analyzed using a mixed logit model.
Results
A total of 1,062 valid questionnaires were received. The 1,045 questionnaires that passed the consistency test covered three prefecture-level cities, nine counties, and 216 villages. All drug attributes were statistically significant for selection preferences. The preference of patients in rural areas with chronic disease was “quick onset of action” (β=2.491), “Western medicine” (β=0. 826), “medical insurance” (β=0.556), “domestic drugs” (β=0.286), and “very few adverse reactions” (β=0.170). “Drug price” also had an impact on medication preferences among patients in rural areas with chronic disease (β=−0.013).
Conclusions
Onset of action is the attribute of medications that is of most concern for patients in rural areas with chronic disease. Subgroup analysis showed that these patients were predominantly female, had a primary school education or lower, were younger than 69 years, were unemployed, and had an annual income between CNY10,000 (USD1,396.78) and CNY50,000 (USD6,983.92). They were willing to pay more for drugs with a quick onset of action, Western medicines, and drugs with reimbursed by medical insurance.
While environmental concerns are increasingly driving firms’ strategic decisions, insights into why firms make heterogeneous environmental investments are limited. Taking an institutional view, we explore the effect of institutional complexity resulting from multiple but incongruent institutional logics within an organization on firms’ environmental investments. Using China's mixed-ownership reform as a research context, we identify a unique condition in which institutional complexity arises as the privatization process results in two coexisting but incongruent institutional logics – namely, state and financial logic. We further propose that privatization plays both enabling and constraining roles in state-owned enterprises’ (SOEs’) strategic decisions about environmental investments, depending on the relative dominance of each institutional logic, resulting in an inverted U-shaped relationship between privatization and environmental investments. Moreover, we examine the moderating effects of CEO background characteristics and firms’ external environmental context to uncover how these factors influence the relative dominance of state or financial logic in privatized SOEs, thereby reshaping SOEs’ environmental investments. Analyses of multisource panel data from Chinese listed SOEs from 2013 to 2020 support our theoretical propositions. The findings contribute to the literature on how institutional factors affect firm environmental practices and provide new insights to better understand the influence of institutional complexity on firm strategic actions.
External seeded free-electron lasers (FELs) have exhibited substantial progress in diverse applications over the last decade. However, the frequency up-conversion efficiency in single-stage seeded FELs, particularly in high-gain harmonic generation (HGHG), remains constrained to a modest level. This limitation restricts its capability to conduct experiments within the ‘water window’. This paper presents a novel method for generating coherent X-ray FEL pulses in the water window region based on the HGHG scheme with multi-stage harmonic cascade. Without any additional modifications to the HGHG configuration, simulation results demonstrate the generation of intense 3 nm coherent FEL radiation using an external ultraviolet seed laser. This indicates an increase of the harmonic conversion number to approximately 90. A preliminary experiment is performed to evaluate the feasibility of this method. The proposed approach could potentially serve as an efficient method to broaden the wavelength coverage accessible to both existing and planned seeded X-ray FEL facilities.
This paper introduces a novel fiber-based picosecond burst-mode laser system capable of operating at high power and high repetition rates. A pulse-circulating fiber ring was developed as a burst generator, achieving an intra-burst repetition rate of 469 MHz without the need for a high-repetition-rate seed source. This design also allows for flexible adjustment of the number of sub-pulses, burst repetition rate and burst shape. In addition, a master oscillator power amplifier was employed to analyze the amplification characteristics of bursts. The system demonstrated a maximum average power of 606 W, with a measured sub-pulse duration of 62 ps and the highest sub-pulse peak power of 980 kW. To the best of our knowledge, this marks the highest average power obtained in burst-mode ultrafast lasers. Such a laser system holds potential for applications in precision manufacturing, high-speed imaging, high-precision ranging and other diverse domains.
Missing data occur in many real world studies. Knowing the type of missing mechanisms is important for adopting appropriate statistical analysis procedure. Many statistical methods assume missing completely at random (MCAR) due to its simplicity. Therefore, it is necessary to test whether this assumption is satisfied before applying those procedures. In the literature, most of the procedures for testing MCAR were developed under normality assumption which is sometimes difficult to justify in practice. In this paper, we propose a nonparametric test of MCAR for incomplete multivariate data which does not require distributional assumptions. The proposed test is carried out by comparing the distributions of the observed data across different missing-pattern groups. We prove that the proposed test is consistent against any distributional differences in the observed data. Simulation shows that the proposed procedure has the Type I error well controlled at the nominal level for testing MCAR and also has good power against a variety of non-MCAR alternatives.
Although dietary factors have been examined as potential risk factors for liver cancer, the evidence is still inconclusive. Using a diet-wide association analysis, our research evaluated the associations of 126 foods and nutrients on the risk of liver cancer in a Chinese population. We obtained the diet consumption of 72,680 women in the Shanghai Women’s Health Study using baseline dietary questionnaires. The association between each food and nutrient and liver cancer risk was quantified by Cox regression model. A false discovery rate of 0.05 was used to determine the foods and nutrients which need to be verified. Totally 256 incident liver cancer cases were identified in 1,267,391 person-years during the follow-up duration. At the statistical significance level (P ≤ 0.05), higher intakes of cooked wheaten foods, pear, grape and copper were inversely associated with liver cancer risk, while spinach, leafy vegetables, eggplant and carrots showed the positive associations. After considering multiple comparisons, no dietary variable was associated with liver cancer risk. Similar findings were seen in the stratification, secondary and sensitivity analyses. Our findings observed no significant association between dietary factors and liver cancer risk after considering multiple comparisons in Chinese women. More evidence is needed to explore the associations between diet and female liver cancer occurrence.
Large-aperture gratings have significant applications in inertial confinement fusion, immersion lithography manufacturing and astronomical observation. Currently, it is challenging and expensive to manufacture sizable monolithic gratings. Therefore, tiled multiple small-aperture gratings are preferred. In this study, the impact of seam phase discontinuity on the modulation of the laser beam field was explored based on the measurement results of the Shenguang-II laser large-aperture multi-exposure-tiled grating. An innovative method for accurately calculating the phase jump of multi-exposure-tiled grating seams was proposed. An intensive electromagnetic field analysis was performed by applying rigorous coupled-wave analysis to a reasonably constructed micrometer-level periodic grating seam structure, and the phase jump appearing in millimeter-scale seams of large-aperture tiled gratings was obtained accurately.
Robot pick-and-place for unknown objects is still a very challenging research topic. This paper proposes a multi-modal learning method for robot one-shot imitation of pick-and-place tasks. This method aims to enhance the generality of industrial robots while reducing the amount of data and training costs the one-shot imitation method relies on. The method first categorizes human demonstration videos into different tasks, and these tasks are classified into six types to symbolize as many types of pick-and-place tasks as possible. Second, the method generates multi-modal prompts and finally predicts the action of the robot and completes the symbolic pick-and-place task in industrial production. A carefully curated dataset is created to complement the method. The dataset consists of human demonstration videos and instance images focused on real-world scenes and industrial tasks, which fosters adaptable and efficient learning. Experimental results demonstrate favorable success rates and loss results both in simulation environments and real-world experiments, confirming its effectiveness and practicality.
In this work, the Riemann–Hilbert (RH) problem is employed to study the multiple high-order pole solutions of the cubic Camassa–Holm (cCH) equation with the term characterizing the effect of linear dispersion under zero boundary conditions and nonzero boundary conditions. Under the reflectionless situation, we generalize the residue theorem and obtain the multiple high-order pole solutions of cCH equation by solving an algebraic system. During the process of establishing the solution of RH problem, to simplify the calculations involving the implicitly expressed of variables (x, t) in the solution, we introduce a new scale (y, t) to ensure the solution of RH problem is explicitly expressed with respect to it. Finally, the exact solutions are obtained for cases involving one high-order pole and N high-order poles.
Let $L=-\Delta +V$ be a Schrödinger operator in ${\mathbb R}^n$ with $n\geq 3$, where $\Delta $ is the Laplace operator denoted by $\Delta =\sum ^{n}_{i=1}({\partial ^{2}}/{\partial x_{i}^{2}})$ and the nonnegative potential V belongs to the reverse Hölder class $(RH)_{q}$ with $q>n/2$. For $\alpha \in (0,1)$, we define the operator
where $\{e^{-tL^\alpha } \}_{t>0}$ is the fractional heat semigroup of the operator L, $\{v_j\}_{j\in \mathbb Z}$ is a bounded real sequence and $\{a_j\}_{j\in \mathbb Z}$ is an increasing real sequence.
We investigate the boundedness of the operator $T_N^{L^{\alpha }}$ and the related maximal operator $T^*_{L^{\alpha }}f(x):=\sup _N \vert T_N^{L^{\alpha }} f(x)\vert $ on the spaces $L^{p}(\mathbb {R}^{n})$ and $BMO_{L}(\mathbb {R}^{n})$, respectively. As extensions of $L^{p}(\mathbb {R}^{n})$, the boundedness of the operators $T_N^{L^{\alpha }}$ and $T^*_{L^{\alpha }}$ on the Morrey space $L^{\rho ,\theta }_{p,\kappa }(\mathbb {R}^{n})$ and the weak Morrey space $WL^{\rho ,\theta }_{1,\kappa }(\mathbb {R}^{n})$ has also been proved.
The maser instability associated with the loss-cone distribution has been widely invoked to explain the radio bursts observed in the astrophysical plasma environment, such as aurora and corona. In the laboratory plasma of a tokamak, events reminiscent of these radio bursts have also been frequently observed as an electron cyclotron emission (ECE) burst in the microwave range ($\mathrm{\sim }2{f_{\textrm{ce}}}$ near the last closed flux surface) during transient magnetohydrodynamic events. These bursts have a short duration of ~10 μs and display a radiation spectrum corresponding to a radiation temperature ${T_{e,\textrm{rad}}}$ of over $30\ \textrm{keV}$ while the edge thermal electron temperature ${T_e}$ is only in the range of $1\ \textrm{keV}$. Suprathermal electrons can be generated through magnetic reconnection, and a loss-cone distribution can be generated through open stochastic field lines in the magnetic mirror of the near-edge region of a tokamak plasma. Radiation modelling shows that a sharp distribution gradient $\partial f/\partial {v_ \bot } > 0$ at the loss-cone boundary can cause a negative absorption of ECE radiation through the maser instability. The negative absorption then amplifies the radiation so that the microwave intensity is significantly stronger than the thermal value. The significant ${T_{e,\textrm{rad}}}$ from the simulations suggests the potential role of the loss-cone maser instability in generating the ECE burst in a tokamak.
Isolated multi-MeV $\gamma$-rays with attosecond duration, high collimation and beam angular momentum (BAM) may find many interesting applications in nuclear physics, astrophysics, etc. Here, we propose a scheme to generate such $\gamma$-rays via nonlinear Thomson scattering of a rotating relativistic electron sheet driven by a few-cycle twisted laser pulse interacting with a micro-droplet target. Our model clarifies the laser intensity threshold and carrier-envelope phase effect on the generation of the isolated electron sheet. Three-dimensional numerical simulations demonstrate the $\gamma$-ray emission with 320 attoseconds duration and peak brilliance of $9.3\times 10^{24}$ photons s${}^{-1}$ mrad${}^{-2}$ mm${}^{-2}$ per 0.1$\%$ bandwidth at 4.3 MeV. The $\gamma$-ray beam carries a large BAM of $2.8 \times 10^{16}\mathrm{\hslash}$, which arises from the efficient BAM transfer from the rotating electron sheet, subsequently leading to a unique angular distribution. This work should promote the experimental investigation of nonlinear Thomson scattering of rotating electron sheets in large laser facilities.
This study examined the sour grapes/sweet lemons rationalization through 2 conditions: ‘attainable’ (sweet lemons) and ‘unattainable’ (sour grapes), reflecting China’s 2019-nCoV vaccination strategy. The aim was to find ways to change people’s beliefs and preferences regarding vaccines by easing their safety concerns and encouraging more willingness to get vaccinated. An online survey was conducted from January 22 to 27, 2021, with 3,123 residents across 30 provinces and municipalities in the Chinese mainland. The direction of belief and preference changed in line with the sour grapes/sweet lemons rationalization. Using hypothetical and real contrasts, we compared those for whom the vaccine was relatively unattainable (‘sour grapes’ condition) with those who could get the vaccine easily (‘sweet lemons’). Whether the vaccine was attainable was determined in the early stage of the vaccine roll-out by membership in a select group of workers that was supposed to be vaccinated to the greatest extent possible, or, by being in the second stage when the vaccine was available to all. The attainable conditions demonstrated higher evaluation in vaccine safety, higher willingness to be vaccinated, and lower willingness to wait and see. Hence, we propose that the manipulation of vaccine attainability, which formed the basis of the application of sour grapes/sweet lemons rationalization, can be utilized as a means to manipulate the choice architecture to nudge individuals to ease vaccine safety concerns, reducing wait-and-see tendencies, and enhancing vaccination willingness. This approach can expedite universal vaccination and its associated benefits in future scenarios resembling the 2019-nCoV vaccine rollout.