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S39.03 - Candidate genes and brain cortical morphology in schizophrenia
I. Agartz, K. Varnäs, G. Lawyer, E.G. Jönsson, B. Kulle, R. Nesvåg, H. Hall, L. Terenius, P. Saetre
Journal:

European Psychiatry / Volume 23 / Issue S2 / April 2008

Published online by Cambridge University Press:

16 April 2020, p. S58
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Aim:
To investigate associations between schizophrenia candidate gene polymorphisms and regional cortical thickness and volume in patients with schizophrenia and healthy control subjects.
Methods:
Genotyping was performed using PCR and pyrosequencing techniques. Cortical morphology was analyzed by processing magnetic resonance brain images with the FreeSurfer software package. General linear model analysis was used to study associations between gene variants and cortical thickness in patients and controls, respectively. Regional cortical volumes were defined from automatic cortical parcellations. Our first studies from 96 patients with schizophrenia and 104 healthy control subjects demonstrate that polymorphisms in the brain derived neurotrophic factor (BDNF) gene may be associated with variation in frontal lobe morphology. Associations seem to be stronger in patients with schizophrenia than in healthy controls.

Genes and alcohol
U. Ösby, J. Liljenberg, I. Kockum, A. Gunnar, L. Terenius
Journal:

European Psychiatry / Volume 25 / Issue 5 / June 2010

Published online by Cambridge University Press:

16 April 2020, pp. 281-283
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The negative effects of excessive alcohol use include dependence, psychiatric co-morbidity and increased risk for suicide. A dominating risk factor is heritage. A large number of studies have addressed the genetic basis, either “candidate genes” in the brain reward system, or searched for unknown genes in family studies by linkage analysis. It is clear that no single gene polymorphism is of use in preventive medicine. A consistent finding, however, is that polymorphism in the alcohol dehydrogenase cluster and other metabolic pathways are of some relevance on a population basis, suggesting a link between alcohol toxicity in general and dependence. An emerging concern is potential gender differences as women, who are generally more sensitive, acquire male drinking habits.

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