Our current knowledge of star formation and accretion luminosity at high redshift (z > 3–4), as well as the possible connections between them, relies mostly on observations in the rest-frame ultraviolet, which are strongly affected by dust obscuration. Due to the lack of sensitivity of past and current infrared instrumentation, so far it has not been possible to get a glimpse into the early phases of the dust-obscured Universe. Among the next generation of infrared observatories, SPICA, observing in the 12–350 µm range, will be the only facility that can enable us to trace the evolution of the obscured star-formation rate and black-hole accretion rate densities over cosmic time, from the peak of their activity back to the reionisation epoch (i.e., 3 < z ≲ 6–7), where its predecessors had severe limitations. Here, we discuss the potential of photometric surveys performed with the SPICA mid-infrared instrument, enabled by the very low level of impact of dust obscuration in a band centred at 34 µm. These unique unbiased photometric surveys that SPICA will perform will fully characterise the evolution of AGNs and star-forming galaxies after reionisation.

Adaptive Optics (AO) will be essential for accomplishing many, if not most, of the science objectives currently planned for Extremely Large Telescopes including GMT, OWL, and TMT. AO will be needed to support a range of instrumentation, including near infrared (IR) imagers and spectrometers, mid IR imagers and spectrometers, “planet finding” instrumentation and wide-field optical spectrographs. Multiple advanced AO systems, utilizing the full range of concepts currently under development, will need to be combined into an integrated architecture to meet a broad range of requirements for field-of-view, spatial resolution and spectral bandpass.

In this paper, we describe several of the possible options for these systems and outline the range of issues, trade studies and component development activities which must be addressed. Some of these challenges include very high-order, large-stroke wavefront correction, tip-tilt sensing with faint natural guide stars to maximize sky coverage, laser guide star wavefront sensing on a very large aperture and achieving extremely high contrast ratios for the detection of extra-solar planet and other faint companions of nearby bright stars.

Background: Volumetric magnetic resonance imaging (MRI) has been extensively studied in the last decade as a method to help with the clinical diagnosis of Alzheimer's disease (AD). In recent years, researchers have also started investigating if that technique would be useful to identify individuals with mild cognitive impairment (MCI), differentiating them from AD patients and from normal elderly controls. This research project was planned to assess the accuracy of volumetric MRI to differentiate those groups of individuals. Method: The investigation involved 39 patients with diagnosis of mild to moderate dementia in AD, according to the criteria of the NINCDS-ADRDA, DSM-III-R, and ICD-10; 21 subjects with complaints of cognitive decline without other psychiatric disorders (MCI); and 20 normal elderly controls. All the subjects were submitted to a standard protocol, including volumetric MRI evaluations. Results: The results indicated that all regions of interest measured (amygdala, hippocampus, and parahippocampal gyrus) were significantly different (p < .005) in AD patients compared to MCI subjects and controls. The left volumetric measures (amygdala, hippocampus, and parahippocampal gyrus) were also significantly different between the MCI subjects and controls (p < .05). The discriminant function analysis correctly classified 88.14% of the AD patients and controls, 81.67% of AD patients and MCI subjects, and 80.49% of the MCI subjects and controls. Conclusions: The results suggest that measures of medial temporal lobe regions are useful to identify mild to moderate AD patients and MCI subjects, separating them from normal elderly individuals.

Optical properties of size restricted Cu2O obtained through aqueous and non aqueous preparations are compared with those of commercially available bulk crystals. One method of synthesis involved using polyvinyl alcohol as a restraining agent in an aqueous preparation to produce nanocrystals having diameters with a mean of 11 nm and a standard deviation of 6 nm. Low-temperature spectroscopie studies indicate size restriction effects are manifest by a decrease in exciton luminescence and a 3.0 to 9.0 meV blue shift in 0,0 transition. No noticeable changes in the dynamics were observed for the nanocrystals, indicating no alteration or relaxation of the selection rules for the direct forbidden transition.

The Authors study the distribution of the various classes of Arneth's formula in 39 healthy MZ pairs, 38 healthy DZ pairs, 10 MZ pairs with non-concordant disease.

They conclude that borh genetic and pathologic factors are relevant in the determination of the formula, and they will try to establish the importance of each factor through a further study on a group of DZ pairs with non-concordant disease.