Aorto-right-atrial fistula is an uncommon condition with an unclear pathogenesis. We present the case of a 3-year-old girl with a giant omphalocele repaired days after birth and incidentally discovered with a celiacomesenteric trunk-to-right atrium fistula. Three-dimensional reconstruction CT unveiled its anatomical pattern, and the fistula was successfully closed using a Amplatzer vascular plug II percutaneously.

The mitochondrial genome provides important information for phylogenetic analysis and an understanding of evolutionary origin. In this study, the mitochondrial genomes of Ilisha elongata and Setipinna tenuifilis were sequenced, which are typical circular vertebrate mitochondrial genomes composed of 16,770 and 16,805 bp, respectively. The mitogenomes of I. elongata and S. tenuifilis include 13 protein-coding genes (PCGs), 22 transfer RNA (tRNA), two ribosomal RNA (rRNA) genes and one control region (CR). Both two species' genome compositions were highly A + T biased and exhibited positive AT-skews and negative GC-skews. The genetic distance and Ka/Ks ratio analyses indicated that 13 PCGs were affected by purifying selection and the selection pressures were different from certain deep-sea fishes, which were most likely due to the difference in their living environment. Results of phylogenetic analysis support close relationships among Chirocentridae, Denticipitidae, Clupeidae, Engraulidae and Pristigasteridae based on the nucleotide and amino acid sequences of 13 PCGs. Within Clupeoidei, I. elongata and S. tenuifilis were most closely related to the family Pristigasteridae and Engraulidae, respectively. These results will help to better understand the evolutionary position of Clupeiformes and provide a reference for further phylogenetic research on Clupeiformes species.

In the present study, turbulent particle-laden boundary layer combustion over a flat plate is investigated using direct numerical simulation (DNS). A two-way coupled Eulerian–Lagrangian point particle method is used for the solid phase. The effects of particle Stokes numbers, mass loadings and chemical reactions on the interactions between particles and boundary layer turbulence in the near-wall region are explored. It was found that particle heat transfer is dominant over wall heat transfer in the reacting case with heavy particles and large mass loadings, resulting in a lower fluid temperature. Particle accumulation due to the turbophoresis effect in the near-wall region is observed, which is more prominent in the cases with a large Stokes number. The turbophoresis effect is examined via the magnitude of streamwise vorticity $\varOmega _x$. It is shown that $\varOmega _x$ is attenuated by heavy particles, and the attenuation increases with increasing mass loadings. Therefore, particle wall–accumulation is less prominent in the cases with large mass loadings. Compared with the non-reacting cases, the distribution of particles is more inhomogeneous for the reacting cases, where the particles move faster due to intense reactions with increasing wall-normal distance. Finally, the flow topologies and the Reynolds stress anisotropy are examined to understand turbulence modulation by combustion and particles. It was suggested that light particles augment the vortex-dominant topologies, whereas heavy particles have an opposite effect. The anisotropy mapping of the Reynolds stress shows that the flows become more one-dimensional in the near-wall region for the cases with combustion and/or large mass loadings.

The Lochkovian (Lower Devonian) conodont biostratigraphy in China is poorly known, and conodont-based subdivision schemes for the Lochkovian in peri-Gondwana (the Spanish Central Pyrenees, the Prague Synform, Sardinia, and the Carnic Alps) have not been tested in China. Therefore, we studied conodonts from the lower part (Bed 9 to Bed 13) of the Shanjiang Formation at the Alengchu section of Lijiang, western Yunnan to test the application of established subdivision schemes. The conodont fauna is assignable to 12 taxa belonging to eight genera (Ancyrodelloides, Flajsella, Lanea, Wurmiella, Zieglerodina, Caudicriodus, Pelekysgnathus, and Pseudooneotodus), and enables recognition of two chronostratigraphical intervals from the lower part of the Shanjiang Formation. The interval ranging from the uppermost part of Bed 9 to the upper part of Bed 10 belongs to the lower Lochkovian; whereas an interval covering the uppermost part of Bed 11 to the upper part of Bed 13 is correlated with the upper half of the middle Lochkovian. The Silurian-Devonian boundary is probably located within Bed 9, in the basal part of the Shanjiang Formation. However, the scarcity of specimens precludes definitive identification of bases of the lower, middle, and upper Lochkovian as well as other conodont zones recognized in peri-Gondwana.

Existing studies have examined the demand elasticities for organic products only in select categories, and their results for consumers' sensitivity to price changes are inconsistent. Evidence regarding the effects of price promotions on the demand for organic foods vs non-organic foods is scarce. This study aims to (1) examine the own-price elasticities of organic foods vs non-organic counterparts both with and without a promotion in a variety of product categories, and (2) investigate how the distinctive promotion effects between organic and non-organic counterparts depend on food category features. Using purchase data for 36 food categories from the 2015 Nielsen Consumer Panel, we find differential own-price elasticities for organic and non-organic foods, regardless of whether the product is purchased with a promotion. When the products are purchased with a promotion, we find stronger price promotion effects of organic virtues than non-organic virtues and weaker price promotion effects of organic vices than conventional vices. Price promotions of organic foods are more likely to induce health-conscious consumers to switch from conventional purchases to organic purchases in virtues.

This study aimed to evaluate the performance of Cobas human papillomavirus (HPV) test in cervical cancer screening. A total of 3442 women aged ⩾20 years used Cobas HPV and hybrid capture 2 (HC2) tests were included in this study. Women with any positive result were examined by liquid-based cytology (LBC) test. Then subjects with abnormal LBC or positive Cobas HPV16/18 were further checked by colposcopy to observe the visible lesions to perform the pathological examination. Of these 3442 women, 328 cases were Cobas HPV positive, and the positive rate was 9.53% (95% confidence interval (CI) 8.50–10.53). The positive rate of HPV16, HPV18, and other 12 types of high-risk HPV were 1.54% (95% CI 1.12–1.95), 0.55% (95% CI 0.30–0.80), and 7.44% (95% CI 6.56–8.32), respectively. The coincidence rate of Cobas HPV test and HC2 test was 90% (95% CI 89.00–91.00; Kappa = 0.526) in the primary screening. Age had a non-linear relationship with Cobas HPV positive rate (χ2 = 4.240, P = 0.040) and HPV16/18 typing positive rate (χ2 = 6.610, P = 0.010). Compared with the LBC test, the Cobas HPV test had higher sensitivity when detecting patients with high cervical intraepithelial neoplasia (CIN2+ and CIN3+).

DNA methylation is one of the most important epigenetic modifications in breast cancer (BC) development, and long-term dietary habits can alter DNA methylation. Cadherin-4 (CDH4, a member of the cadherin family) encodes Ca2+-dependent cell–cell adhesion glycoproteins. We conducted a case–control study (380 newly diagnosed BC and 439 cancer-free controls) to explore the relationship of CDH4 methylation in peripheral blood leukocyte DNA (PBL DNA), as well as its combined and interactive effects with dietary factors on BC risk. A case-only study (335 newly diagnosed BC) was conducted to analyse the association between CDH4 methylation in breast tissue DNA and dietary factors. CDH4 methylation was detected using quantitative methylation-specific PCR. Unconditional logistic regressions were used to analyse the association of CDH4 methylation in PBL DNA and BC risk. Cross-over analysis and unconditional logistic regression were used to calculate the combined and interactive effects between CDH4 methylation in PBL DNA and dietary factors in BC. CDH4 hypermethylation was significantly associated with increased BC risk in PBL DNA (ORadjusted (ORadj) = 2·70, (95 % CI 1·90, 3·83), P < 0·001). CDH4 hypermethylation also showed significant combined effects with the consumption of vegetables (ORadj = 4·33, (95 % CI 2·63, 7·10)), allium vegetables (ORadj = 7·00, (95 % CI 4·17, 11·77)), fish (ORadj = 7·92, (95 % CI 3·79, 16·53)), milk (ORadj = 6·30, (95 % CI 3·41, 11·66)), overnight food (ORadj = 4·63, (95 % CI 2·69, 7·99)), pork (ORadj = 5·59, (95 % CI 2·94, 10·62)) and physical activity (ORadj = 4·72, (95 % CI 2·87, 7·76)). Moreover, consuming milk was significantly related with decreased risk of CDH4 methylation (OR = 0·61, (95 % CI 0·38, 0·99)) in breast tissue. Our findings may provide direct guidance on the dietary intake for specific methylated carriers to decrease their risk for developing BC.

The present paper focuses on the structures and dynamics of flame edges in planar turbulent non-premixed flames bounded with a wall using direct numerical simulation (DNS). The global quenching behaviour was first examined and the flame edges were identified based on the intersections of mixture fraction and OH mass fraction iso-surfaces. For the upper branch of the planar jet flame, it is observed that the structures of flame edges change from tribrachial to monobrachial with increasing scalar dissipation rate. The flame edge speed is negatively correlated with the scalar dissipation rate in regions away from the wall, highlighting the role of turbulent mixing on the flame edge dynamics. During flame–wall interactions, the propagation speed of flame edges is mainly affected by the projection of edge flame normal in the wall-normal direction, i.e. $\boldsymbol {N}_{Z}\boldsymbol {\cdot }\boldsymbol {N}_{wall}$. In particular, the propagation speed increases with increasing $\boldsymbol {N}_{Z}\boldsymbol {\cdot }\boldsymbol {N}_{wall}$ in the near-wall region. The interactions of flame edges and turbulence bounded with a wall are characterized by the alignment between edge flame normal and principal strain rates. The normal of quenching edges has a tendency to align with the most extensive strain rate $\boldsymbol {e}_{1}$ in regions where the heat-release-induced dilatation is dominant over turbulent strain. In contrast, when the heat loss by cold wall effect is large enough to counteract the heat release induced by chemical reactions, turbulent strain is prevalent and the edge flame normal of the quenching edges preferentially aligns with the most compressive strain rate $\boldsymbol {e}_{3}$.

Three-dimensional (3-D) measurements of flame stretch are experimentally challenging. In this paper, two-dimensional (2-D) and 3-D measurements of flame stretch and turbulence–flame interactions were examined using direct numerical simulation (DNS) data of turbulent premixed flames, and models to estimate 3-D statistics of flame stretch-related quantities by correcting 2-D measurements were developed. A variety of DNS cases were simulated, including three freely propagating planar flames without a mean shear and a slot-jet flame with a mean shear. The main findings are summarized as follows. First, the mean shear mainly influences the flame orientations. However, it does not change the flame stretch and turbulence–flame interactions qualitatively. The distributions of out-of-plane angle of all cases are nearly isotropic. Second, models were proposed to approximate the 3-D statistics of flame stretch-related quantities using 2-D measurements, the performance of which was verified by comparing modelled and actual 3-D surface averages and probability density functions of tangential strain rate, curvature and displacement velocity. Third, 2-D measurements of flame stretch capture properly the trends of the 3-D results, with flame surface area being produced in low curvature regions and destroyed in highly curved regions. However, the magnitude of flame stretch was under-estimated in 2-D measurements. Finally, 2-D and 3-D turbulence–flame interactions were examined. The flame normal vector is aligned with the most compressive strain rate in both 2-D and 3-D measurements. Meanwhile, the flame normal vector is misaligned (weakly aligned) with the most extensive strain rate in 3-D (2-D) measurements, highlighting the difference in 2-D and 3-D results of turbulence–flame interactions.

We have proposed and experimentally demonstrated a novel scheme for efficient mid-infrared difference-frequency generation based on passively synchronized fiber lasers. The adoption of coincident seeding pulses in the nonlinear conversion process could substantially lower the pumping threshold for mid-infrared parametric emission. Consequently, a picosecond mid-infrared source at 3.1 μm was prepared with watt-level average power, and a maximum power conversion efficiency of 77% was realized from pump to down-converted light. Additionally, the long-term stability of generated power was manifested with a relative fluctuation as low as 0.17% over one hour. Thanks to the all-optical passive synchronization and all-polarization-maintaining fiber architecture, the implemented laser system was also featured with simplicity, compactness and robustness, which would favor subsequent applications beyond laboratory operation.

Solid solution 0.94Na0.5Bi0.5TiO3–6BaTiO3 (NBT–6BT) is considered to be one kind of lead-free piezoelectric materials with excellent electrical properties due to the existence of morphotropic phase boundary (MPB). However, its relatively lower depolarization temperature is a long-standing bottleneck for the application of NBT-based piezoelectric ceramics. In this work, the influence of thermal quenching on depolarization temperature and electrical properties of rare-earth Ho-doped NBT–6BT lead-free ceramics was investigated. It was shown that the relative high piezoelectric performance, as well as an improvement of depolarization temperature (Td), can be realized by thermal quenching. The results showed that the quenching process induced high concentration of oxygen vacancy, giving rise to the change of octahedra mode and enhanced lattice distortion, which is benefit to the temperature stability of piezoelectric and ferroelectric properties. Furthermore, up-conversion photoluminescence (PL) of Ho-doped NBT–6BT could be effectively tuned by the introduction of oxygen vacancy, suggesting a promising potential in optical–electrical multifunctional devices.

Organic light-emitting diodes (OLEDs) have aroused great attention due to the advantages of high luminescent efficiency, fast response time, wide viewing angle, and the compatibility with the flexible electronics. Nevertheless, the organic luminescent materials are vulnerable to environment moisture/oxygen. Thus, how to protect the OLEDs from the ambient moisture/oxygen erosion is of great importance to ensure the stability and reliability. Thin film encapsulation (TFE) via atomic layer deposition (ALD) has emerged as a potential method to meet the encapsulation requirements of OLEDs due to its unique assets. In this review, the challenges of TFE, including pinholes, crystallization, cracks, and overheated, are introduced first. The ALD-based monolayer, composite structures, and hybrid laminates were developed to improve the barrier property, flexibility, and thermal conductivity. Besides, the ALD reactors and processes for TFE are also reviewed. Finally, the challenges remained and future development in the stabilization of OLEDs via ALD are also discussed.