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This chapter describes the origins, principles and organization of the Cambridge Memory Clinic (CMC). The main objective of CMC was to assess patients complaining of memory impairment and patients whose memory is considered as impaired by others, even when the patient has no awareness of deficit. Clinical neuropsychology is concerned with the evaluation of cognitive function in patients with known or suspected neurological disease. It is often used as a tool for monitoring a change in function, to provide guidelines for rehabilitation and it plays a major role in the differential diagnosis between neurological and psychiatric disorders. The assessment of general intellectual skills gives information regarding the integrity of cortical functioning as a whole and this in itself can be of diagnostic significance. Knowledge of occupational and educational background can give an idea of an individual's optimal or premorbid level of ability.
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