Field and greenhouse experiments were conducted during 2005 and 2006 at Stoneville, MS, to determine control of ragweed parthenium with several preemergence (PRE) and postemergence (POST) herbicides registered for use in corn, cotton, peanut, rice, and soybean. Norflurazon, pendimethalin, clomazone, diuron, fluometuron, pyrithiobac, dimethenamid, flumetsulam, imazaquin, s-metolachlor, metribuzin, chlorimuron, atrazine, simazine, flumioxazin, and quinclorac were applied PRE. Ragweed parthenium control was highest with norflurazon (100%) and clomazone (100%) followed by fluometuron (96%), metribuzin (90%), diuron (87%), flumioxazin (84%), chlorimuron (77%), and quinclorac (67%) at 6 wk after treatment (WAT) under greenhouse conditions. Control of ragweed parthenium was less than 58% with all other herbicides. Ragweed parthenium appears to be highly sensitive to pigment and photosynthetic inhibitors compared to herbicides with other modes of action. Glyphosate, glufosinate, paraquat, bentazon, acifluorfen, chlorimuron, halosulfuron, MSMA, bromoxynil, atrazine, 2,4-D, flumioxazin, trifloxysulfuron, and clomazone were applied POST to field-grown rosette and bolted plants. Glyphosate, glufosinate, chlorimuron, and trifloxysulfuron applied at rosette stage provided greater than 93% control of ragweed parthenium at 3 WAT. Halosulfuron, MSMA, bromoxynil, 2,4-D, and flumioxazin controlled 58 to 90% rosette ragweed parthenium at 3 WAT. Ragweed parthenium control with all other POST herbicides was less than 38%. At bolted stage, glyphosate, glufosinate, and trifloxysulfuron controlled 86 to 95% ragweed parthenium and control was 61 to 70% with chlorimuron, halosulfuron, and 2,4-D 3 WAT. Overall, efficacy of POST herbicides was better on rosette plants than on bolted plants. Amino acid synthesis and glutamine synthase inhibitors were more active than herbicides with other modes of action. These results indicate that norflurazon, clomazone, fluometuron, flumioxazin, halosulfuron, chlorimuron, and trifloxysulfuron could provide effective control of ragweed parthenium.