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Although medical advancements have improved the mortality of CHD, morbidity still exists, impacting patient quality of life. Returning to baseline in the early surgical recovery phase is an area of potential improvement. This preliminary project aims to qualitatively understand CHD family perspectives concerning the immediate postoperative recovery phase. The participating patients enrolled in the Enhanced Recovery After Surgery program, a postsurgical symptom management tool utilised in adult centres and broadening into pediatrics. Twenty-three of 27 contacted families answered open-ended questions 1 to 3 months postoperatively regarding difficulties experienced during their first week home. They reviewed a list of symptoms including: difficulties with pain, nausea, activity, sleep, appetite, bowel or urinary systems, and taking medications. A qualitative thematic analysis was performed with the open responses, as well as a quantitative assessment of the types of issues that made recovery challenging. Participants struggled most with sleep (78%), returning to activity (70%), and pain (57%). Open-ended responses suggested that an inability to do daily activities, sleep (frequently impacted by pain), and inadequate resources most negatively impacted recovery. Given these findings, investigating postoperative sleep regimens and effective pain plan components may prove useful, in addition to the further development of early mobility programs. The positive and negative experiences highlighting the desire for readily available medical guidance enforce the need for open communication between families and team members, potentially aided by digital tools. Ultimately, further data could support the development of a standardised protocol to better the immediate postoperative quality of life for CHD families.
We investigated the impact of workflow times on the outcomes of patients treated with endovascular thrombectomy (EVT) in the late time window.
Methods:
Individual patients’ data who underwent EVT in the late time window (onset to imaging >6 hours) were pooled from seven registries and randomized clinical trials. Multiple time intervals were analyzed. Mixed-effects logistic regression was used to estimate the likelihood of functional independence at 90 days (modified Rankin Scale 0–2). Mixed-effects negative binomial regression was used to evaluate the relationship between patient characteristics and workflow time intervals.
Results:
608 patients were included. The median age was 70 years (IQR: 58–71), 307 (50.5%) were female, and 310 (53.2%) had wake-up strokes. Successful reperfusion was achieved in 493 (81.2%) patients, and 262 (44.9%) achieved 90-day mRS 0–2. The estimated odds of functional independence decreased by 13% for every 30 minute delay from emergency department (ED) arrival to imaging time and by 7% from ED arrival to the end of EVT in the entire cohort. Also, the estimated odds of functional independence decreased by 33% for every 30 minute delay in the interval from arterial puncture to end of EVT, 16% in the interval from arrival in ED to end of EVT and 6% in the interval from stroke onset to end of EVT among patients who had a wake-up stroke.
Conclusion:
Faster workflow from ED arrival to end of EVT is associated with improved functional independence among stroke patients treated in the late window.
To make informed decisions, assessment theorists, researchers, and practitioners can evaluate the overlap among (1) relevant theories, (2) empirical contributions, and (3) best practices. Unfortunately, such a task may seem daunting due to the so-called science-practice gap, which can thwart collaboration among these parties. This paper presents an epistemology for delineating the importance of integrating these three sources of knowledge. We then apply this epistemology to show that our current knowledge of assessment and development topics are well integrated in some places, but still quite lacking in others.
When the top of a sessile droplet is contacted by an opposing solid surface, the droplet can transfer depending on the wettabilities and relative velocity of the surfaces. What if the surface receiving the liquid was porous? High-speed imaging was used to capture the transfer of a droplet from a solid substrate to an opposing porous surface. The parameters that were varied include the wettability of the donor substrate, the pore size of the receiving surface and the droplet's volume and working fluid. Generally, the transfer process is split into two sequential regimes, wetting and wicking, with wicking being three orders of magnitude longer than wetting on average. The wetting regime is split into two sub-regimes, the donor-independent and donor-dependent regimes. The donor-independent regime follows the dynamics of droplet coalescence, starting in a mass-limited viscous regime followed by a capillary–inertial regime. The donor-dependent regime is driven by a global change in Laplace pressure across the liquid bridge, with the viscous wedge of the receding contact line being the rate-limiting factor. The wicking regime is governed by Darcy's law, completing the transfer process of the droplet.
Evidence-based mass-reach health communication campaigns can increase tobacco cessation, use of cessation resources such as quitlines, and change tobacco-related social norms. These interventions have been associated with a lower likelihood of cigarette smoking relapse in studies conducted internationally; however, no studies have assessed this outcome for a national campaign in the United States. This study examined the relationship between Tips from Former Smokers® (Tips®) campaign exposure and the odds of cigarette smoking relapse among adults who formerly smoked. Using data from the 2014 to 2019 Tips longitudinal campaign surveys, we estimated first episode of relapse (versus remaining a former smoker) as a function of Tips gross rating points (GRPs, a measure of media exposure). Higher levels of Tips GRPs were associated with lower odds of relapse (aOR = 0.63, 95% CI: 0.50-0.78). These results suggest that the Tips campaign may reduce smoking relapse, in addition to the established effect of increasing smoking cessation. Former smokers can be considered a secondary target audience for smoking cessation mass media campaigns, and mass media campaigns could be considered a component of smoking relapse prevention efforts.
As data analytic methods in the managerial sciences become more sophisticated, the gap between the descriptive data typically presented in Table 1 and the analyses used to test the principal hypotheses advanced has become increasingly large. This contributes to several problems including: (1) the increasing likelihood that analyses presented in published research will be performed and/or interpreted incorrectly, (2) an increasing reliance on statistical significance as the principal criterion for evaluating results, and (3) the increasing difficulty of describing our research and explaining our findings to non-specialists. A set of simple methods for assessing whether hypotheses about interventions, moderator relationships and mediation, are plausible that are based on the simplest possible examination of descriptive statistics are proposed.
In 2019, BYK Additives (Widnes, UK; www.byk.com) marked the 55th anniversary of the discovery by Dr Barbara Zsusanna (Susanna) Neumann of the extraordinary product known as Laponite®. The range of Laponite® products developed in the UK during the early 1960s is one of the first examples of truly nanodimensional materials manufactured on an industrial scale, at a time when the field of nanotechnology was only being hinted at (Feynman, 1959). These hectorite-like synthetic nanoclays with very unusual properties have been an enduring commercial success for the UK company that first patented and introduced them to the market, Laporte Industries, which is now a part of the BYK company. The Laponite® brand has proved tremendously popular with academic and industrial scientists worldwide, being cited in >3000 patents and >2500 published academic articles.
The Open Access movement has gathered significant momentum over the last couple of years. This has been instigated largely by cOAlition S and those funders which support its aims. Is ‘Read and Publish’ the way forward? Will it work for all publishers? All authors? All subscribers? All readers? This article looks at the history of OA and updates a similar piece from 2013. A detailed glossary of terms is given at the end of the article.
Schizophrenia is a highly heritable disorder with undetermined neurobiological causes. Understanding the impact on brain anatomy of carrying genetic risk for the disorder will contribute to uncovering its neurobiological underpinnings.
Aims
To examine the effect of rare copy number variants (CNVs) associated with schizophrenia on brain cortical anatomy in a sample of unaffected participants from the UK Biobank.
Method
We used regression analyses to compare cortical thickness and surface area (total and across gyri) between 120 unaffected carriers of rare CNVs associated with schizophrenia and 16 670 participants without any pathogenic CNV. A measure of cortical thickness and surface area covariance across gyri was also compared between groups.
Results
Carrier status was associated with reduced surface area (β = −0.020 mm2, P < 0.001) and less robustly with increased cortical thickness (β = 0.015 mm, P = 0.035), and with increased covariance in thickness (carriers z = 0.31 v. non-carriers z = 0.22, P < 0.0005). Associations were mainly present in frontal and parietal areas and driven by a limited number of rare risk alleles included in our analyses (mainly 15q11.2 deletion for surface area and 16p13.11 duplication for thickness covariance).
Conclusions
Results for surface area conformed with previous clinical findings, supporting surface area reductions as an indicator of genetic liability for schizophrenia. Results for cortical thickness, though, argued against its validity as a potential risk marker. Increased structural thickness covariance across gyri also appears related to risk for schizophrenia. The heterogeneity found across the effects of rare risk alleles suggests potential different neurobiological gateways into schizophrenia's phenotype.
For nearly 30 years, the business and scientific press has featured a constant stream of stories about the changing nature of work. While some organizations and occupations have changed substantially in recent years, the belief that such changes are relatively recent or relatively widespread is not well founded. First, the nature and organization of work has evolved continuously over time and the current changes are especially large. Second, there are very large sectors of the economy in which the changes in technology and the organization of work have been minimal. The belief that the nature of work is changing is in large part rooted in the tendency to mistake the brief period of economic stability and highly valued employment in the United Stats that followed the Second World War as the normal state rather than an anomaly. The nature of work is changing and will continue to change, but these changes are part of a long-term set of evolutionary changes, not a sudden or recent innovation.
Dysbiotic gut microbiota have been implicated in human disease. Diet-based therapeutic strategies have been used to manipulate the gut microbiota towards a more favourable profile. However, it has been demonstrated that large inter-individual variability exists in gut microbiota response to a dietary intervention. The primary objective of this study was to investigate whether habitually low dietary fibre (LDF) v. high dietary fibre (HDF) intakes influence gut microbiota response to an inulin-type fructan prebiotic. In this randomised, double-blind, placebo-controlled, cross-over study, thirty-four healthy participants were classified as LDF or HDF consumers. Gut microbiota composition (16S rRNA bacterial gene sequencing) and SCFA concentrations were assessed following 3 weeks of daily prebiotic supplementation (Orafti® Synergy 1; 16 g/d) or placebo (Glucidex® 29 Premium; 16 g/d), as well as after 3 weeks of the alternative intervention, following a 3-week washout period. In the LDF group, the prebiotic intervention led to an increase in Bifidobacterium (P=0·001). In the HDF group, the prebiotic intervention led to an increase in Bifidobacterium (P<0·001) and Faecalibacterium (P=0·010) and decreases in Coprococcus (P=0·010), Dorea (P=0·043) and Ruminococcus (Lachnospiraceae family) (P=0·032). This study demonstrates that those with HDF intakes have a greater gut microbiota response and are therefore more likely to benefit from an inulin-type fructan prebiotic than those with LDF intakes. Future studies aiming to modulate the gut microbiota and improve host health, using an inulin-type fructan prebiotic, should take habitual dietary fibre intake into account.
DPX-79406 was evaluated for POST annual grass weed control in both controlled environment and field experiments. In controlled environment experiments, green foxtail was most susceptible to DPX-79406; whereas yellow foxtail was least susceptible of the species evaluated. DPX-79406 at 12 g/ha completely controlled six leaf black-seeded proso millet, yellow foxtail, green foxtail, and barnyardgrass. In the field, DPX-79406 at 3.0 to 25.0 g/ha effectively controlled annual grass weeds without injury to three- to six-leaf corn. There was more variation in the effectiveness of DPX-79406 applied in the field. Early POST applications provided less weed control than the late application, especially for barnyardgrass, because of weeds emerging after application. As a result, higher doses were sometimes needed for effective control. In weed-free field trials at two sites in 1990 and 1991, corn tolerated doses up to 75 g/ha of DPX-79406 applied at the three- to six-leaf growth stage. However, doses as low as 18.8 g/ha applied at the six- to nine-leaf growth stage reduced grain yield. In 1991, corn tillering increases and height and yield reductions were related linearly to the dose of DPX-79406 applied during later growth stages. DPX-79406 should be applied early POST in order to avoid crop injury while providing effective weed control.
Field studies were conducted during two soybean-corn rotations to evaluate the effect of tillage systems on quackgrass growth and control with and without glyphosate. In the final year of the study, tillage alone (compared to no-till) resulted in 88%, 78%, 64%, and 31% control of quackgrass with fall moldboard plow, spring moldboard plow, fall soil-saver, and spring soil-saver tillage, respectively. When glyphosate was used to control quackgrass, crop yields increased as tillage was reduced and excellent control of quackgrass in no-till was achieved. Increased shoot growth (in moldboard plowed and fall soil-saver tillage plots), exposure of rhizomes in winter (in fall tilled plots), and increased depth of rhizome burial (in spring tilled plots) increased quackgrass control. In general, the total biomass of quackgrass was reduced in drier years. Nonetheless, drought increased crop yield losses caused by quackgrass interference.
Hulless oats are of interest as an alternative to corn and wheat in organic poultry diets because they offer potential to enhance agrobiodiversity and produce locally grown feeds both within and outside of corn-growing regions. Hulless oats are easily certified GM-free and have demonstrated nutritional value for poultry. A feeding study was carried out to examine: (i) the effects of substituting corn, wheat or a fraction of each with hulless oats in organic layer diets, and (ii) the importance of oat variety in feed performance. Productivity and economic implications in the context of current organic markets were explored. Experimental diets included an oat-free control, Oat + corn, Oat + wheat and Oat + corn + wheat, each of which was formulated with three hulless oat varieties, AC Gwen, Paul and Streaker. All but the control diet included oats at 200 g kg−1. Three hundred Hy-Line Brown hens were individually caged and allocated to diets in groups of 10 in a completely randomized design with three replicates per diet. Experimental diets were fed between 24 and 32 weeks of age during which time hen health, egg production and egg quality indicators were monitored. Results indicated that hulless oats had no negative effects on hen health and productivity. On the basis of current organic feed ingredient prices and an estimated cost of USD 533 mt−1 for production of oats in the study region, oat containing diets were more expensive than the oat-free control. In an evaluation of revenue based on current market prices for organic eggs, the additional cost was completely offset by larger egg sizes of hens on oat containing diets. There were no major differences associated with oat variety.
Despite years of research and practice, dissatisfaction with performance appraisal is at an all-time high. Organizations are contemplating changes to their performance management systems, the most controversial of which is whether to eliminate performance ratings. The pros and cons of retaining performance ratings were the subject of a lively, standing-room-only debate at the 2015 Society for Industrial and Organizational Psychology conference in Philadelphia (Adler, 2015). Given the high interest in this topic, this article recaps the points made by the panelists who participated in the debate. The arguments for eliminating ratings include these: (a) the disappointing interventions, (b) the disagreement when multiple raters evaluate the same performance, (c) the failure to develop adequate criteria for evaluating ratings, (d) the weak relationship between the performance of ratees and the ratings they receive, (e) the conflicting purposes of performance ratings in organizations, (f) the inconsistent effects of performance feedback on subsequent performance, and (g) the weak relationship between performance rating research and practice in organizations. The arguments for retaining ratings include (a) the recognition that changing the rating process is likely to have minimal effect on the performance management process as a whole, (b) performance is always evaluated in some manner, (c) “too hard” is no excuse for industrial–organizational (I-O) psychology, (d) ratings and differentiated evaluations have many merits for improving organizations, (e) artificial tradeoffs are driving organizations to inappropriately abandon ratings, (f) the alternatives to ratings may be worse, and (g) the better questions are these: How could performance ratings be improved, and are we conducting the entire performance management process properly? The article closes with questions organizational members have found useful for driving effective performance management reform.
This paper produces new estimates for white and black mortality and fertility at the state level from 1800(20)–2000. It produces new estimates of black and white schooling for this same period. Using a calibrated model of black and white parents, we fit the time series of black and white fertility and schooling. We then produce estimates of the benefits of equal education opportunity for blacks over the period 1820–2000. For the better part of US history, blacks have suffered from less access to schooling for their children than whites. This paper quantifies the magnitude of this discrimination. Our estimates of the welfare cost of this discrimination prior to the Civil War range between 0.5 and 20 times black wealth, and between 0.5 and 10 times black wealth prior to 1960. Further we find that the Civil Rights era was valued by blacks in the South by between 1% to 2% of wealth. Outside of the South, we find significant costs of discrimination prior to 1960, ranging from 6% to 150% of black wealth. For these divisions from 1960–2000, blacks have attained rough parity in schooling access. The welfare magnitudes are similar to the hypothetical gains to blacks if they had white mortality rates. We show that the model’s black and white human capital series are strongly, positively correlated with state output measures, black and white permanent incomes and black and white earnings.
The goal of focal articles in Industrial and Organizational Psychology: Perspectives on Science and Practice is to present new ideas or different takes on existing ideas and stimulate a conversation in the form of comment articles that extend the arguments in the focal article or that present new ideas stimulated by those articles. The two focal articles in this issue stimulated a wide range of reactions and a good deal of constructive input.
The goal of focal articles in Industrial and Organizational Psychology: Perspectives on Science and Practice is to present new ideas or different takes on existing ideas and stimulate a conversation in the form of comment articles that extend the arguments in the focal article or that present new ideas stimulated by those articles. The two focal articles in this issue stimulated a wide range of reactions and a good deal of constructive input.