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Therapeutic hypothermia (TH) is defined as the active lowering of core body temperature with the purpose of preserving organ function. Despite ample animal and clinical data demonstrating a neuroprotective effect from induced hypothermia after cardiac arrest, stroke, and traumatic brain injury, the use of TH in clinical practice remains limited due to side effects, lack of consensus on the ideal duration and goal targeted temperature, and major limitations in infrastructure. The term TH is being replaced by a more specific term “targeted temperature management” (TTM) to represent a range of temperature goals defined as mild (34.5–36.5 °C), moderate (34.5–32 °C), marked (28–32 °C), and profound hypothermia (<28 °C). In this chapter, we will review the different mechanisms, technology, and clinical indications for TH.
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