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2 results

  • Chapter 10 - The role of metabolic genes in sleep regulation

  • from Section 2 - Geneticsof sleep and circadian rhythms
  • Edited by Paul Shaw, Mehdi Tafti, Michael J. Thorpy
  • Book: The Genetic Basis of Sleep and Sleep Disorders
  • Published online: 05 November 2013
  • Print publication: 24 October 2013, pp 91-103

  • Summary

    This chapter discusses traditional metabolic genes that contribute to sleep regulation as well as candidate genes that may govern the systems independently. Inadequate sleep simultaneously modulates the level of multiple hormones that govern metabolism. In general, with sleep deprivation, the following hormones are decreased: insulin, growth hormone (GH), growth hormone releasing hormone (GHRH), and leptin levels. Even though starvation appears to confer fewer detrimental effects with extended waking than sleep deprivation, this response may come with consequences of its own. There are increasing number of proteins that affect sleep and metabolism, but are not classical metabolic genes. One class of genes that links metabolism and sleep is the circadian rhythm genes. It is interesting to note how often the effect of sleep deprivation invokes a starvation-like response from the body and how a starvation or a starvation-like state results in decreased sleep.