OBJECTIVES/GOALS: Clinical and Translational Science Award (CTSA) hubs are launching D&I Science cores to provide resources and services to promote the translation of clinical evidence into practice. We developed a D&I Science Core strategic plan reflecting our research community’s needs by assessing Implementation Science (IS) competencies. METHODS/STUDY POPULATION: The Tufts CTSI D&I Science Core was launched in early 2023. To design services that meet research community needs, we conducted a survey and key informant interviews based on Padek etal.’s list of Implementation Science (IS) competencies. The competencies are organized into four domains (Definition, Background, and Rationale; Theory and Approaches; Design & Analysis; and Practice-Based Considerations) and categorized by expertise level (beginner, intermediate, advanced). Participants who had attended or expressed interest in a D&I interest group were asked via an email survey to rate their level of confidence in completing selected IS-related research activities, about their experience with IS research or practice, and the types of resources, services and training they desired. RESULTS/ANTICIPATED RESULTS: Twenty researchers (20/65, 31%) submitted survey responses and six researchers participated in in-depth interviews. Survey respondents felt most confident in engaging stakeholders in IS research and least confident selecting a model or framework for a study. Results suggest that researcher capacity building is needed to: • Understand IS models and frameworks and their approaches, strengths, and limitations • Select and use models and frameworks in studies • Assemble IS teams and prepare grant proposals Suggestions for resources, services, and training, include: • Customized education to address diverse needs, knowledge levels, and learning styles • Promotion of D&I Core consultations and grant support services • Sharing of successful proposals to help researchers learn how to apply IS methods DISCUSSION/SIGNIFICANCE: A strategic workplan for the D&I Science Core was developed and implemented to address the findings. Initial emphasis is on developing easily accessible resources and timely consultations for investigators new to IS needing to apply these methods in current grant proposals, while also providing training resources for deeper skill building.

Samples from initially smectite-rich Tertiary continental volcaniclastic sediment from the Deer Lodge and Big Hole basins of southwestern Montana show a general decrease in illite/smectite (I/S) expandability with increasing burial depth. The mineralogical trends in cuttings from seven wells are interrupted by discontinuities in which I/S expandability abruptly decreases by 30 to 80%. These discontinuities coincide with stratigraphic unconformities in four wells in which the stratigraphy is known. Core samples show a wide range of I/S expandabilities over short stratigraphic intervals, possibly due to composition, porosity, and permeability variations. Sericite coexists with I/S in the deep core samples. A core sample from 7958 ft (2425 m) contains an R3-ordered I/S having a nearly ideal 3:1 illite: smectite ratio, similar to the mineral tarasovite. The structure of this I/S is dominated by stacks of four 2:1-layer fundamental illite particles and small proportions of thicker particles randomly interstratified among the four-layer particles.

An experimental investigation identifying the effects of surface roughness on the drag coefficient ($C_{D}$) of freely rolling spheres is reported. Although lubrication theory predicts an infinite drag force for an ideally smooth sphere in contact with a smooth wall, finite drag coefficients are obtained in experiments. It is proposed that surface roughness provides a finite effective gap ($G$) between the sphere and panel, resulting in a finite drag force while also allowing physical contact between the sphere and plane. The measured surface roughnesses of both the sphere and panel are combined to give a total relative roughness ($\xi$). The measured $C_{D}$ increases with decreasing $\xi$, in agreement with analytical predictions. Furthermore, the measured $C_{D}$ is also in good agreement with the combined analytical and numerical predictions for a smooth sphere and wall, with a gap approximately equal to the root-mean-square roughness ($R_q$). The accuracy of these predictions decreases for low mean Reynolds numbers ($\overline {Re}$), due to the existence of multiple scales of surface roughness that are not effectively captured by $R_{q}$. Experimental flow visualisations have been used to identify critical flow transitions that have been previously predicted numerically. Path tracking of spheres rolling on two panels with different surface roughnesses indicates that surface roughness does not significantly affect the sphere path or oscillations. Analysis of sphere Strouhal number ($St$) highlights that wake shedding and sphere oscillations are coupled at low $\overline {Re}$ but with increasing $\overline {Re}$, the influence of wake shedding on the sphere path diminishes.

Kaolinite:NaCl intercalates with basal layer dimensions of 0.95 and 1.25 nm have been prepared by direct reaction of saturated aqueous NaCl solution with well-crystallized source clay KGa-1. The intercalates and their thermal decomposition products have been studied by XRD, solid-state 23Na, 27Al, and 29Si MAS NMR, and FTIR. Intercalate yield is enhanced by dry grinding of kaolinite with NaCl prior to intercalation. The layered structure survives dehydroxylation of the kaolinite at 500°–600°C and persists to above 800°C with a resultant tetrahedral aluminosilicate framework. Excess NaCl can be readily removed by rinsing with water, producing an XRD “amorphous” material. Upon heating at 900°C this material converts to a well-crystallized framework aluminosilicate closely related to low-carnegieite, NaAlSiO4, some 350°C below its stability field. Reaction mechanisms are discussed and structural models proposed for each of these novel materials.

In this paper we discuss the dynamics of vorticity at partial-slip boundaries. We consider the total vector circulation, which includes both the total vorticity of the fluid and the slip velocity at the boundary (the interface vortex sheet). The generation of vector circulation is an inviscid process, which does not depend on either viscosity or the slip length at the boundary. Vector circulation is generated by the inviscid relative acceleration between the fluid and the solid, due to either tangential pressure gradients or tangential acceleration of the partial-slip wall. While the slip length does not affect the creation of vector circulation, it governs how vector circulation is distributed between the total vorticity of the fluid and the interface vortex sheet. Specifically, the partial-slip boundary condition prescribes the ratio between boundary vorticity and the strength of the interface vortex sheet, and the viscous boundary flux transfers vector circulation between the interface vortex sheet and the fluid interior to maintain this condition. The interaction between a vortex ring and a partial-slip wall is examined to highlight various aspects of this formulation. For the head-on collision, the quantity of vector circulation diffused into the fluid as secondary vorticity increases as the slip length is decreased, resulting in a stronger secondary vortex and increased rebound of the vortex ring. For the oblique interaction, the extent to which the vortex ring connects to the boundary increases as the slip length is increased.

Community involvement in research is key to translating science into practice, and new approaches to engaging community members in research design and implementation are needed. The Community Scientist Program, established at the MD Anderson Cancer Center in Houston in 2018 and expanded to two other Texas institutions in 2021, provides researchers with rapid feedback from community members on study feasibility and design, cultural appropriateness, participant recruitment, and research implementation. This paper aims to describe the Community Scientist Program and assess Community Scientists' and researchers' satisfaction with the program. We present the analysis of the data collected from 116 Community Scientists and 64 researchers who attended 100 feedback sessions, across three regions of Texas including Northeast Texas, Houston, and Rio Grande Valley between June 2018 and December 2022. Community Scientists stated that the feedback sessions increased their knowledge and changed their perception of research. All researchers (100%) were satisfied with the feedback and reported that it influenced their current and future research methods. Our evaluation demonstrates that the key features of the Community Scientist Program such as follow-up evaluations, effective bi-directional communication, and fair compensation transform how research is conducted and contribute to reducing health disparities.

The Affordable Care Act of 2010 (ACA) was the most significant policy breakthrough to expand health insurance coverage in the USA in 45 years. Culminating a decade-long effort by Republicans to repeal and undermine the ACA, the Trump administration launched a panoply of executive initiatives to sabotage the law. Benefitting from Democratic control of both the House and Senate during its first 2 years, the Biden administration through legislative and executive initiatives made substantial headway in reversing Trump's sabotage and further reinvigorating the ACA. The 2022 elections witnessed a shift in the partisan milieu. Republicans gained control of the House of Representatives; Democrats scored modest gains in state elections. Emphasising two pivotal features of American governance – federalism and the outsized role of the courts – this essay examines the implications of this new partisan context for Biden's efforts to bolster ACA durability prior to the 2024 presidential election.

One challenge for multisite clinical trials is ensuring that the conditions of an informative trial are incorporated into all aspects of trial planning and execution. The multicenter model can provide the potential for a more informative environment, but it can also place a trial at risk of becoming uninformative due to lack of rigor, quality control, or effective recruitment, resulting in premature discontinuation and/or non-publication. Key factors that support informativeness are having the right team and resources during study planning and implementation and adequate funding to support performance activities. This communication draws on the experience of the National Center for Advancing Translational Science (NCATS) Trial Innovation Network (TIN) to develop approaches for enhancing the informativeness of clinical trials. We distilled this information into three principles: (1) assemble a diverse team, (2) leverage existing processes and systems, and (3) carefully consider budgets and contracts. The TIN, comprised of NCATS, three Trial Innovation Centers, a Recruitment Innovation Center, and 60+ CTSA Program hubs, provides resources to investigators who are proposing multicenter collaborations. In addition to sharing principles that support the informativeness of clinical trials, we highlight TIN-developed resources relevant for multicenter trial initiation and conduct.

A comprehensive investigation, using experimental, computational and analytic methods, is reported on the motion of, and the forces on, spheres of different density ratios rolling freely down an incline in a fluid under gravity. The Reynolds number, based on sphere diameter and terminal velocity, ranged up to 1000 for the experiments, and up to 250 for the computer simulations. A modified Reynolds number, incorporating the density ratio, gravitational acceleration and angle of incline, was found to govern the saturated state of the flow. Transition from steady to unsteady flow was sensitive to mass ratio, with lighter spheres undergoing earlier transition. Indeed, positively buoyant spheres develop cross-slope oscillations prior to the onset of shedding. Also of interest, the transition to chaotic wake flow occurs at Reynolds numbers lower than for a sphere forced to roll at a constant speed. In addition to the average sphere motion, flow-induced vibrations were predicted and measured, with quasi-periodic lateral oscillations found to increase as the flow became more unstable, and to decrease with increased density ratio. The study confirms the time-averaged results of a previous experimental study, although closer inspection shows sensitivity to the relative surface roughness of the sphere and plane in experiments; this sensitivity is masked in typical log–log plots of drag against Reynolds number. Physical surface roughness appears to play a role analogous to the necessary imposed gap between the sphere and plane in computations, removing the singularity in drag that would prevent rolling for an incompressible fluid and perfectly smooth surfaces.

This paper proposes a new approach for evaluating numerically the forces and moments applied to a circular cylinder that is immersed in a fluid and which translates and rotates near a plane wall. Under the proposed approach, the flow is decomposed into inner and outer flows. The inner flow represents the flow in the thin interstice between the cylinder and the wall, and is obtained as an analytic expression using lubrication theory. The outer flow represents the flow far from the interstice, which does not depend on the magnitude of the gap between the cylinder and the wall, when the gap is small. The outer flow is obtained using numerical simulation as a function of both the Reynolds number and the slip coefficient. The force and moment coefficients are then obtained, as functions of the Reynolds number, slip coefficient and gap-to-diameter ratio, by combining the inner and outer solutions. Importantly, since the outer flow does not depend on the gap-to-diameter ratio, the parameter space to be explored by numerical simulations is greatly reduced compared to using finite gap ratio simulations. Moreover, the numerical difficulties associated with resolving the interstitial flow are avoided. The proposed approach can be extended to a wide range of rolling bodies, including spherical particles and wheels, and should significantly reduce the computational expense required to model the hydrodynamic forces and predict the subsequent motion of such bodies.

Ocean-driven melt of Antarctic ice shelves is an important control on mass loss from the ice sheet, but is complex to study due to significant variability in melt rates both spatially and temporally. Here we assess the strengths and weakness of satellite and field-based observations as tools for testing models of ice-shelf melt. We discuss how the complementary use of field, satellite and model data can be a powerful but underutilised tool for studying melt processes. Finally, we identify some community initiatives working to collate and publish coordinated melt rate datasets, which can be used in future for validating satellite-derived maps of melt and evaluating processes in numerical simulations.

The Lighthill–Panton and Lyman–Huggins interpretations of vorticity dynamics are extended to the dynamics of enstrophy. There exist two competing definitions of the vorticity current tensor, which describes the flow rate of vorticity in the fluid interior, and the corresponding boundary vorticity flux, which represents the local vorticity creation rate on a boundary. It is demonstrated that each definition of the vorticity current tensor leads to a consistent set of definitions for the enstrophy current, boundary enstrophy flux and the enstrophy dissipation term. This leads to two alternative interpretations of vorticity and enstrophy dynamics: the Lighthill–Panton and Lyman–Huggins interpretations. Although the kinematic evolution of the vorticity and enstrophy fields are the same under each set of definitions, the dynamical interpretation of the motion generally differs. For example, we consider the Stokes flow over a rotating sphere, and find that the flow approaches a steady state where, under the Lyman–Huggins interpretation, there is no enstrophy creation or dissipation. Under the Lighthill–Panton interpretation, however, the steady-state flow features a balance between the continuous generation and subsequent dissipation of enstrophy. Moreover, the Lyman–Huggins interpretation has previously been shown to offer several benefits in understanding the dynamics of vorticity, and therefore it is beneficial to extend this interpretation to the dynamics of enstrophy. For example, the Lyman–Huggins interpretation allows the creation of vorticity, and therefore enstrophy, to be interpreted as an inviscid process, due to the relative acceleration between the fluid and the boundary.

We present observations of the four $^2 \Pi _{3/2}\,J=3/2$ ground-rotational state transitions of the hydroxyl molecule (OH) along 107 lines of sight both in and out of the Galactic plane: 92 sets of observations from the Arecibo telescope and 15 sets of observations from the Australia Telescope Compact Array (ATCA). Our Arecibo observations included off-source pointings, allowing us to measure excitation temperature ($T_{\rm ex}$) and optical depth, while our ATCA observations give optical depth only. We perform Gaussian decomposition using the Automated Molecular Excitation Bayesian line-fitting Algorithm ‘Amoeba’ (Petzler, Dawson, & Wardle 2021, ApJ, 923, 261) fitting all four transitions simultaneously with shared centroid velocity and width. We identify 109 features across 38 sightlines (including 58 detections along 27 sightlines with excitation temperature measurements). While the main lines at 1665 and 1667 MHz tend to have similar excitation temperatures (median $|\Delta T_{\rm ex}({\rm main})|=0.6\,$K, 84% show $|\Delta T_{\rm ex}({\rm main})|<2\,$K), large differences in the 1612 and 1720 MHz satellite line excitation temperatures show that the gas is generally not in LTE. For a selection of sightlines, we compare our OH features to associated (on-sky and in velocity) Hi cold gas components (CNM) identified by Nguyen et al. (2019, ApJ, 880, 141) and find no strong correlations. We speculate that this may indicate an effective decoupling of the molecular gas from the CNM once it accumulates.