The climate crisis requires nations to achieve human well-being with low national levels of carbon emissions. Countries vary from one another dramatically in how effectively they convert resources into well-being, and some nations with low levels of emissions have relatively high objective and subjective well-being. We identify urgent research and policy agendas for four groups of countries with either low or high emissions and well-being indicators. Least studied are those with low well-being and high emissions. Understanding social and political barriers to switching from high-carbon to lower-carbon modes of production and consumption, and ways to overcome them, will be fundamental.

Although high hepatitis C virus (HCV) prevalence has been observed in people who inject drugs (PWID) for decades, research suggests incidence is falling. We examined whether PWIDs’ use of opioid substitution therapy (OST) and their needle-and-syringe sharing behaviour explained HCV incidence. We assessed HCV incidence in 235 PWID in Melbourne, Australia, and performed discrete-time survival with needle-sharing and OST status as independent variables. HCV infection, reinfection and combined infection/reinfection incidences were 7·6 [95% confidence interval (CI) 4·8–11·9], 12·4 (95% CI 9·1–17·0) and 9·7 (95% CI 7·4–12·6) per 100 person-years, respectively. Needle-sharing was significantly associated with higher incidence of naive HCV infection [hazard ratio (HR) 4·9, 95% CI 1·3–17·7] but not reinfection (HR 1·85, 95% CI 0·79–4·32); however, a cross-model test suggested this difference was sample specific. Past month use of OST had non-significant protective effects against naive HCV infection and reinfection. Our data confirm previous evidence of greatly reduced HCV incidence in PWID, but not the significant protective effect of OST on HCV incidence detected in recent studies. Our findings reinforce the need for greater access to HCV testing and prevention services to accelerate the decline in incidence, and HCV treatment, management and support to limit reinfection.

Full numerical simulations of the Navier–Stokes equations for four cases of vertically falling liquid films with three-dimensional surface waves have been performed. Flow conditions are based on several previous experimental studies where the streamwise and spanwise wavelengths were imposed, which we exploit by simulating periodic wave segments. The considered flows are laminar but approach conditions at which intermittent wave-induced turbulence has been observed elsewhere. Working liquids range from water to silicone oil and cover a large interval of the Kapitza number ($\textit {Ka}=18\mbox{--}3923$), which relates capillary to viscous forces. Simulations were performed on a supercomputer, using a finite-volume code and the volume of fluid and continuum surface force methods to account for the multiphase nature of the flow. Our results show that surface waves, consisting of large horseshoe-shaped wave humps concentrating most of the liquid and preceded by capillary ripples on a thin residual film, segregate the flow field into two regions: an inertia-dominated one in the large humps, where the local Reynolds number is up to five times larger than its mean value, and a visco-capillary region, where capillary and/or viscous forces dominate. In the inertial region, an intricate structure of different-scale vortices arises, which is more complicated than film thickness variations there suggest. Conversely, the flow in the visco-capillary region of large-$\textit {Ka} $ fluids is entirely governed by the local free-surface curvature through the action of capillary forces, which impose the pressure distribution in the liquid film. This results in flow separation zones underneath the capillary troughs and a spanwise cellular flow pattern in the region of capillary wave interference. In some cases, capillary waves bridge the large horseshoe humps in the spanwise direction, coupling the two aforementioned regions and leading the flow to oscillate between three- and two-dimensional wave patterns. This persists over long times, as we show by simulations with the low-dimensional model of Scheid et al. (J. Fluid Mech., vol. 562, 2006, pp. 183–222) after satisfactory comparison with our direct simulations at short times. The governing mechanism is connected to the bridging capillary waves, which drain liquid from the horseshoe humps, decreasing their amplitude and wave speed and causing them to retract in the streamwise direction. Overall, it is observed that spanwise flow structures (not accounted for in two-dimensional investigations) are particularly complex due to the absence of gravity in this direction.

Arange of environmental risk factors, with childbirth the most notable, have been associated with the development of pelvic organ prolapse and urinary incontinence. However, indications of genetic influence (positive family histories, ethnic differences) have prompted research into the heritability of measures of pelvic organ descent and joint mobility, which have also been associated with prolapse and incontinence. Genes appear to influence about half of the variation in these measures and, furthermore, the pelvic organ measures are associated with elbow hyperextension at a phenotypic level (r ≈ .2). We examined these measures in young, nulligravid women to determine if their association is due to a common genetic source. Data were collected from 178 Caucasian female co-twins and non-twin sisters, 50 of whom returned to be retested, which allowed reliability to be estimated and unreliable variance to be isolated in the multivariate analyses. Structural equation modeling was used to estimate genetic associations between latent elbow and bladder mobility factors for which heritabilities were estimated to be 0.80 and 0.64 respectively. The association between these factors appeared to be mediated by common genes (genetic r =.48, non-shared environmental r = −.06), with genes influencing latent elbow mobility accounting for 14% of the variation in latent bladder mobility. We speculate that genes influencing connective tissue structure may underlie this association.