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Homocysteine-lowering nutrients may have preventive/ameliorative roles in
To test whether long-term B-vitamin/folate supplementation reduces
Participants were 4331 women (mean age 63.6 years), without prior
depression, from the Women's Antioxidant and Folic Acid Cardiovascular
Study – a randomised controlled trial of cardiovascular disease
prevention among 5442 women. Participants were randomly assigned to
receive a combination of folic acid (2.5mg/d), vitamin B6
(50mg/d) and vitamin B12 (1 mg/d) or a matching placebo.
Average treatment duration was 7 years. The outcome was incident
depression, defined as self-reported physician/clinician-diagnosed
depression or clinically significant depressive symptoms.
There were 524 incident cases. There was no difference between active
v. placebo groups in depression risk (adjusted
relative risk 1.02, 95% CI 0.86–1.21, P = 0.81), despite
significant homocysteine level reduction.
Long-term, high-dose, daily supplementation with folic acid and vitamins
B6 and B12 did not reduce overall depression
risk in mid-life and older women.
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