Natural history museums house numerous previously undescribed species and unknown information hidden in their collections. We describe lower Carboniferous slit-bearing gastropods (order Pleurotomariida, subclass Vetigastropoda; and family Goniasmatidae, subclass Caenogastropoda) from previously unreported gastropod collections made by Jane Longstaff (Jane Donald), one of the pioneering paleontologists of Paleozoic gastropods in the late nineteenth and early twentieth centuries. The gastropods were collected from the Lower Limestone Formation (Visean, Brigantian) near Dalry, Ayrshire, Scotland. The collection consists largely of microgastropods, many of which are unusually well-preserved including delicate ornament and protoconchs (larval shells). Three new pleurotomariidan species are described—Biarmeaspira heidelbergerae new species, Neilsonia seussae new species, Tapinotomaria longstaffae new species—in addition to seven species belonging to Borestus Thomas, 1940, Stegocoelia (Stegocoelia) Donald, 1889, Stegocoelia (Hypergonia) Donald, 1892, Donaldospira Batten, 1966, and Platyzona Knight, 1945. The caenogastropod-type protoconch is documented for the first time in Hypergonia, which is therefore placed in Goniasmatidae. The new data confirm that Neilsonia Thomas, 1940 (type genus of Neilsoniinae) belongs to Pleurotomariida and is distinct from the morphologically convergent Peruvispira Chronic, 1949 (Goniasmatidae). The selenizone morphology is identical in Biarmeaspira Mazaev, 2006 and Baylea de Koninck, 1883 during their early ontogeny, and Biarmeaspira develops an angulation on the selenizone (the diagnostic feature) in late ontogeny. This corroborates earlier suggestions that Biarmeaspira evolved from Baylea. Biarmeaspira heidelbergerae n. sp. is the first Carboniferous record of Biarmeaspira, which was previously only known from the Permian. The angulated selenizone evidently evolved several times in Pleurotomariida and the repeated appearance of this character in different groups (e.g., Phymatopleuridae, Eotomariidae, Pleurotomariidae) needs further studies using phylogenetic methods.

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PET imaging is increasingly recognized as an important diagnostic tool to investigate patients with cognitive disturbances of possible neurodegenerative origin. PET with 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG), assessing glucose metabolism, provides a measure of neurodegeneration and allows a precise differential diagnosis among the most common neurodegenerative diseases, such as Alzheimer’s disease, frontotemporal dementia or dementia with Lewy bodies. PET tracers specific for the pathological deposits characteristic of different neurodegenerative processes, namely amyloid and tau deposits typical of Alzheimer’s Disease, allow the visualization of these aggregates in vivo. [18F]FDG and amyloid PET imaging have reached a high level of clinical validity and are since 2022 investigations that can be offered to patients in standard clinical care in most of Canada.

This article will briefly review and summarize the current knowledge on these diagnostic tools, their integration into diagnostic algorithms as well as perspectives for future developments.

The Reynolds number dependent flow resistance of heterogeneous rough surfaces is largely unknown at present. The present work provides novel reference data for spanwise-alternating sandpaper strips as one idealised case of a heterogeneous rough surface. Experimental data are presented and analysed in direct comparison with drag measurements of homogeneous sandpaper surfaces and numerical simulations. Based on the homogeneous roughness data, the related challenges and sensitivities for the evaluation of roughness functions from experiments and simulations are discussed. A hydraulic channel height is suggested as an alternative measure for the drag impact of rough surfaces in internal flows. For the investigated heterogeneous roughness, it is found that turbulent flow does not exhibit a fully rough flow behaviour, indicating that the assignment of an equivalent sand grain height as commonly applied for homogeneous roughness is not possible. A prediction of the drag behaviour of rough strips based on an average between rough and smooth drag curves appears promising, but requires further refinement to capture the impact of turbulent secondary flows and spatial transients linking smooth and rough surface parts. While turbulent secondary flow induced by the roughness strips yield significant spanwise variation of the mean velocity profile for the investigated rough strips, we show that the spanwise averaged velocity profiles collapse reasonably well with a smooth or homogeneous rough wall flow. This allows to extract a global roughness function from the spanwise averaged flow field in good agreement with the one deduced from global pressure drop measurements.

This study investigated sex differences in Fe status, and associations between Fe status and endurance and musculoskeletal outcomes, in military training. In total, 2277 British Army trainees (581 women) participated. Fe markers and endurance performance (2·4 km run) were measured at the start (week 1) and end (week 13) of training. Whole-body areal body mineral density (aBMD) and markers of bone metabolism were measured at week 1. Injuries during training were recorded. Training decreased Hb in men and women (mean change (–0·1 (95 % CI –0·2, –0·0) and –0·7 (95 % CI –0·9, –0·6) g/dl, both P < 0·001) but more so in women (P < 0·001). Ferritin decreased in men and women (–27 (95 % CI –28, –23) and –5 (95 % CI –8, –1) µg/l, both P ≤ 0·001) but more so in men (P < 0·001). Soluble transferrin receptor increased in men and women (2·9 (95 % CI 2·3, 3·6) and 3·8 (95 % CI 2·7, 4·9) nmol/l, both P < 0·001), with no difference between sexes (P = 0·872). Erythrocyte distribution width increased in men (0·3 (95 % CI 0·2, 0·4)%, P < 0·001) but not in women (0·1 (95 % CI –0·1, 0·2)%, P = 0·956). Mean corpuscular volume decreased in men (–1·5 (95 % CI –1·8, –1·1) fL, P < 0·001) but not in women (0·4 (95 % CI –0·4, 1·3) fL, P = 0·087). Lower ferritin was associated with slower 2·4 km run time (P = 0·018), sustaining a lower limb overuse injury (P = 0·048), lower aBMD (P = 0·021) and higher beta C-telopeptide cross-links of type 1 collagen and procollagen type 1 N-terminal propeptide (both P < 0·001) controlling for sex. Improving Fe stores before training may protect Hb in women and improve endurance and protect against injury.

Psychological and cultural evolutionary accounts of human sociality propose that beliefs in punitive and monitoring gods that care about moral norms facilitate cooperation. While there is some evidence to suggest that belief in supernatural punishment and monitoring generally induce cooperative behaviour, the effect of a deity's explicitly postulated moral concerns on cooperation remains unclear. Here, we report a pre-registered set of analyses to assess whether perceiving a locally relevant deity as moralistic predicts cooperative play in two permutations of two economic games using data from up to 15 diverse field sites. Across games, results suggest that gods’ moral concerns do not play a direct, cross-culturally reliable role in motivating cooperative behaviour. The study contributes substantially to the current literature by testing a central hypothesis in the evolutionary and cognitive science of religion with a large and culturally diverse dataset using behavioural and ethnographically rich methods.

Previous research has revealed that intuitive confidence is an important predictor of how people choose between an intuitive and non-intuitive alternative when faced with information that opposes the intuitive response. In the current study, we investigated the speed of intuition generation as a predictor of intuitive confidence and participant choice in choice conflict situations. Participants predicted the outcomes of several National Basketball Association games, both with and without reference to a point spread. As hypothesized, the faster participants were to predict the outright winner of a game (i.e., generate an intuition) the more likely they were to predict the favourite against the point spread for that game (i.e., endorse the intuitive response). Overall, our findings are consistent with the notion that the speed of intuition generation acts as a determinant of intuitive confidence and a predictor of choice in situations featuring equally valid intuitive and non-intuitive alternatives.

Previous research has demonstrated a link between illusory pattern perception and various irrational beliefs. On this basis, we hypothesized that participants who displayed greater degrees of illusory pattern perception would also be more likely to rate pseudo-profound bullshit statements as profound. We find support for this prediction across three experiments (N = 627) and four distinct measures of pattern perception. We further demonstrate that this observed relation is restricted to illusory pattern perception, with participants displaying greater endorsement of non-illusory patterns being no more likely to rate pseudo-profound bullshit statements as profound. Additionally, this relation is not a product of a general proclivity to rate all statements as profound and is not accounted for by individual differences in analytic thinking. Overall, we demonstrate that individuals with a tendency to go beyond the available data such that they uncritically endorse patterns where no patterns exist are also more likely to create and endorse false-meaning in meaningless pseudo-profound statements. These findings are discussed in the context of a proposed framework that views individuals’ receptivity to pseudo-profound bullshit as, in part, an unfortunate consequence of an otherwise adaptive process: that of pattern perception.

An important open problem is how values are compared to make simple choices. A natural hypothesis is that the brain carries out the computations associated with the value comparisons in a manner consistent with the Drift Diffusion Model (DDM), since this model has been able to account for a large amount of data in other domains. We investigated the ability of four different versions of the DDM to explain the data in a real binary food choice task under conditions of high and low time pressure. We found that a seven-parameter version of the DDM can account for the choice and reaction time data with high-accuracy, in both the high and low time pressure conditions. The changes associated with the introduction of time pressure could be traced to changes in two key model parameters: the barrier height and the noise in the slope of the drift process.

Individuals often assess themselves as being less susceptible to common biases compared to others. This bias blind spot (BBS) is thought to represent a metacognitive error. In this research, we tested three explanations for the effect: The cognitive sophistication hypothesis posits that individuals who display the BBS more strongly are actually less biased than others. The introspection bias hypothesis posits that the BBS occurs because people rely on introspection more when assessing themselves compared to others. The conversational processes hypothesis posits that the effect is largely a consequence of the pragmatic aspects of the experimental situation rather than true metacognitive error. In two experiments (N = 1057) examining 18 social/motivational and cognitive biases, there was strong evidence of the BBS. Among the three hypotheses examined, the conversational processes hypothesis attracted the greatest support, thus raising questions about the extent to which the BBS is a metacognitive effect.

Across four studies participants (N = 818) rated the profoundness of abstract art images accompanied with varying categories of titles, including: pseudo-profound bullshit titles (e.g., The Deaf Echo), mundane titles (e.g., Canvas 8), and no titles. Randomly generated pseudo-profound bullshit titles increased the perceived profoundness of computer-generated abstract art, compared to when no titles were present (Study 1). Mundane titles did not enhance the perception of profoundness, indicating that pseudo-profound bullshit titles specifically (as opposed to titles in general) enhance the perceived profoundness of abstract art (Study 2). Furthermore, these effects generalize to artist-created abstract art (Study 3). Finally, we report a large correlation between profoundness ratings for pseudo-profound bullshit and “International Art English” statements (Study 4), a mode and style of communication commonly employed by artists to discuss their work. This correlation suggests that these two independently developed communicative modes share underlying cognitive mechanisms in their interpretations. We discuss the potential for these results to be integrated into a larger, new theoretical framework of bullshit as a low-cost strategy for gaining advantages in prestige awarding domains.

During the COVID-19 pandemic, public health guidance (e.g., regarding the use ofnon-medical masks) changed over time. Although many revisions were a result ofgains in scientific understanding, we nonetheless hypothesized that makingchanges in guidance salient would negatively affect evaluations of experts andhealth-protective intentions. In Study 1 (N = 300), wedemonstrate that describing COVID-19 guidance in terms of inconsistency (versusconsistency) leads people to perceive scientists and public health authoritiesless favorably (e.g., as less expert). For participants in Canada(n = 190), though not the U.S. (n = 110),making guidance change salient also reduced intentions to download a contacttracing app. In Study 2 (N = 1399), we show that a briefforewarning intervention mitigates detrimental effects of changes in guidance.In the absence of forewarning, emphasizing inconsistency harmed judgments ofpublic health authorities and reduced health-protective intentions, butforewarning eliminated this effect.

This article is a clinical guide which discusses the “state-of-the-art” usage of the classic monoamine oxidase inhibitor (MAOI) antidepressants (phenelzine, tranylcypromine, and isocarboxazid) in modern psychiatric practice. The guide is for all clinicians, including those who may not be experienced MAOI prescribers. It discusses indications, drug-drug interactions, side-effect management, and the safety of various augmentation strategies. There is a clear and broad consensus (more than 70 international expert endorsers), based on 6 decades of experience, for the recommendations herein exposited. They are based on empirical evidence and expert opinion—this guide is presented as a new specialist-consensus standard. The guide provides practical clinical advice, and is the basis for the rational use of these drugs, particularly because it improves and updates knowledge, and corrects the various misconceptions that have hitherto been prominent in the literature, partly due to insufficient knowledge of pharmacology. The guide suggests that MAOIs should always be considered in cases of treatment-resistant depression (including those melancholic in nature), and prior to electroconvulsive therapy—while taking into account of patient preference. In selected cases, they may be considered earlier in the treatment algorithm than has previously been customary, and should not be regarded as drugs of last resort; they may prove decisively effective when many other treatments have failed. The guide clarifies key points on the concomitant use of incorrectly proscribed drugs such as methylphenidate and some tricyclic antidepressants. It also illustrates the straightforward “bridging” methods that may be used to transition simply and safely from other antidepressants to MAOIs.

Wetland sediments are valuable archives of environmental change but can be challenging to date. Terrestrial macrofossils are often sparse, resulting in radiocarbon (14C) dating of less desirable organic fractions. An alternative approach for capturing changes in atmospheric 14C is the use of terrestrial microfossils. We 14C date pollen microfossils from two Australian wetland sediment sequences and compare these to ages from other sediment fractions (n = 56). For the Holocene Lake Werri Berri record, pollen 14C ages are consistent with 14C ages on bulk sediment and humic acids (n = 14), whilst Stable Polycyclic Aromatic Carbon (SPAC) 14C ages (n = 4) are significantly younger. For Welsby Lagoon, pollen concentrate 14C ages (n = 21) provide a stratigraphically coherent sequence back to 50 ka BP. 14C ages from humic acid and >100 µm fractions (n = 13) are inconsistent, and often substantially younger than pollen ages. Our comparison of Bayesian age-depth models, developed in Oxcal, Bacon and Undatable, highlight the strengths and weaknesses of the different programs for straightforward and more complex chrono-stratigraphic records. All models display broad similarities but differences in modeled age-uncertainty, particularly when age constraints are sparse. Intensive dating of wetland sequences improves the identification of outliers and generation of robust age models, regardless of program used.

The interplay between convective, rotational and magnetic forces defines the dynamics within the electrically conducting regions of planets and stars. Yet their triadic effects are separated from one another in most studies, arguably due to the richness of each subset. In a single laboratory experiment, we apply a fixed heat flux, two different magnetic field strengths and one rotation rate, allowing us to chart a continuous path through Rayleigh–Bénard convection (RBC), two regimes of magnetoconvection, rotating convection and two regimes of rotating magnetoconvection, before finishing back at RBC. Dynamically rapid transitions are determined to exist between jump rope vortex states, thermoelectrically driven magnetoprecessional modes, mixed wall- and oscillatory-mode rotating convection and a novel magnetostrophic wall mode. Thus, our laboratory ‘pub crawl’ provides a coherent intercomparison of the broadly varying responses arising as a function of the magnetorotational forces imposed on a liquid-metal convection system.