Techniques for preventing crazyweed toxicity in livestock have generally fallen into two categories: excluding livestock access to infested ranges during early spring and fall, and controlling crazyweed populations through herbicide application. Although picloram has been used to control crazyweed effectively in the past, aminopyralid has shown efficacy at lower application rates, exhibits less potential off-target movement, and has been classified as a reduced-risk product. Differences in the response of silky crazyweed and nontarget grasses and forbs to picloram + 2,4-D and aminopyralid + 2,4-D were investigated. Picloram + 2,4-D was applied at a rate of 0.3 kg ae ha−1 picloram + 1.1 kg ae ha−1 2,4-D, and aminopyralid + 2,4-D was applied at a rate of 0.1 kg ae ha−1 aminopyralid + 1.2 kg ae ha−1 2,4-D. Silky crazyweed canopy cover, number of flowering stalks, plant size, and biomass decreased 15 mo after herbicide treatments (MAT) with average percentage of relative reductions of 92, 95, 90, and 99%, respectively. Crazyweed density decreased by 1.5 ± 0.2 SE plants m−2 and 1.3 ± 0.2 plants m−2, a relative reduction of 95 and 80%, 15 MAT in aminopyralid + 2,4-D– and picloram + 2,4-D–treated plots, respectively. Plots treated with aminopyralid + 2,4-D had 4% lower nontarget forb canopy cover than did picloram + 2,4-D plots 15 MAT. Grass biomass remained similar within treatments over time for control, aminopyralid + 2,4-D and picloram +2,4-D plots, and was similar in all plots 15 MAT. Plots treated with herbicides had, on average, 11% greater grass cover than did control plots 15 MAT (aminopyralid + 2,4-D: 89%; picloram + 2,4-D: 85%; control: 76%).