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Isomerism, also referred to as “heterotaxy” is a complex set of anatomic and functional perturbations. One of the most obvious manifestations of isomerism is the disturbance of organ arrangement, such that the thoracic organs are no longer asymmetric on the left and right. We report the case of a 14-year-old female in whom exercise-induced dyspnea led to a late diagnosis of left isomerism complicated by Abernethy malformation and portopulmonary hypertension. A comprehensive evaluation revealed two anatomic left lungs and hyparterial bronchi, bilateral left atria, an interrupted inferior caval vein with azygos continuation, multiple spleens, sinus node dysfunction, hepatic hypertrophy with focal nodular hyperplasia, and absence of the portal vein. Pulmonary vasodilator therapy was initiated resulting in clinical improvement. This case exhibits unique features including a late diagnosis of isomerism with Abernethy malformation and portopulmonary hypertension. The patient’s presentation, medical workup, and future treatment emphasise the importance of multidisciplinary care in children with complex multisystem disease. We review the multiple cardiac and extracardiac manifestations of isomerism.
Three Georgia feeder cattle teleauction markets were analyzed from 1977 to 1988 to estimate the impacts of cattle characteristics and market conditions on prices. Cattle characteristic price impacts were similar to those in previous studies. The impact of feeder cattle futures price on teleauction price was positive but varied across markets. Optimal lot size ranged from 143 to 276 head. In one market, 14 lots were necessary to generate positive price impacts. Additional buyers were estimated to have a $.30/cwt per buyer impact on price.
This report describes the case of a neonate with d-transposition of the great arteries and severe pulmonary arterial hypertension stabilised in the post-operative period with continuous iloprost nebulisation. To our knowledge, this is the first documented method of treating post-operative severe pulmonary arterial hypertension with continuous inhaled iloprost in a patient with complex CHD. We found this method of delivering the drug very effective in stabilising haemodynamic swings in the setting of severe pulmonary arterial hypertension.
Here, we present a method for the fabrication of silicon (Si) nanowires and Si nanowire-gold nanoparticles (AuNPs) heterostructures for surface-enhanced Raman scattering (SERS) effect. Branched Si nanowires were grown in atmospheric pressure chemical vapor deposition (CVD) process. Further decoration of these nanowires was achieved by a galvanic deposition of gold followed by annealing procedure. This resulted in Si nanowires-AuNPs heterostructures with controlled size and inter-particle spacing. Furthermore, the fabricated heterostructures were studied for Raman signal enhancement of the low concentration (∼10-6 M) dye (Rhodamine 6G, R6G). It was observed that heterostructuring of SiNWs with AuNPs led to improvement of R6G signals as compared to AuNPs dispersed on flat Si substrate.
Complex nanoscale architectures based on gold nanoparticles (AuNPs) can result in spatially-resolved plasmonics. Herein, we demonstrate the growth of silicon nanowires (SiNWs), heterostructures of SiNWs decorated with AuNPs, and SiNWs decorated with graphene shells encapsulated gold nanoparticles (GNPs). The fabrication approach combined CVD growth of nanowires and graphene with direct nucleation of AuNPs. The plasmonic or optical properties of SiNWs and their complex heterostructures were simulated using discrete dipole approximation method. Extinction efficiency spectra peak for SiNW significantly red-shifted (from 512 nm to 597 nm or 674 nm) after decoration with AuNPs, irrespective of the incident wave vector. Finally, SiNW decorated with GNPs resulted in incident wave vector-dependent extinction efficiency peak. For this case, wave vector aligned with the nanowire axial direction showed a broad peak at ∼535 nm. However, significant scattering and no peak was observed when aligned in radial direction of the SiNWs. Such spatially-resolved and tunable plasmonic or optical properties of nanoscale heterostructures hold strong potential for optical sensor and devices.
MarCon (Market-based Constraints) applies market-based
control to distributed constraint problems. It offers a
new approach to distributing constraint problems that avoids
challenges faced by current approaches in some problem
domains, and it provides a systematic method for applying
markets to a wide array of problems. Constraint agents
interact with one another via the variable agents
in which they have a common interest, using expressions
of their preferences over sets of assignments. Each variable
integrates this information from the constraints interested
in it and provides feedback that enables the constraints
to shrink their sets of assignments until they converge
on a solution. MarCon originated in a system for supporting
human product designers, and its mechanisms are particularly
useful for applications integrating human and machine intelligence
to explore implicit constraints. MarCon has been tested
in the domain of mechanical design, in which its set-narrowing
process is particularly useful.
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