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In this paper, we consider the discrete Orlicz chord Minkowski problem and solve the existence of this problem, which is the nontrivial extension of the discrete $L_{p}$ chord Minkowski problem for ${0<p<1}$.
The effects of the evolution of vortices on the aeroacoustics generated by a hovering wing are numerically investigated by using a hybrid method of an immersed boundary–finite difference method for the three-dimensional incompressible flows and a simplified model based on the Ffowcs Williams-Hawkings acoustic analogy. A low-aspect-ratio ($AR=1.5$) rectangular wing at low Reynolds ($Re=1000$) and Mach ($M=0.04$) numbers is investigated. Based on the simplified model, the far-field acoustics is shown to be dominated by the time derivative of the pressure on the wing surface. Results show that vortical structure evolution in the flow fields, which is described by the divergence of the convection term of the incompressible Navier–Stokes equations in a body-fixed reference frame, determines the time derivative of the surface pressure and effectively the far-field acoustics. It dominates over the centrifugal acceleration and Coriolis acceleration terms in determining the time derivative of the surface pressure. The position of the vortex is also found to affect the time derivative of the surface pressure. A scaling analysis reveals that the vortex acoustic source is scaled with the cube of the flapping frequency.
The present study offers a twofold contribution on counter-gradient transport (CGT) of turbulent scalar flux. First, by examining turbulent scalar mixing through synchronized particle image velocimetry and planar laser-induced fluorescence on an inclined jet in cross-flow, we clarify the previously unexplained phenomenon of CGT, revealing key flow structures, their spatial distribution and modelling implications. Statistical analysis identifies two distinct CGT regions: local cross-gradient transport in the windward shear layer and non-local effects near the wall after injection. These behaviours are driven by specific flow structures, namely Kelvin–Helmholtz vortices (local) and wake vortices (non-local), suggesting that scalar flux can be decomposed into a gradient-type term for gradient diffusion and a term for large-eddy stirring. Second, we propose a new approach for reconstruction of turbulent mean flow and scalar fields using continuous adjoint data assimilation (DA). By rectifying model-form errors through anisotropic correction under observational constraints, our DA model minimizes discrepancies between experimental measurements and numerical predictions. As expected, the introduced forcing term effectively identifies regions where traditional models fall short, particularly in the jet centreline and near-wall regions, thereby enhancing the accuracy of the mean scalar field. These enhancements occur not only within the observation region but also in unseen regions, underscoring present DA approach's reliability and practicality for reproducing mean flow behaviours from limited data. These findings lay a solid foundation for adjoint-based model-consistent data-driven methods, offering promising potential for accurately predicting complex flow scenarios like film cooling.
Flow control of a low-aspect-ratio flat-plate heaving wing at an average angle of attack of $10^{\circ }$ by a steady-blowing jet is numerically studied by using a feedback immersed boundary–lattice Boltzmann method. Blowing jets at the leading edge, mid-chord and trailing edge are considered. The wing enjoys the highest lift production with the trailing-edge downstream blowing jet, which improves the average lift by 50.0 % at $Re = 1000$ and 22.9 % at $Re = 5000$ through the enhancement of the tip vortex circulation caused by the increase in the mass flux of the shear layer at the wing tips. This increase in mass flux decreases as $Re$ increases from 1000 to 5000 due to its self-limiting mechanism. A mid-chord vertical blowing jet induces a middle vortex which enhances the lift production but the enhancement is smaller than that of trailing-edge downstream blowing jet. Other jet arrangements do not significantly increase the lift coefficient, but the mid-chord upstream blowing jet experiences a significant reduction in the drag coefficient, leading to an increase of 50.6 % in the average lift-to-drag ratio. The effectiveness of the flow control is not significantly affected by the aspect ratio.
Superhydrophobic (SHPo) surfaces can capture a thin layer of air called a plastron under water to reduce skin friction. Although a ~30 % drag reduction has been recently reported with longitudinal micro-trench SHPo surfaces under a boat and in a towing tank, the results lacked the consistency to establish a clear trend. Designed based on Yu et al. (J. Fluid Mech, vol. 962, 2023, A9), this work develops and tests a series of high-performance SHPo surface coupons that can sustain a pinned plastron underneath a passenger motorboat revamped to reach 14 knots. Importantly, plastrons in a pinned state, not just their existence, are confirmed during flow experiments for the first time. All the drag-reduction data measured on different longitudinal micro-trenches are found to collapse if plotted against slip length in wall units. In comparison, aligned posts and transverse trenches show less and little drag reduction, respectively, confirming the adverse effect of the spanwise slip in turbulent flows. This report not only verifies SHPo surfaces can provide a consistent drag reduction at high speeds in open sea but also shows that one may predict the amount of drag reduction in turbulent flows using the physical slip length obtained for Stokes flows.
Three new species of Gyrodactylus were identified from the body surface of the Triplophysa species from the Qinghai-Tibet Plateau, Gyrodactylus triplorienchili n. sp. on Triplophysa orientalis in northern Tibet, G. yellochili n. sp. on T. sellaefer and T. scleroptera and G. triplsellachili n. sp. on T. sellaefer and T. robusta in Lanzhou Reach of the Yellow River. The three newly identified species share the nemachili group species’ characteristic of having inturning hamulus roots. Gyrodactylus triplorienchili n. sp. shared a quadrate sickle heel and a thin marginal hook sickle, two morphological traits that set them apart from G. yellochili n. sp. However, they may be identified by the distinct shapes of the sickle base and marginal hook sickle point. Gyrodactylus triplsellachili n. sp. had much larger opisthaptoral hard part size than the other two species. The three new species show relatively low interspecific differences of 2.9–5.3% p-distance for ITS1-5.85-ITS2 rDNA sequences. Phylogenetic analysis indicated that the three new species formed a well-supported monophyletic group (bp = 99) with the other nemachili group species.
The AIMTB rapid test assay is an emerging test, which adopted a fluorescence immunochromatographic assay to measure interferon-γ (IFN-γ) production following stimulation of effector memory T cells in whole blood by mycobacterial proteins. The aim of this article was to explore the ability of AIMTB rapid test assay in detecting Mycobacterium tuberculosis (MTB) infection compared with the widely applied QuantiFERON-TB Gold Plus (QFT-Plus) test among rural doctors in China. In total, 511 participants were included in the survey. The concordance between the QFT-Plus test and the AIMTB rapid test assay was 94.47% with a Cohen’s kappa coefficient (κ) of 0.84 (95% CI, 0.79–0.90). Improved concordance between the two tests was observed in males and in participants with 26 or more years of service as rural doctors. The quantitative values of the QFT-Plus test was higher in individuals with a result of QFT-Plus-/AIMTB+ as compared to those with a result of QFT-Plus-/AIMTB- (p < 0.001). Overall, our study found that there was an excellent consistency between the AIMTB rapid test assay and the QFT-Plus test in a Chinese population. As the AIMTB rapid test assay is fast and easy to operate, it has the potential to improve latent tuberculosis infection testing and treatment at the community level in resource-limited settings.
Childhood trauma (CT) increases rates of psychiatric disorders and symptoms, however, the lasting effect of CT into adulthood has little exploration using large-scale samples.
Objectives
This study estimated the prevalence of CT in a large sample of Chinese young adults, examining the risk factors of current psychological symptoms among those with CT experiences.
Methods
117,769 college students were divided into CT and non-CT groups. The propensity score matching method balanced the confounding sociodemographic factors between the two groups, compared to 16 self-reported psychiatric disorders (e.g., depression, anxiety, eating disorder, obsessive-compulsive disorder, autism, social anxiety disorder, post-traumatic stress disorder), and seven current psychiatric symptoms. Hierarchical regression employed the significant risk factors of the seven current psychiatric symptoms.
Results
The prevalence of CT among young adults was 28.76% (95% CI: 28.47–29.04%). Youths with CT experiences reported higher psychiatric disorder rates and current symptom scores (P < 0.001). Sociodemographic factors (females, family disharmony, low socioeconomic status, poor relationship with parents, lower father’s education level) and lifestyle factors (smoking status, alcohol consumption, lack of exercise) were significantly associated with current psychiatric symptoms.
Results
Public health departments and colleges should develop strategies to promote mental health among those who have experienced CT.
Female crabs enter a stage of rapid ovarian development after mating, and cholesterol is a substrate for steroid hormone synthesis. Therefore, in this experiment, an 8-week feeding trial was conducted to investigate the effects of mating treatments (mated crab and unmated crab) and three dietary cholesterol levels (0·09 %, 0·79 % and 1·40 %) on ovarian development, cholesterol metabolism and steroid hormones metabolism of adult female swimming crab (Portunus trituberculatus). The results indicated that crabs fed the diet with 0·79 % cholesterol significantly increased gonadosomatic index (GSI) and vitellogenin (VTG) content than other treatments in the same mating status. Moreover, mated crabs had markedly increased GSI and VTG content in the ovary and hepatopancreas than unmated crabs. The histological observation found that exogenous vitellogenic oocytes appeared in the mated crabs, while previtellogenic oocytes and endogenous vitellogenic oocytes were the primary oocytes in unmated crabs. The transmission electron microscopy analysis showed that when fed diet with 0·79 % cholesterol, the unmated crabs contained more rough endoplasmic reticulum and mated crabs had higher yolk content than other treatments. Furthermore, mating treatment and dietary 0·79 % cholesterol level both promoted cholesterol deposition by up-regulation of the mRNA and protein expression levels of class B scavenger receptors 1 (Srb1), while stimulating the secretion of steroid hormones by up-regulation of the mRNA and protein expression of steroidogenic acute regulatory protein (Star). Overall, the present results indicated that mating behaviour plays a leading role in promoting ovarian development, and dietary 0·79 % cholesterol level can further promote ovarian development after mating.
Systemic changes in multiple diseases may influence the onset of dementia. However, the specific temporality between exposure diseases and dementia remains uncertain.
Aims
By characterising the full spectrum of temporal disease trajectories before dementia, this study aims to yield a global picture of precursor diseases to dementia and to provide detailed instructions for risk management and primary prevention of dementia.
Method
Using the multicentre, community-based prospective UK Biobank, we constructed disease trajectories before dementia utilising the phenome-wide association analysis, paired directional test and association quantification. Stratified disease trajectories were constructed by dementia subtypes, gender, age of diagnosis and Apolipoprotein E (ApoE) status, respectively.
Results
Our study population comprised 434 266 participants without baseline dementia and 4638 individuals with all-cause dementia. In total, 1253 diseases were extracted as potential components of the disease trajectory before dementia. We identified three clusters of disease trajectories preceding all-cause dementia, initiated by circulatory, metabolic and respiratory diseases occurring approximately 5–15 years before dementia. Cerebral infarction or chronic renal failure following chronic ischaemic heart disease was the specific trajectory before vascular dementia. Apolipoprotein E (ApoE) ε4 non-carriers exhibited more complex trajectories compared with carriers. Lipid metabolism disorders remained in the trajectories regardless of dementia subtypes, gender, age of diagnosis and ApoE status.
Conclusions
This study provides a comprehensive view of the longitudinal disease trajectories before dementia and highlights the potential targets of midlife cardiometabolic dysfunction for dementia screening and prevention.
Whether material deprivation-related childhood socio-economic disadvantages (CSD) and care-related adverse childhood experiences (ACE) have different impacts on depressive symptoms in middle-aged and older people is unclear.
Methods
In the Guangzhou Biobank Cohort Study, CSD and ACE were assessed by 7 and 5 culturally sensitive questions, respectively, on 8,716 participants aged 50+. Depressive symptoms were measured by 15-item Geriatric Depression Scale (GDS). Multivariable linear regression, stratification analyses, and mediation analyses were done.
Results
Higher CSD and ACE scores were associated with higher GDS score in dose-response manner (P for trend <0.001). Participants with one point increment in CSD and ACE had higher GDS score by 0.11 (95% confidence interval [CI], 0.09–0.14) and 0.41 (95% CI, 0.35–0.47), respectively. The association of CSD with GDS score was significant in women only (P for sex interaction <0.001; women: β (95% CI)=0.14 (0.11–0.17), men: 0.04 (−0.01 to 0.08)). The association between ACE and GDS score was stronger in participants with high social deprivation index (SDI) (P for interaction = 0.01; low SDI: β (95% CI)=0.36 (0.29–0.43), high SDI: 0.64 (0.48–0.80)). The proportion of association of CSD and ACE scores with GDS score mediated via education was 20.11% and 2.28%.
Conclusions
CSD and ACE were associated with late-life depressive symptoms with dose-response patterns, especially in women and those with low adulthood socio-economic status. Education was a major mediator for CSD but not ACE. Eliminating ACE should be a top priority.
Seed germination is a pivotal period of plant growth and development. This process can be divided into four major stages, swelling absorption, seed coat dehiscence, radicle emergence and radicle elongation. Cupressus gigantea, a tree native to Tibet, China, is characterized by its resistance to stresses such as cold, and drought, and has a high economic and ecological value. Nevertheless, given its unique geographic location, its seeds are difficult to germinate. Therefore, it is crucial to explore the mechanisms involved in seed germination in this species to improve the germination efficiency of its seeds, thereby protecting this high-quality resource. Here, our findings indicate that seed germination was enhanced when exposed to a 6-h/8-h light/dark photoperiod, coupled with a temperature of 20°C. Furthermore, the application of exogenous GA3 (1 mg/ml, about 2.9 mM) stimulated the germination of C. gigantea seeds. Subsequently, proteomics was used to detect changes in protein expression during the four stages of seed germination. We identified 34 differentially expressed proteins (DEPs), including 13 at the radicle pre-emergence stage, and 17 at the radicle elongation stage. These DEPs were classified into eight functional groups, cytoskeletal proteins, energy metabolism, membrane transport, stress response, molecular chaperones, amino acid metabolism, antioxidant system and ABA signalling pathway. Most of them were found to be closely associated with amino acid metabolism. Combined, these findings indicate that, along with temperature and light, exogenous GA3 can increase the germination efficiency of C. gigantea seeds. Our study also offers insights into the changes in protein expression patterns in C. gigantea seeds during germination.
The dynamic charge density of KZnB3O6, which contains edge-sharing BO4 units, has been characterized using laboratory and synchrotron X-ray diffraction techniques. The experimental electron density distribution (EDD) was constructed using the maximum-entropy method (MEM) from single crystal diffraction data obtained at 81 and 298 K. Additionally, MEM-based pattern fitting (MPF) method was employed to refine the synchrotron powder diffraction data obtained at 100 K. Both the room-temperature single crystal diffraction data and the cryogenic synchrotron powder diffraction data reveal an intriguing phenomenon: the edge-shared B2O2 ring exhibits a significant charge density accumulation between the O atoms. Further analysis of high-quality single crystal diffraction data collected at 81 K, with both high resolution and large signal-to-noise ratio, reveals no direct O–O bonding within the B2O2 ring. The experimental EDD of KZnB3O6 obtained aligns with the results obtained from ab-initio calculations. Our work underscores the importance of obtaining high-quality experimental data to accurately determine EDDs.
Echinococcosis poses a significant threat to public health. The Chinese government has implemented prevention and control measures to mitigate the impact of the disease. By analyzing data from the Chinese Center for Disease Control and Prevention and the State Council of the People’s Republic of China, we found that implementation of these measures has reduced the infection rate by nearly 50% between 2004 to 2022 (from 0.3975 to 0.1944 per 100,000 person-years). Nonetheless, some regions still bear a significant disease burden, and lack of detailed information limites further evaluation of the effects on both alveolar and cystic echinococcosis. Our analysis supports the continuing implementation of these measures and suggests that enhanced wildlife management, case-based strategies, and surveillance systems will facilitate disease control.
Gust response has consistently been a concern in engineering. Critical theories have been proposed in the past to predict the unsteady lift response of an airfoil experiencing vertical gusts by Atassi, and longitudinal gusts by Greenberg. However, their applicability for an airfoil with non-zero angles of attack still needs clarification. Thus, force measurements are conducted to examine these theories’ validity and quasi-steady corrections are applied to compensate potential disparities between the idealised and real flow conditions. Velocity measurements are performed to scrutinise the effect of gusts on the flow around the airfoil, and subsequently to reveal the underlying mechanism governing the airfoil's response to gust-induced perturbations. In the study, two pitching vanes are arranged upstream to generate periodic vertical and longitudinal gusts, whereas a downstream airfoil with angles of attack of 0–12° is subjected to two gust types. It is found that Greenberg's theory demonstrates superior predictive capability in pre-stall regimes, with the potential for its effectiveness to be expanded to post-stall regimes through theoretical refinements. In contrast, Atassi's theory exhibits significant deviations from experimental outcomes across the measured angles of attack. Nevertheless, a modified version of the theory aligns better with experimental results at small angles of attack, whereas substantial discrepancies persist as the angle of attack increases. In the pre-stall regime, the aerodynamic response of the airfoil to vertical gusts displays a linear correlation with the flow angle near the leading edge. In the post-stall regime, the vertical gust induces dynamic stall of the airfoil. The flow angle has an essential effect on the lift coefficient but it alone is inadequate to dictate the trend of the lift coefficient. The vorticity statistics show that negative vortex circulation strongly correlates with the lift coefficient. Thus, further correction of the theory or a new vortex model can be expected to predict the lift variation.
Various magmatisms during the subduction-collision process are crucial to reveal the long-term tectonic evolution of the eastern Central Asian Orogenic Belt. In this paper, we present major and trace elements of whole-rock, zircon U-Pb dating and Hf isotope of the Shanmen pluton. Results imply that the Shanmen pluton consists of quartz diorite and mylonitic granite, with zircon U-Pb ages of 263.7–259.6 Ma. The studied quartz diorite contains high Sr/Y (51.19–90.87) and (La/Yb)N (7.82–13.62) ratios, and belongs to adakitic rocks. Coupled with the positive εHf(t) values of +5.71 to +12.8 with no obvious Eu anomaly, we propose that quartz diorite is the product of the interaction between different degrees of slab melt and the overlying mantle wedge. In contrast, the mylonitic granite has lower MgO (0.28 wt% – 0.47 wt%) contents and positive εHf(t) values of +7.79 to +10.15, indicating an affinity with I-type granite originated by partial melting of the intermediate-basic lower crust. The geochemical characteristics and lithological assemblages, along with the Permian magmatic rocks in the Changchun-Kaiyuan area displaying arc rocks affinity, propose their formation is related to the southward subduction of the Paleo-Asian Ocean (PAO). Based on this study and previous evidence, we lean towards adopting a middle-late Permian slab break-off model, wherein the PAO did not close until the late Permian.
This paper provides a review of cyber risk research accomplished in different disciplines, with a primary goal to aid researchers in the field of insurance and actuarial science in identifying potential research gaps as well as leveraging useful models and techniques that have been considered in the literature. We highlight the recent advancements in cyber risk prediction, modeling, management, and insurance achieved in different domains including computer engineering, actuarial science, and business studies. The surveyed works are classified according to their respective modeling approaches, allowing readers to more easily compare the technical aspects of the surveyed works and spot out research gaps based on the research tools of their liking. We conclude this paper with a summary of possible research directions that are identified from the review.
Knowledge of clay mineralogy is essential for understanding the source areas and weathering environments of fluvial sediments, particularly in large reservoirs facing serious problems with sediment deposition, such as the Three Gorges Reservoir (TGR) in east-central China. The purpose of the present study was to identify the sediment provenances and weathering regimes contributing to the sediment load in the TGR by determining the clay-mineral and geochemical compositions of surface sediments during various seasons. X-ray diffractometry and scanning electron microscopy (SEM) were used to identify the clay minerals. The results showed that illite was the dominant mineral, followed in order by kaolinite, chlorite, and montmorillonite. From a mineralogical perspective, distal sources were the main contributors to the TGR sediments, and regional sources (surrounding tributaries) also contributed much during the three seasons, while proximal sources (hillslope soils) supplied sediment in the flood season but not in the other two seasons. The geochemical and hydrological data generally supported the mineralogical results. In the flood season, the chemical indices of the TGR sediments were >0.4, showing that the sediments contained Al-rich illite minerals and experienced intense hydrolysis. In the other two seasons the TGR sediments were enriched in Fe- and Mg-rich illite minerals, resulting from strong physical weathering. Furthermore, precipitation, rather than air temperature or latitude, was the factor that controlled weathering intensity. These findings provide deep insights into the sediment cycle and chemical weathering in this large reservoir basin.
In the present study, acid-modified attapulgite was used, as an adsorbent, to remove as much Cd2+ as possible from aqueous solution. Static adsorption experiments using powdered acid-modified attapulgite, and dynamic adsorption using granular acid-modifed attapulgite, were conducted to explore the practical application of modified attapulgite in the adsorption of Cd2+. The modified attapulgite had a larger specific surface area and thinner fibrous crystals than the unmodified version. No obvious differences were noted, in terms of the crystal structure, between the natural attapulgite and the modified version. The effects of initial concentration, pH, contact time, and ionic strength on the adsorption of Cd2+ were investigated, and the results showed that the adsorption capacity of the modified attapulgite was increased with increasing pH and the initial Cd2+ concentration. The adsorption properties were analyzed by means of dynamic adsorption tests with respect to various Cd2+ concentrations and flow rates. The maximum adsorption capacity of 8.83 mg/g occurred at a flow rate of 1 mL/min and at an initial concentration of 75 mg/L. Because there was better accord between the data and a pseudo-second order model than a pseudo-first-order model, external mass transfer is suggested to be the rate-controlling process. The experimental data were also fitted for the intraparticle diffusion model, implying that the intraparticle diffusion of Cd2+ onto the modified attapulgite was also important for controlling the adsorption process. The Bohart-Adams model was more suitable than the Thomas model for describing the dynamic behavior with respect to the flow rate and the initial Cd2+ concentration. This research provided the theoretical basis for the dynamic adsorption of Cd2+ on the modified attapulgite. Compared to the powdered modified attapulgite, the dynamic adsorption by granular modified attapulgite appeared more favorable in terms of practical application.