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1 results

  • Lack of association between BDNF Val66Met gene polymorphism and late-onset depression in a Chinese Han population
  • Jiayong You, Yonggui Yuan, Yanyan Shi, Zhijun Zhang, Xiangrong Zhang, Hailin Li
  • Journal: Acta Neuropsychiatrica / Volume 21 / Issue 4 / August 2009
  • Published online by Cambridge University Press: 24 June 2014, pp. 186-190
  • View abstract
    Background:

    Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene has been suggested to be associated with major depressive disorder (MDD). There were a few reports of the relationship between the variant and late-onset depression (LOD) in Chinese Han population.

    Objective:

    To investigate the relationship among BDNF Val66Met gene variants, BDNF plasma level and LOD.

    Methods:

    Chinese Han patients with LOD (n = 99) and control subjects (n = 110) were assessed for BDNF Val66Met gene polymorphism. BDNF plasma level was tested only in LOD.

    Results:

    There were no significant differences in genotypes and allele frequencies between cases and controls (p = 0.744 and p = 0.845, respectively). Plasma BDNF level also did not show significant differences in three genotypes in LOD (p = 0.860).

    Conclusion:

    The Val66Met polymorphism in BDNF gene may not confer susceptibility to LOD in Chinese Han population.