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3 results

  • Case 16 - Personality disintegration – it runs in the family

  • Edited by Serge Gauthier, McGill University, Montréal, Pedro Rosa-Neto, McGill University, Montréal
  • Book: Case Studies in Dementia
  • Published online: 16 May 2011
  • Print publication: 21 April 2011, pp 115-123

  • Summary

    This chapter focuses on visual complaints using the case of a 53-year-old woman who reports difficulties over the past 6 months in handling her work as a specialized clothes cutter in a garment factory. A quantified regional perfusion study using 99mTc SPECT eleven months after onset of symptoms showed significant hypoperfusion of the left parieto-temporal regions and very slight of the right parietal region. This was unchanged on repeat examination eight months later. The initial diagnostic impression was a focal cognitive deficit related to early Alzheimer's disease, non-familial. Atypical presentations of Alzheimer's disease account for about 15% of cases. This case falls under the umbrella of posterior cortical atrophy, first described by Benson et al. in 1988, usually presenting with visuospatial difficulties including visual fields defects. Donepezil was given and well tolerated up to 10 mg a day.