A 3-year study was conducted in irrigated potato to compare weed control efficacy and economics of hilling plus one or two cultivations with the standard treatment of hilling plus a preemergence application of pendimethalin plus metribuzin. Trials were conducted under both weedy and weed-free conditions. Common lambsquarters and redroot pigweed were present in weedy treatments each year; significant populations of hairy nightshade and green foxtail also were present one year. When weed populations were low or moderate (< 45 plants/m2), total weed biomass in the hilling plus one cultivation treatment was reduced 98 to 99% relative to the weedy control, and U.S. No. 1 tuber yields were equal to the standard treatment. However, when weed populations were high (145 plants/m2), hilling plus one cultivation and hilling plus two cultivations provided only 30% and 61% reduction in weed biomass, respectively, and U.S. No. 1 tuber yields were 35% and 13% less, respectively, than the standard treatment. The standard treatment provided 99% reduction in total weed biomass each year, and yields were equal to the weed-free, hill plus no cultivation control. Net return was $37 to $100/ha higher for the hilling plus one cultivation treatment compared to the standard treatment when weed populations were moderate or low, but was $808/ha less than the standard treatment when weed populations were high.