We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Blast waves have been produced in solid target by irradiation with short-pulse high-intensity lasers. The mechanism of production relies on energy deposition from the hot electrons produced by laser–matter interaction, producing a steep temperature gradient inside the target. Hot electrons also produce preheating of the material ahead of the blast wave and expansion of the target rear side, which results in a complex blast wave propagation dynamic. Several diagnostics have been used to characterize the hot electron source, the induced preheating and the velocity of the blast wave. Results are compared to numerical simulations. These show how blast wave pressure is initially very large (more than 100 Mbar), but it decreases very rapidly during propagation.
Declining labor force participation of older men throughout the 20th century and recent increases in participation have generated substantial interest in understanding the effect of public pensions on retirement. The National Bureau of Economic Research's International Social Security (ISS) Project, a long-term collaboration among researchers in a dozen developed countries, has explored this and related questions. The project employs a harmonized approach to conduct within-country analyses that are combined for meaningful cross-country comparisons. The key lesson is that the choices of policy makers affect the incentive to work at older ages and these incentives have important effects on retirement behavior.
This chapter is about the use of direct electrical stimulation with short current pulses to estimate from recorded SEEG responses the functional connectivity of the insula. First, we review some studies of the literature which reported both intra-insular and extra-insular connectivity, using the anterior-posterior gyral decomposition of the insula. Second, we present the mapping of the responses to insula stimulation from 301 patients explored in SEEG from the database of the F-TRACT project. We show that the SEEG responses are highly spatially resolved on the whole brain, as demonstrated when comparing the stimulations between the anterior and posterior parts of the insula at different spatial resolution of the Lausanne parcellation scheme. In general, the responses to electrical stimulation of the insula are particularly numerous, in comparison to the stimulation of other areas, which suggests that insula is a structure densely connected to the rest of the cortex.
Since the 1980s, the Upper Jurassic lithographic limestone of the Causse Méjean (southern France) has been known by local naturalists to yield fossils. However, until the beginning of the 21st century, this plattenkalk remained largely undersampled and scientifically underestimated. Here, we present the results of two decades of prospection and sampling in the Drigas and the Nivoliers quarries. We provide the first palaeontological inventory of the fossil flora, the fauna and the ichnofauna for these localities. The fossil assemblages show the co-occurrence of marine and terrestrial organisms. Marine organisms include algae, bivalves, brachiopods, cephalopods (ammonites, belemnites and coleoids such as Trachyteuthis), echinoderms, decapod crustaceans (ghost shrimps, penaeoid shrimps and glypheoid lobsters) and fishes (including several actinopterygians and a coelacanth). Terrestrial organisms consist of plant remains (conifers, bennettitaleans, pteridosperms) and a single rhynchocephalian (Kallimodon cerinensis). Ichnofossils comprise traces of marine invertebrates (e.g. limulid trackways, ammonite touch mark) as well as coprolites and regurgitalites. Given the exquisite preservation of these fossils, the two quarries can be considered as Konservat-Lagerstätten. Both lithological features and fossil content suggest a calm, protected and shallow-marine environment such as a lagoon partially or occasionally open to the sea. Most fossils are allochthonous to parautochthonous and document diverse ecological habitats. Similarly to other famous Upper Jurassic plattenkalks of western Europe such as Solnhofen, Cerin or Canjuers, the Causse Méjean is a key landmark for our understanding of coastal/lagoonal palaeoecosystems during the Kimmeridgian–Tithonian interval.
The dynamics of coronavirus disease 2019 (COVID-19) seroconversion of hospital employees are understudied. We measured the proportion of seroconverted employees and evaluated risk factors for seroconversion during the first pandemic wave.
Methods:
In this prospective cohort study, we recruited Geneva University Hospitals employees and sampled them 3 times, every 3 weeks from March 30 to June 12, 2020. We measured the proportion of seroconverted employees and determined prevalence ratios of risk factors for seroconversion using multivariate mixed-effects Poisson regression models.
Results:
Overall, 3,421 participants (29% of all employees) were included, with 92% follow-up. The proportion of seroconverted employees increased from 4.4% (95% confidence interval [CI], 3.7%–5.1%) at baseline to 8.5% [(95% CI, 7.6%–9.5%) at the last visit. The proportions of seroconverted employees working in COVID-19 geriatrics and rehabilitation (G&R) wards (32.3%) and non–COVID-19 G&R wards (12.3%) were higher compared to office workers (4.9%) at the last visit. Only nursing assistants had a significantly higher risk of seroconversion compared to office workers (11.7% vs 4.9%; P = .006). Significant risk factors for seroconversion included the use of public transportation (adjusted prevalence ratio, 1.59; 95% CI, 1.25–2.03), known community exposure to severe acute respiratory coronavirus virus 2 (2.80; 95% CI, 2.22–3.54), working in a ward with a nosocomial COVID outbreak (2.93; 95% CI, 2.27–3.79), and working in a COVID-19 G&R ward (3.47; 95% CI, 2.45–4.91) or a non–COVID-19 G&R ward (1.96; 95% CI, 1.46–2.63). We observed an association between reported use of respirators and lower risk of seroconversion (0.73; 95% CI, 0.55–0.96).
Conclusion:
Additional preventive measures should be implemented to protect employees in G&R wards. Randomized trials on the protective effect of respirators are urgently needed.
This work addresses the question of a pertinent macroscale model describing creeping, incompressible and single-phase flow of a Newtonian fluid in an exuding, rigid and homogeneous porous medium. The macroscopic model is derived by upscaling the pore-scale Stokes equations considering a normal mass flux at the solid–fluid interface. The upscaled mass equation shows that the average velocity is non-solenoidal. In addition, the macroscopic momentum equation involves a Darcy term with the classical permeability tensor accounting for macroscopic drag and a correction velocity vector which is a signature of the local fluid displacements induced by the exuding phenomenon. This correction is the sum of a term accounting for the local exuding effect and a compensation term associated with the assumption of spatial periodicity. Both the first term and the permeability tensor are obtained from the solution of the same unique and intrinsic closure problem, which corresponds to that involved in the classical Darcy's law. The upscaled model is validated by comparisons with pore-scale numerical simulations in several illustrative examples. The different configurations evidence the richness of the problem, despite the apparent simplicity of its formulation. The results of this work motivate further investigation about the influence of internal flow sources in transport phenomena in porous media.
Asking psychiatric in-patients about their drug consumption is unlikely to yield reliable results, particularly where alcohol and illicit drug use is involved. The main aim of this study was to compare spontaneous self-reports of drug use in hospitalized psychiatric patients to biological measures of same. A secondary aim was to determine which personal factors were associated with the use of tobacco, alcohol, and illicit drugs as indicated by these biological measures.
Methods
The consumption of substances was investigated using biological measures (urine cotinine, cannabis, opiates, cocaine, amphetamines and barbiturates; blood carbohydrate-deficient transferrin [CDT] and gamma-glutamyl transferase [GGT]) in 486 consecutively admitted psychiatric patients, one day following their hospitalization. Patients’ self-reports of alcohol, tobacco and illicit drugs consumption were recorded. Socio-professional and familial data were also recorded.
Results
The results show a low correlation between biological measures and self-reported consumption of alcohol and illicit drugs. Fifty-two percent of the patients under-reported their consumption of illicit drugs (kappa = .47). Patients with schizophrenia and personality disorders were more likely to disclose their illicit drug consumption relative to patients suffering from mood disorders and alcohol dependence. Fifty-six percent of patients underreported alcohol use, as evaluated by CDT (kappa = .2), and 37% underreported when using the CDT + GGT measure as an indicator. Smoking appeared to be reported adequately. In the study we observed a strong negative correlation between cannabis use and age, a strong correlation between tobacco and cannabis use, and correlations between tobacco, cannabis and alcohol consumption.
Conclusion
This study is the first to compare self-reports and biological measures of alcohol, tobacco and illicit drug uses in a large sample of inpatients suffering from various categories of psychiatric illnesses, allowing for cross-diagnosis comparisons.
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been recently described as an innovative and effective tool for identifying arthropods and mosquito blood meal sources. To test this approach in the context of an entomological survey in the field, mosquitoes were collected from five ecologically distinct areas of Mali. We successfully analysed the blood meals from 651 mosquito abdomens crushed on Whatman filter paper (WFPs) in the field using MALDI-TOF MS. The legs of 826 mosquitoes were then submitted for MALDI-TOF MS analysis in order to identify the different mosquito species. Eight mosquito species were identified, including Anopheles gambiae Giles, Anopheles coluzzii, Anopheles arabiensis, Culex quinquefasciatus, Culex neavei, Culex perexiguus, Aedes aegypti and Aedes fowleri in Mali. The field mosquitoes for which MALDI-TOF MS did not provide successful identification were not previously available in our database. These specimens were subsequently molecularly identified. The WFP blood meal sources found in this study were matched against human blood (n = 619), chicken blood (n = 9), cow blood (n = 9), donkey blood (n = 6), dog blood (n = 5) and sheep blood (n = 3). This study reinforces the fact that MALDI-TOF MS is a promising tool for entomological surveys.
Triatomines are haematophagous insects involved in the transmission of Trypanosoma cruzi, the aetiological agent of Chagas disease. The vector competence of these arthropods can be highly variable, depending on the species. A precise identification is therefore crucial for the epidemiological surveillance of T. cruzi and the determination of at-risk human populations. To circumvent the difficulties of morphological identification and the lack of comprehensiveness of the GenBank database, we hereby propose an alternative method for triatomine identification. The femurs of the median legs of triatomines from eight different species from French Guiana were subjected to matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) analysis. Method evaluation was performed on fresh specimens and was applied to dry specimens collected between 1991 and 2003. Femur-derived protein extracts provided reproducible spectra within the same species along with significant interspecies heterogeneity. Validation of the study by blind test analysis provided 100% correct identification of the specimens in terms of the species, sex and developmental stage. MALDI-TOF mass spectrometry appears to be a powerful tool for triatomine identification, which is a major step forward in the fight against Chagas disease.
In recent years, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has emerged as an efficient tool for arthropod identification. Its application for field monitoring of adult mosquitoes was demonstrated, but identification of larvae has been limited to laboratory-reared specimens. Study aim was to test the success of MALDI-TOF MS in correctly identifying mosquito larvae collected in the field. Collections were performed at 13 breeding sites in urban areas of Marseille, a city in the South of France. A total of 559 larvae were collected. Of these, 73 were accurately morphologically identified, with confirmation either by molecular identification (n = 31) or analysis with MALDI-TOF MS (n = 31) and 11 were tested using both methods. The larvae identified belonged to six species including Culiseta longiareolata, Culex pipiens pipiens, Culex hortensis, Aedes albopictus, Ochlerotatus caspius and Anopheles maculipennis. A high intra-species reproducibility and inter-species specificity of whole larva MS spectra was obtained and was independent of breeding site. More than 92% of the remaining 486 larvae were identified in blind tests against the MS spectra database. Identification rates were lower for early and pupal stages, which is attributed to lower protein abundance and metamorphosis, respectively. The suitability of MALDI-TOF MS for mosquito larvae identification from the field has been confirmed.
The malacofaunas of Burgundy, France, reflect changes in climate and the activities of man during the Holocene. Statistical analyses based on the Shannon diversity index and correspondence analysis are used to describe the mollusk assemblages in a composite sequence based on three well-dated sites. The variation demonstrated by the mollusks suggests that a two-step warming took place between 10,000 and 9000 and 8000 and 6000 yr B.P. in relative agreement with the timing of the deglaciation in the tropical Atlantic Ocean proposed by Mix and Ruddiman (1985, Quaternary Science Reviews 4, 59-108). High humidity, partly associated with widespread inundations of the valleys between 10,000 and 8000 yr B.P., may be related to estimated variations in the rate of freshwater discharge to the Atlantic Ocean reported by Fairbanks (1989, Nature 342, 637-642). The increasing impact of human activities on the environment during the past 2000 yr is indicated by the low diversity of the mollusk assemblages, demonstrating the need for careful interpretation of the youngest Holocene sediments in this region.
A lake-level record of Lake Ledro (northern Italy) spans the entire Holocene with a chronology derived from 51 radiocarbon dates. It is based on a specific sedimentological approach that combines data from five sediment profiles sampled in distinct locations in the littoral zone. On a millennial scale, the lake-level record shows two successive periods from 11,700 to 4500 cal yr BP and from 4500 cal yr BP to the present, characterized by lower and higher average lake levels, respectively. In addition to key seasonal and inter-hemispherical changes in insolation, the major hydrological change around 4500 cal yr BP may be related to a non-linear response of the climate system to orbitally-driven gradual decrease in insolation. The Ledro record questions the notion of an accentuated summer rain regime in the northern Mediterranean borderlands during the boreal insolation maximum. Moreover, the Ledro record highlights that the Holocene was punctuated by successive centennial-scale highstands. Correlations with the Preboreal oscillation and the 8.2 ka event, and comparison with the atmospheric 14C residual record, suggest that short-lived lake-level fluctuations developed at Ledro in response to (1) final steps of the deglaciation in the North Atlantic area and (2) variations in solar activity.
New field investigations of the Achenheim sequence (Alsace, France) allow for the characterization of variations in the low-field magnetic susceptibility over most of the last climatic cycle, i.e., the past 130,000 yr. New stratigraphic data and thermoluminescence measurements permit reassessment of the previous chronological interpretation of the Upper Pleistocene at Achenheim. A high-resolution analysis of magnetic susceptibility discloses the occurrence of a fine-grained “marker” horizon which was also found recently in another section. This horizon is interpreted as a small-scale dust layer deposited prior to the main interval of loess deposition. The horizon, deposited at the marine isotope stage (MIS) 5/4 boundary, has been found in other loess sequences and is especially prevalent in central Europe. It is characterized by low susceptibility values and a grayish color. New thermoluminescence dates indicate that the loess deposition took place after the MIS 5/4 boundary, i.e., after 70,000 yr. These results are consistent with the Greenland GRIP ice-core dust record which also demonstrates a dusty atmosphere after 72,000 yr ago. On a more regional scale, the Achenheim loess sequence demonstrates a reliable correlation between the western side of the Eurasian loess belt and the dust record of the Greenland ice cores.
To describe and analyze a large outbreak of Clostridium difficile 027 (CD-027) infections.
METHODS
Confirmed CD-027 cases were defined as CD infection plus real-time polymerase chain reaction assay (PCR) positive for CD-027. Clinical and microbiological data on patients with CD-027 infection were collected from January 2013 to December 2015 in the Provence-Alpes-Côte-d’Azur region (southeastern France).
RESULTS
In total, 19 healthcare facilities reported 144 CD-027 infections (112 confirmed and 32 probable CD-027 infections) during a 22-month period outbreak. Although the incidence rate per 10,000 bed days was lower in long-term care facilities (LTCFs) than in acute care facilities (0.05 vs 0.14; P<.001), cases occurred mainly in LTCFs, one of which was the probable source of this outbreak. After centralization of CD testing, the rate of confirmed CD-027 cases from LTCFs or residential-care homes increased significantly (69% vs 92%; P<.001). Regarding confirmed CD-027 patients, the sex ratio and the median age were 0.53 and 84.2 years, respectively. The 30-day crude mortality rate was 31%. Most patients (96%) had received antibiotics within 3 months prior to the CD colitis diagnosis. During the study period, the rate of patients with CD-027 (compared with all patients tested in the point-of-care laboratories) decreased significantly (P=.03).
CONCLUSIONS
A large CD-027 outbreak occurred in southeastern France as a consequence of an initial cluster of cases in a single LTCF. Successful interventions included rapid isolation and testing of residents with potentially infectious diarrhea and cohorting of case patients in a specialized infectious diseases ward to optimize management.
The damage and ion distribution induced in Si by an inductively coupled plasma Xe focused ion beam was investigated by atom probe tomography. By using predefined patterns it was possible to prepare the atom probe tips with a sub 50 nm end radius in the ion beam microscope. The atom probe reconstruction shows good agreement with simulated implantation profiles and interplanar distances extracted from spatial distribution maps. The elemental profiles of O and C indicate co-implantation during the milling process. The presence of small disc-shaped Xe clusters are also found in the three-dimensional reconstruction. These are attributed to the presence of Xe nanocrystals or bubbles that open during the evaporation process. The expected accumulated dose points to a loss of >95% of the Xe during analysis, which escapes undetected.
In the current literature, the dispersion relation of parametrically forced surface waves is often identified with that of free unforced waves. We revisit here the theoretical description of Faraday waves, showing that forcing and dissipation play a significant role in the dispersion relation, rendering it bi-valued. We then determine the instability thresholds and the wavenumber selection in cases of both short and long waves. We show that the bifurcation can be either supercritical or subcritical, depending on the depth.
Reducing the spread of multidrug-resistant bacteria in hospitals remains a challenge. Current methods are screening of patients, isolation, and adherence to hygiene measures among healthcare workers (HCWs). More specific measures could rely on a better characterization of the contacts at risk of dissemination.
OBJECTIVE
To quantify how close-proximity interactions (CPIs) affected Staphylococcus aureus dissemination.
DESIGN
Nested case-control study.
SETTING
French long-term care facility in 2009.
PARTICIPANTS
Patients (n=329) and HCWs (n=261).
METHODS
We recorded CPIs using electronic devices together with S. aureus nasal carriage during 4 months in all participants. Cases consisted of patients showing incident S. aureus colonization and were paired to 8 control patients who did not exhibit incident colonization at the same date. Conditional logistic regression was used to quantify associations between incidence and exposure to demographic, network, and carriage covariables.
RESULTS
The local structure of contacts informed on methicillin-resistant S. aureus (MRSA) carriage acquisition: CPIs with more HCWs were associated with incident MRSA colonization in patients (odds ratio [OR], 1.10 [95% CI, 1.04–1.17] for 1 more HCW), as well as longer CPI durations (1.03 [1.01–1.06] for a 1-hour increase). Joint analysis of carriage and contacts showed increased carriage acquisition in case of CPI with another colonized individual (OR, 1.55 [1.14–2.11] for 1 more HCW). Global network measurements did not capture associations between contacts and carriage.
CONCLUSIONS
Electronically recorded CPIs inform on the risk of MRSA carriage, warranting more study of in-hospital contact networks to design targeted intervention strategies.
Infect. Control Hosp. Epidemiol. 2015;36(8):922–929
In the context of the preservation of the cultural heritage, it is important to understand the alteration mechanisms of the materials constituting historical monuments and architecture. Limestone especially is widely used in many French monuments exposed to an urban aggressive atmosphere affecting their durability. To better understand the alteration mechanisms, the first step is to characterize at different scales the stone material properties. In one hand, the pore network that drives the fluids transfer inside the materials was characterized. And on the other hand, the alteration layer formed on several decades aged materials was studied. Results on this fine-scale characterization are discussed.