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To compare sensitivity of specimens for COVID-19 diagnosis, we tested 151 nasopharyngeal/midturbinate swab pairs from 117 COVID-19 inpatients using reverse-transcriptase polymerase chain reaction (RT-PCR). Sensitivity was 94% for nasopharyngeal and 75% for midturbinate swabs (P = .0001). In 88 nasopharyngeal/midturbinate pairs with matched saliva, sensitivity was 86% for nasopharyngeal swabs and 88% for combined midturbinate swabs/saliva.
Surface waves called meniscus waves often appear in systems that are close to the capillary length scale. Since the meniscus shape determines the form of the meniscus waves, the resulting streaming circulation has features distinct from those caused by other capillary–gravity waves recently reported in the literature. In the present study, we produce symmetric and antisymmetric meniscus shapes by controlling boundary wettability and excite meniscus waves by oscillating the meniscus vertically. The symmetric and antisymmetric configurations produce different surface capillary–gravity wave modes and streaming flow structures. The root-mean-square speed of the streaming circulation increases with the second power of the forcing amplitude in both configurations. The flow symmetry of streaming circulation is retained under the symmetric meniscus, while it is lost under the antisymmetric meniscus. The streaming circulation pattern beneath the meniscus observed in our experiments is qualitatively explained using the method introduced by Nicolás & Vega (Fluid Dyn. Res., vol. 32 (4), 2003, pp. 119–139) and Gordillo & Mujica (J. Fluid Mech., vol. 754, 2014, pp. 590–604).
Previous studies have shown that the polymorphisms in COMT gene and environmental factors affect the risk of drug dependence, but there’s no research shown in relapse of heroin dependence, and the mechanism underlying remains uncertain.
Examine the interaction between allelic variants of the catechol-O- methlytransferase (COMT) gene and environmental factors (encountering drug-related environmental situations, social support) in contribution to relapse in heroin dependence.
Construct the gene-environment interaction model in order to understand the mechanism for relapse in heroin dependence.
The 249 heroin dependent subjects who followed up at one year after abstinent by using the natural history interview (NHI), social support rateing Scale (SSRS), and other questionnaires were genotyped for eight tagging single nucleotide polymorphisms (SNP) on the COMT gene. General Multifactor Dimensionality Reduction (GMDR) was used to construct the gene-environment interaction model which impacting relapse in heroin dependence.
The relapse group had higher frequencies of encountering drug-related environment (EDE) and G allele and GG genotype frequencies on COMT gene rs4680 locus and less Social Support Scale scores than that in the abstinence group. Logistic regression analysis showed that encountering more drug-related environment and GG genotype carriers were the risk factors for relapse in heroin dependence. GMDR analysis showed that the COMT gene was interact with the frequency of EDE and social support level to impact the relapse in heroin dependence.
Gene-environment interaction between COMT gene and the frequency of EDE and social support were related to heroin dependence relapse.
Two upper Middle Permian palaeosols, consisting of coal and pyrite intercalated with a 20 cm thick limestone, were found near Mount Emei in the SW Sichuan Basin, China. The macro- and micromorphology and physico-chemical properties, in conjunction with the mineralogical composition of the palaeosol horizons were investigated. This type of palaeosol is common within the Permian intertidal facies of the Upper Yangtze Craton. The section reflects fluctuations within the range of 0–25 m in relative sea-level, with the depositional environment changing from shallow-marine to littoral, followed by tidal-flat to littoral, and finally to continental volcanic rocks, based on a combination of palaeopedological and carbonate microfacies analyses. Such short-term relative sea-level fluctuations in late Middle Permian times in the SW Sichuan Basin of South China are consistent with the long-term falling trend on a global scale in late Middle Permian times, and may be related to regionally variable subsidence and global cooling. The combination of coastal palaeosol and carbonate microfacies analyses is proposed as an additional tool for estimating the amplitude of sea-level changes.
Rumen-protected betaine (RPB) can enhance betaine absorption in the small intestine of ruminants, while betaine can alter fat distribution and has the potential to affect the meat quality of livestock. Hence, we hypothesized that RPB might also affect the meat quality of lambs. Sixty male Hu sheep of similar weight (30.47 ± 2.04 kg) were selected and randomly subjected to five different treatments. The sheep were fed a control diet (control treatment, CTL); 1.1 g/day unprotected-betaine supplemented diet (UPB); or doses of 1.1 g/day (low RPB treatment; L-PB), 2.2 g/day (middle RPB treatment; M-PB) or 3.3 g/day (high RPB treatment; H-PB) RPB-supplemented diet for 70 days. Slaughter performance, meat quality, fatty acid and amino acid content in the longissimus dorsi (LD) muscle, shoulder muscle (SM) and gluteus muscle (GM) were measured. Compared with CTL, betaine (including UPB and RPB) supplementation increased the average daily weight gain (ADG) (P < 0.05) and average daily feed intake (P < 0.01) of lambs. Rumen-protected betaine increased ADG (P < 0.05) compared with UPB. With increasing RPB doses, the eye muscle area of the lambs linearly increased (P < 0.05). Compared with CTL, betaine supplementation decreased water loss (P < 0.05) in SM and increased pH24 in the SM (P < 0.05) and GM (P < 0.05). Compared with UPB, RPB decreased water loss in the GM (P < 0.01), decreased shear force (P < 0.05) in the LD and SM and increased the pH of the meat 24 h after slaughter (pH24). With increasing RPB doses, the shear force and b* value in the LD linearly decreased (P < 0.05), and the pH24 of the meat quadratically increased (P < 0.05). Compared with CTL, betaine supplementation increased the polyunsaturated fatty acid in the GM (P < 0.05). Compared with UPB, RPB supplementation decreased the saturated fatty acid (SFA) content in the LD (P < 0.05) and increased the unsaturated fatty acids (UFA), mono-unsaturated fatty acids and UFA/SFA ratio in the LD (P < 0.05). Compared with CTL, the content of histidine in the LD increased with betaine supplementation. Compared with UPB, RPB supplementation increased the content of total free amino acids and flavor amino acids in the LD of lambs (P < 0.05). With increasing RPB, the isoleucine and phenylalanine contents in the LD linearly increased (P < 0.05). Overall, the data collected indicated that the meat quality of lambs (especially in the LD) improved as a result of betaine supplementation, and RPB showed better effects than those of UPB.
We present studies of the solidification of binary aqueous solutions that undergo time-periodic cooling from below. We develop an experiment for solidification of aqueous
solutions, where the temperature of the cooling boundary is modulated as a simple periodic function of time with independent variations of the modulation amplitude and frequency. The thickness of the mushy layer exhibits oscillations about the background growth obtained for constant cooling. We consider the deviation given by the difference between states with modulated and fixed cooling, which increases when the modulation amplitude increases but decreases with increasing modulation frequency. At early times, the deviation amplitude is consistent with a scaling argument for growth with quasi-steady modulation. In situ measurements of the mush temperature reveal thermal waves propagating through the mushy layer, with amplitude decaying with height within the mushy layer, whilst the phase lag behind the cooling boundary increases with height. This also leads to phase lags in the variation of the mushy-layer thickness compared to the boundary cooling. There is an asymmetry of the deviation of mushy-layer thickness: during a positive modulation (where the boundary temperature increases at the start of a cycle) the peak thickness deviation has a greater magnitude than the troughs in a negative modulation mode (where the boundary temperature decreases at the start of the cycle). A numerical model is formulated to describe mushy-layer growth with constant bulk concentration and turbulent heat transport at the mush–liquid interface driven by compositional convection associated with a finite interfacial solid fraction. The model recovers key features of the experimental results at early times, including the propagation of thermal waves and oscillations in mushy-layer thickness, although tends to overpredict the mean thickness.
We report an experimental study of the distributions of temperature and solid fraction of growing
mushy layers that are subjected to periodical cooling from below, focusing on late-time dynamics where the mushy layer oscillates about an approximate steady state. Temporal evolution of the local temperature
at various heights in the mush demonstrates that the temperature oscillations of the bottom cooling boundary propagate through the mushy layer with phase delays and substantial decay in the amplitude. As the initial concentration
increases, we show that the decay rate of the thermal oscillation with height also decreases, and the propagation speed of the oscillation phase increases. We interpret this as a result of the solid fraction increasing with
, which enhances the thermal conductivity but reduces the specific heat of the mushy layer. We present a new methodology to determine the distribution of solid fraction
in mushy layers for various
, using only measurements of the temperature
. The method is based on the phase behaviour during thermal modulation, and opens up a new approach for inferring mushy-layer properties in geophysical and engineering settings, where direct measurements are challenging. In our experiments, profiles of the solid fraction
exhibit a cliff–ramp–cliff structure with large vertical gradients of
near the mush–liquid interface and also near the bottom boundary, but much more gradual variation in the interior of the mushy layer. Such a profile structure is more pronounced for higher initial concentration
. For very low concentration, the solid fraction appears to be linearly dependent on the height within the mush. The volume-average of the solid fraction, and the local fluctuations in
both increase as
increases. We suggest that the fast increase of
near the bottom boundary is possibly due to diffusive transport of solute away from the bottom boundary and the depletion of solute content near the basal region.
The objective of this work was to describe treatment-emergent sexual dysfunction (TESD) and tolerability following a switch from selective serotonin reuptake inhibitor (SSRI: citalopram, paroxetine, or sertraline) monotherapy to vortioxetine or escitalopram monotherapy in adults with well-treated major depressive disorder (MDD) and SSRI-induced sexual dysfunction.
Data were analyzed from the primary study, an 8-week, randomized, double-blind, head-to-head study in which participants with well-treated depressive symptoms but experiencing TESD with SSRIs were directly switched to flexible doses (10/20 mg) of vortioxetine or escitalopram. Sexual functioning was assessed by the Changes in Sexual Functioning Questionnaire-14 (CSFQ-14), efficacy by the Montgomery–Åsberg Depression Rating Scale scores (MADRS) and Clinicians Global Impression of Severity/Improvement (CGI-S/CGI-I), and tolerability by adverse events. Efficacy and tolerability were assessed by pre-switch SSRI therapy where possible, and by participant characteristics.
Greater improvements in TESD were seen in the vortioxetine compared with escitalopram groups based on: participant demographics (≤45 years, women; P = 0.045), prior SSRI treatment (P = 0.044), number of prior major depressive episodes (MDEs) (1–3; P = 0.001), and duration of prior SSRI therapy (>1 year; P = 0.001). Prior SSRI treatment did not appear to influence the incidence or severity of TEAEs, except for nausea. Regardless of prior SSRI, both treatments maintained antidepressant efficacy after 8 weeks.
Results suggest that vortioxetine is a safe and effective switch therapy for treating SSRI-induced sexual dysfunction in adults with well-treated MDD. Also, improvement in sexual dysfunction with vortioxetine or escitalopram may be influenced by prior SSRI usage, sex, age, and history of MDEs.
Bendamustine hydrochloride monohydrate (marketed as Treanda®) is a nitrogen mustard purine analog alkylator used in the treatment of chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphomas. Commercial bendamustine hydrochloride monohydrate crystallizes in the monoclinic space group P21/c (14), with a = 4.71348(4) Å, b = 47.5325(3) Å, c = 8.97458 (5) Å, β = 96.6515(8)°, V = 1997.161(23) Å3, and Z = 4. A reduced cell search in the Cambridge Structural Database yielded a previously reported crystal structure (Allen, 2002), which did not include hydrogens (Reck, 2006). In this work, the sample was ordered from Santa Cruz Biotechnology, and analyzed as received. The room-temperature crystal structure was refined using synchrotron (λ = 0.413896 Å) powder diffraction data, density functional theory (DFT), and Rietveld refinement techniques. Hydrogen positions were included as part of the structure, and recalculated during the refinement. The diffraction data were collected on beamline BM-11 at the Advanced Photon Source, Argonne National Laboratory. Figure 1 shows the powder X-ray diffraction pattern of the compound. The pattern is included in the Powder Diffraction File as entry 00-064-1508.
Collision between two identical counterflowing gravity currents was studied in the laboratory with the goal of understanding the fundamental turbulent mixing physics of flow collisions in nature, for example katabatic flows and thunderstorm outflows. The ensuing turbulent mixing is a subgrid process in mesoscale forecasting models, and needs to be parameterized using eddy diffusivity. Laboratory gravity currents were generated by simultaneously removing two identical locks, located at both ends of a long rectangular tank, which separated dense and lighter water columns with free surfaces of the same depth
. The frontal velocity
and the velocity and density fields of the gravity currents were monitored using time-resolved particle image velocimetry and planar laser-induced fluorescence imaging. Ensemble averaging of identical experimental realizations was used to compute turbulence statistics, after removing inherent jitter via phase alignment of successive data realizations by iteratively maximizing the cross-correlation of each realization with the ensemble average. Four stages of flow evolution were identified: initial (independent) propagation of gravity currents, their approach while influencing one another, collision and resulting updraughts, and postcollision slumping of collided fluid. The collision stage, in turn, involved three phases, and produced the strongest turbulent mixing as quantified by the rate of change of density. Phase I spanned
, where collision produced a rising density front (interface) with strong shear and intense turbulent kinetic energy production (
is a suitably defined time coordinate such that gravity currents make the initial contact at
). In Phase II (
), the interface was flat and calm with negligible vertical velocity. Phase III (
) was characterized by slumping which led to hydraulic bores propagating away from the collision area. The measurements included root mean square turbulent velocities and their decay rates, interfacial velocity, rate of change of fluid-parcel density, and eddy diffusivity. These measures depended on the Reynolds number
, but appeared to achieve Reynolds number similarity for
. The eddy diffusivity
, space–time averaged over the spatial extent (
) and the lifetime (
) of collision, was
, with the area
of active mixing being
We report on a novel processing route to prepare La0.8Ce0.2(Fe0.95Co0.05)11.8Si1.2/Cu bulk composites by low-temperature hot pressing. With increasing copper content, the compressive strength of the composites first decrease and then increase owing to the buffering effect of copper, but the magnetocaloric effect reduces to some extent. Copper addition improves the thermal conductivity of the composites, which compensates for the decrease in thermal conductivity due to porosity. A relatively large entropy change of 5.75–7.19 J/(kg K) at 2 T near the Curie temperature (249 K), good thermal conductivity of 7.51–15.55 W/(m·K), and improved compressive strength of 151.1–248.0 MPa make these composites attractive magnetic refrigeration materials.
Two new species of egg parasitoids, Oobius saimaensis Yao and Mottern new species and Oobius fleischeri Yao and Duan new species (Hymenoptera: Encyrtidae), are described from eggs of Agrilus fleischeri Obenberger, 1925 (Coleoptera: Buprestidae). Agrilus fleischeri is a phloem-feeding woodborer of poplar (Populus Linnaeus; Salicaceae) in northeastern China. These two species can be distinguished morphologically as O. fleischeri has five tarsomeres and O. saimaensis has four tarsomeres. Although O. saimaensis is morphologically similar to its sympatric congener O. agrili Zhang and Hang, 2005, an important natural enemy of the invasive emerald ash borer, Agrilus planipennis Fairmaire, 1888, molecular phylogenetics and morphological data indicate that they are distinct species. Phylogenetic relationships among the new species and other closely related species are also inferred by using DNA sequence data from several ribosomal and mitochondrial genes. In addition, we expand the known distribution of Oobius primorskyensis Yao and Duan, 2016 to include South Korea.
Surface exfoliation was observed on single-crystal silicon surface under the action of compressed plasma flow (CPF). This phenomenon is mainly attributed to the strong transient thermal stress impact induced by CPF. To gain a better understanding of the mechanism, a micro scale model combined with thermal conduction and linear elastic fracture mechanics was built to analyze the thermal stress distribution after energy deposition. After computation with finite element method, J integral parameter was applied as the criterion for fracture initiation evaluation. It was demonstrated that the formation of surface exfoliation calls for specific material, crack depth, and CPF parameter. The results are potentially valuable for plasma/matter interaction understanding and CPF parameter optimization.
Previously, the concept of Ply Drop Sequence (PDS) is introduced by the authors for the designing of composite laminated structures with multiple regions. Compared to deleting a contiguous innermost/outermost plies in the classical guide-based blending, using PDS is more flexible than dropping plies between adjacent regions. In this article, a new blending model called the Permutation for Panel Sequence (PPS) blending model is proposed to correct the problem of repeated searching of discrete points in the design space for the previous PDS blending model. The proposed method is also applied to an 18-panel horseshoe benchmark problem. The results demonstrate that the useful searching points in the PPS method are less than those in the PDS method when the number of the panels is less than the number of plies in the guide laminate, and the PPS method obtains a faster convergence speed compared with the PDS method.
Little is known about the combined use of benzodiazepines and antidepressants in older psychiatric patients. This study examined the prescription pattern of concurrent benzodiazepines in older adults treated with antidepressants in Asia, and explored its demographic and clinical correlates.
The data of 955 older adults with any type of psychiatric disorders were extracted from the database of the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD) project. Demographic and clinical characteristics were recorded using a standardized protocol and data collection procedure. Both univariate and multiple logistic regression analyses were performed.
The proportion of benzodiazepine and antidepressant combination in this cohort was 44.3%. Multiple logistic regression analysis revealed that higher doses of antidepressants, younger age (<65 years), inpatients, public hospital, major comorbid medical conditions, antidepressant types, and country/territory were significantly associated with more frequent co-prescription of benzodiazepines and antidepressants.
Nearly, half of the older adults treated with antidepressants in Asia are prescribed concurrent benzodiazepines. Given the potentially adverse effects of benzodiazepines, the rationale of benzodiazepines and antidepressants co-prescription needs to be revisited.
The origins and phylogeny of different sheep breeds has been widely studied using polymorphisms within the mitochondrial hypervariable region. However, little is known about the mitochondrial DNA (mtDNA) content and phylogeny based on mtDNA protein-coding genes. In this study, we assessed the phylogeny and copy number of the mtDNA in eight indigenous (population size, n=184) and three introduced (n=66) sheep breeds in China based on five mitochondrial coding genes (COX1, COX2, ATP8, ATP6 and COX3). The mean haplotype and nucleotide diversities were 0.944 and 0.00322, respectively. We identified a correlation between the lineages distribution and the genetic distance, whereby Valley-type Tibetan sheep had a closer genetic relationship with introduced breeds (Dorper, Poll Dorset and Suffolk) than with other indigenous breeds. Similarly, the Median-joining profile of haplotypes revealed the distribution of clusters according to genetic differences. Moreover, copy number analysis based on the five mitochondrial coding genes was affected by the genetic distance combining with genetic phylogeny; we also identified obvious non-synonymous mutations in ATP6 between the different levels of copy number expressions. These results imply that differences in mitogenomic compositions resulting from geographical separation lead to differences in mitochondrial function.
As the strong thermal effect in the surface, intense pulsed ion beam (IPIB) has been extensively used in material surface modification. The ablation is an important part in the interaction process between IPIB and material. In order to investigate the ablation mechanism, combined with IPIB dynamic energy spectrum and infrared imaging diagnostic results, a two-dimensional axisymmetric heat conduction model considering the effect of ablated material was constructed to describe the ablation process and calculate the lost mass of the targets. The influences of beam parameters and ablated matter on the ablation rate were discussed. The experimental and simulative results of ablation threshold and mass were compared.
As a kind of flash heat source, intense pulsed ion beam (IPIB) can be used for material surface modification. The ablation effect has important influence on interaction between IPIB and material. Therefore, the understanding of ablation mechanism is of great significance to IPIB application. In this work, pure zinc targets were irradiated and ablated by IPIB. In the ablation process under the different ion beam energy densities, the ablation products were collected by a monocrystalline silicon substrate. By analyzing the ablation products with scanning electron microscope and energy-dispersive spectrometer, the surface morphology, and the spatial distribution of ablation products quantity were obtained. The results are useful for clearing the ablation process and the influence of beam parameter on the ablation effect.