Abrupt changes in crystal-orientation fabric (COF), and therefore viscosity, are observed near the base of the ice sheet throughout West Antarctica. We report on active-source seismic observations from WAIS Divide, mid-stream and downstream on Thwaites Glacier, and the onset region of Bindschadler Ice Stream. These data reveal a prevalence of englacial seismic reflectivity in the bottom quarter of the ice sheet. The observed seismic reflectivity is complex but largely bed-conformable, with long-spatial-wavelength features observed in the flow direction and short-wavelength features observed across flow. A correspondence of englacial structures with bed features is also observed. We determine the origin of the reflectivity to be abrupt changes in the COF of ice, based on the following: (1) observations of englacial reflectivity are consistent with current knowledge of COF within ice sheets, (2) englacial reflectivity caused by COF contrasts requires the simplest genesis, especially at ice divides, and (3) amplitude analysis shows that the observed englacial reflectivity can be explained by contrasts in seismic velocity due to COF changes. We note that the downstream increase in the quantity and complexity of observations indicates that direct observations of COF at ice divides likely underestimate the role that fabric plays in ice-sheet dynamics.

Metastasis to the tonsils from malignant melanoma is rare. This paper describes one such case in a woman with synchronous breast adenocarcinoma and cutaneous malignant melanoma who had a most unusual clinical course.

Background. Evidence suggests that schizophrenia may be a disorder with origins in early intrauterine mal-development. We have constructed a comprehensive anthropometric scale for the evaluation of dysmorphic features as an index of the nature and timing of developmental disturbance.

Method. A detailed set of craniofacial and bodily measures was compiled and applied to 174 patients with schizophrenia and 80 matched control subjects.

Results. Patients had significantly higher scores on this scale and displayed multiple anomalies of the craniofacial region with an overall narrowing and elongation of the mid-face and lower face. Twelve craniofacial anomalies independently distinguished patients from controls and these variables correctly classified 95% of patients and 80% of control subjects.

Conclusions. This new scale, while procedurally more exacting than the Waldrop scale, more clearly defines the topography of anomalies previously suspected in individuals with schizophrenia. These findings constitute direct evidence for disturbed craniofacial development in schizophrenia and indicate origins in the foetal period during which the characteristic human facial pattern evolves in close association with brain differentiation.