In this prospective, longitudinal study, we examined the risk factors for severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infection among a cohort of chronic hemodialysis (HD) patients and healthcare personnel (HCPs) over a 6-month period. The risk of SARS-CoV-2 infection among HD patients and HCPs was consistently associated with a household member having SARS-CoV-2 infection.

In a prospective cohort of healthcare personnel (HCP), we measured severe acute respiratory syndrome coronavirus virus 2 (SARS-CoV-2) nucleocapsid IgG antibodies after SARS-CoV-2 infection. Among 79 HCP, 68 (86%) were seropositive 14–28 days after their positive PCR test, and 54 (77%) of 70 were seropositive at the 70–180-day follow-up. Many seropositive HCP (95%) experienced an antibody decline by the second visit.

We performed a mixed-methods study to evaluate antimicrobial stewardship program (ASP) uptake and to assess variability of program implementation in Missouri hospitals. Despite increasing uptake of ASPs in Missouri, there is wide variability in both the scope and sophistication of these programs.

Akathisia, dystonia, dyskinesia and parkinsonism, the four main categories of neuroleptic-induced extrapyramidal syndromes (EPS), represent major disadvantages in antipsychotic therapy. In vulnerable patients, acute EPS may progress into potentially irreversible forms such as tardive dystonia and tardive dyskinesia. In the psychiatric clinic, these EPS are often insufficiently recognised or permitted to exist without treatment. In order to ensure a better EPS diagnosis, a simple examination procedure is described. EPS rating scales may serve as an aid in this process. Guidelines are given to prevent and treat EPS. Thus, EPS are best prevented by a course of neuroleptic medication involving as little antidopaminergic D2 effect as possible, including the use of the lowest effective dose (sometimes obtained by addition of a benzodiazepine or carbamazepine) and with antipsychotic drugs which produce low D2 receptor blockade. Treating EPS also consists of using the lowest effective dose and antipsychotics with a low D2 dopamine receptor occupancy. At present, clozapine is the only drug that produces antipsychotic benefits at doses that cause far less D2 receptor antagonism in the basal ganglia of the brain than that seen with standard neuroleptics; however, newer drugs, such as olanzepine, seroquel and sertindole, are on the way.

Westgate Oxford is a commercial redevelopment of a large shopping complex in the center of Oxford, with clients Westgate Oxford Alliance and principal contractor Laing O'Rourke. The excavations, carried out by Oxford Archaeology, between 2014 and 2016, were required as part of UK Planning Guidelines and were the largest ever undertaken in the city and principally focused on a large medieval suburban friary. The project won Best Archaeological Project 2016 at the prestigious national British Archaeological Awards, and the outreach program, which included an evolving pop-up museum, was a significant contributing factor. This essay will demonstrate how to set up a pop-up museum in eight steps. The essay will look at how to work with different partners of a project. It will discuss choosing a story to tell and how to deal with a changing narrative on an archaeological site in “real time.” It will show how the Pop Up museum became the principal location for dissemination for the Westgate Oxford project. The essay will conclude with how to keep the story alive and plans for the future of the Westgate Oxford Pop Up Museum.

The generation of internal gravity waves by a vertically oscillating cylinder that is tilted to the horizontal in a stratified Boussinesq fluid of constant buoyancy frequency, $N$, is investigated. This variant of the widely studied horizontal configuration – where a cylinder aligned with a plane of constant gravitational potential induces four wave beams that emanate from the cylinder, forming a cross pattern known as the ‘St. Andrew’s Cross’ – brings out certain unique features of radiated internal waves from a line source tilted to the horizontal. Specifically, simple kinematic considerations reveal that for a cylinder inclined by a given angle $\unicode[STIX]{x1D719}$ to the horizontal, there is a cutoff frequency, $N\sin \unicode[STIX]{x1D719}$, below which there is no longer a radiated wave field. Furthermore, three-dimensional effects due to the finite length of the cylinder, which are minor in the horizontal configuration, become a significant factor and eventually dominate the wave field as the cutoff frequency is approached; these results are confirmed by supporting laboratory experiments. The kinematic analysis, moreover, suggests a resonance phenomenon near the cutoff frequency as the group-velocity component perpendicular to the cylinder direction vanishes at cutoff; as a result, energy cannot be easily radiated away from the source, and nonlinear and viscous effects are likely to come into play. This scenario is examined by adapting the model for three-dimensional wave beams developed in Kataoka & Akylas (J. Fluid Mech., vol. 769, 2015, pp. 621–634) to the near-resonant wave field due to a tilted line source of large but finite length. According to this model, the combination of three-dimensional, nonlinear and viscous effects near cutoff triggers transfer of energy, through the action of Reynolds stresses, to a circulating horizontal mean flow. Experimental evidence of such an induced mean flow near cutoff is also presented.

Objectives: The Priorities and Evaluation Committee (PEC) funding recommendations for new cancer drugs in British Columbia, Canada have been based on both clinical and economic evidence. The British Columbia Ministry of Health makes funding decisions. We assessed the association between cost-effectiveness of cancer drugs considered from 1998 to 2008 and the subsequent funding decisions.

Methods: All proposals submitted to the PEC between 1998 and 2008 were reviewed, and the association between cost-effectiveness and funding decisions was examined by (i) using logistic regression to test the hypothesis that interventions with higher incremental cost-effectiveness ratios (ICERs) have a lower probability of receiving a positive funding decision and (ii) using parametric and nonparametric tests to determine if a statistically significant difference exists between the mean cost-effectiveness of funded versus not funded proposals. A sub-analysis was conducted to determine if the findings varied across different outcome measures.

Results: Of the 149 proposals reviewed, 78 reported cost-effectiveness using various outcome measures. In the proposals that used life-years gained as the outcome (n = 22), a statistically significant difference of nearly $115,000 was observed between the mean ICERs for funded proposals ($42,006) and for unfunded proposals ($156,967). An odds ratio indicating higher ICERs have a lower probability of being funded was also found to be statistically significant (p < .05).

Conclusions: Economic evidence appears to play a role in British Columbia cancer funding decisions from 1998 to 2008; other decision-making criteria may also have an important role in recommendations and subsequent funding decisions.

The productivity of each component of a sorghum/groundnut intercrop and its constituent sole crops is determined in terms of a ‘Crop Performance Ratio’ (CPR) defined as the productivity of an intercrop per unit area of ground compared with that expected from sole crops sown in the same proportions. The CPR allows productivity, intercepted radiation and seasonal transpiration to be compared so that conversion coefficients for radiation (e; g MJ−1) and dry matter/water ratios (q; g kg−1) can be calculated for each intercrop component and its constituent sole crops. In this experiment, CPR for total dry weight in the intercrop was 1.08 and that for reproductive yield was 1.27. These advantages in overall productivity and yield were typical of those reported elsewhere for sorghum/groundnut intercrops. The proportional increase in total dry matter in the intercrop was largely a result of its greater interception of radiation. The further advantage in reproductive yield was a consequence of an improved harvest index in the sorghum component of the intercrop (0.64) compared with that of its sole crop counterpart (0.55).

Given the ubiquity of layering in environmental stratifications, an interesting example being double-diffusive staircase structures in the Arctic Ocean, we present the results of a joint theoretical and laboratory experimental study investigating the impact of multiple layering on internal wave propagation. We first present results for a simplified model that demonstrates the non-trivial impact of multiple layering. Thereafter, utilizing a weakly viscous linear model that can handle arbitrary vertical stratifications, we perform a comparison of theory with experiments. We conclude by applying this model to a case study of a staircase stratification profile obtained from the Arctic Ocean, finding a rich landscape of transmission behaviour.

We investigate the accuracy achievable on measurements of the the growth rate of structure f(z) using redshift-space distortions (RSD), when (a) these are measured on the group-galaxy cross correlation function; (b) the latter is expanded over a modified version of the conventional spherical armonics, “truncated multipole moments”. Simulation results give first indications that this combination can push systematic errors on f(z) below 3%, using scales r ⩾ 10h−1 Mpc.

A heuristic greedy algorithm is developed for efficiently tiling spatially dense redshift surveys. In its first application to the Galaxy and MassAssembly (GAMA) redshift survey we find it rapidly improves the spatial uniformity of our data, and naturally corrects for any spatial bias introduced by the 2dF multi-object spectrograph. We make conservative predictions for the final state of the GAMA redshift survey after our final allocation of time, and can be confident that even if worse than typical weather affects our observations, all of our main survey requirements will be met.