The four cemeteries of Cyrene were a living archaeological landscape whose life continued far beyond antiquity. The habit of using monumental tombs was a long-lasting one in Cyrene, starting in the Archaic period and continuing until Roman times. The concept of ‘reuse’ is in itself a problematic one since, from a semantic point of view, it implies the presence of a clear-cut division between an original ‘phase of use’ and of a later ‘phase of reuse’. This approach could have sense when a clear hiatus is present, for example when speaking of modern reuse of ancient Greek tombs. However, the main problem is the use of the term ‘reuse’ when describing two ancient phases, such as a Hellenistic phase and a Roman phase of the same tomb, implying a clear hiatus between them even if one often lacks the elements for identifying the existence of such a hiatus. In particular, the Southern and Northern Necropolises have been analysed here to investigate this subject, basing the hypotheses on data coming from field research and previous studies. However, the topic of reuse for the tombs of Cyrene would need far more space than this paper, so this work should be considered an introduction to a matter that needs a far deeper and a far wider analysis. Given these limits, an ‘anthological’ approach is here proposed, with a sequence of various subjects connected to the ‘reuse’ topic and some new data coming from recent research (such as the surveys in the Northern and Southern Necropolises and the excavation of Tomb S1 by the Chieti University team, and of a tomb in the Northern Necropolis by a team of colleagues from the local Department of Antiquities).