There are many structural problems facing the UK at present, from a weakened National Health Service to deeply ingrained inequality. These challenges extend through society to clinical practice and have an impact on current mental health research, which was in a perilous state even before the coronavirus pandemic hit. In this editorial, a group of psychiatric researchers who currently sit on the Academic Faculty of the Royal College of Psychiatrists and represent the breadth of research in mental health from across the UK discuss the challenges faced in academic mental health research. They reflect on the need for additional investment in the specialty and ask whether this is a turning point for the future of mental health research.

California and Washington recently replaced traditional partisan elections with nonpartisan “top-two” election procedures. Some reform advocates hoped that voters would behave in a way to support moderate candidates in the primary stage; the limited evidence for this behaviour has led some scholars to conclude that the reform has little chance to change meaningful policy outcomes. Yet we find that the nonpartisan procedure has predictable and disparate political consequences: the general elections between two candidates of the same party, called copartisan general elections, tend to occur in districts without any meaningful crossparty competition. Furthermore, copartisan elections are more likely to occur with open seats, when a new legislator will begin building a network of relationships. The results, viewed through the lens of the Advocacy Coalition Framework, suggest that opportunities exist for coalitional rearrangement over time.

The use of in vivo X-ray microcomputed tomography (μCT) to study plant root systems has become routine, but is often hampered by poor contrast between roots, soil, soil water, and soil organic matter. In clinical radiology, imaging of poorly contrasting regions is frequently aided by the use of radio-opaque contrast media. In this study, we present evidence for the utility of iodinated contrast media (ICM) in the study of plant root systems using μCT. Different dilutions of an ionic and nonionic ICM (Gastrografin 370 and Niopam 300) were perfused into the aerial vasculature of juvenile pea plants via a leaf flap (Pisum sativum). The root systems were imaged via μCT, and a variety of image-processing approaches used to quantify and compare the magnitude of the contrast enhancement between different regions. Though the treatment did not appear to significantly aid extraction of full root system architectures from the surrounding soil, it did allow the xylem and phloem units of seminal roots and the vascular morphology within rhizobial nodules to be clearly visualized. The nonionic, low-osmolality contrast agent Niopam appeared to be well tolerated by the plant, whereas Gastrografin showed evidence of toxicity. In summary, the use of iodine-based contrast media allows usually poorly contrasting root structures to be visualized nondestructively using X-ray μCT. In particular, the vascular structures of roots and rhizobial nodules can be clearly visualized in situ.

The X-linked telomeric P elements (TPs) TP5 and TP6 regulate the activity of the entire P element family because they are inserted in a major locus for the production of Piwi-interacting RNAs (piRNAs). The potential for this cytotype regulation is significantly strengthened when either TP5 or TP6 is combined with a non-telomeric X-linked or autosomal transgene that contains a P element. By themselves, none of the transgenic P elements have any regulatory ability. Synergism between the telomeric and transgenic P elements is much greater when the TP is derived from a female. Once an enhanced regulatory state is established in a female, it is transmitted to her offspring independently of either the telomeric or transgenic P elements – that is, it works through a strictly maternal effect. Synergistic regulation collapses when either the telomeric or the transgenic P element is removed from the maternal genotype, and it is significantly impaired when the TPs come from stocks heterozygous for mutations in the genes aubergine, piwi or Su(var)205. The synergism between telomeric and transgenic P elements is consistent with a model in which P piRNAs are amplified by alternating, or ping-pong, targeting of primary piRNAs to sense and antisense P transcripts, with the sense transcripts being derived from the transgenic P element and the antisense transcripts being derived from the TP.

The São Tomè Grosbeak Neospiza concolor, previously known from three nineteenth century specimens from the southern part of São Tomè, was rediscovered in August 1991, when two birds were seen in a small clearing above the Rio Xufexufe in the remote forests in the south-west of the island.

Increased partitioning of amino acids (AA) from skeletal muscle to the intestine and immune system during parasitic infection may be the cause of poor growth in parasitised animals. The effect of an established Trichostrongylus colubriformis infection (6000 L3 T. colubriformis larvae for 6 d (n 5) or kept as parasite-free controls (n 6)) on AA fluxes across the mesenteric-drained viscera, portal-drained viscera (PDV), liver, total splanchnic tissues (TSP) and hindquarters were determined in lambs fed fresh Sulla (Hedysarum coronarium; 800 g DM/d) 48 d post-infection. The lambs were infused with ρ-aminohippuric acid (PAH; 723 mg/h) into the mesenteric vein for 8 h to measure TSP plasma flow. Concurrently, indocyanine green (ICG; 14·6 mg/h) was infused into the abdominal aorta to measure plasma flow across the hindquarters. Blood was continuously collected from the mesenteric, portal and hepatic veins, vena cava and the mesenteric artery and plasma harvested. PAH, ICG, AA, metabolite and insulin concentrations were measured. Intestinal worm burdens on day 48 post-infection were higher in the infected lambs (P < 0·05). Plasma flows across the tissue beds were unaffected by parasitic infection (P>0·10). There was a 28 % reduction in the release of AA from the PDV of infected lambs (P < 0·05). The uptakes of most AA were similar in the liver; however, there was increased uptake (P < 0·10) of AA by the TSP of infected lambs. Despite this reduction in AA availability at the liver, there was no effect of parasitic infection on AA uptake across the hindquarters (P < 0·05).

Poor growth during parasitic infection may be due to a redistribution of amino acids away from skeletal muscle protein synthesis to the intestinal site of infection. The effect of a Trichostrongylus colubriformis infection on whole-body amino acid kinetics and tissue fractional protein synthesis rates were determined in lambs fed fresh Sulla (Hedysarum coronarium; 800g DM/d). Lambs were dosed with 6000 L3 Trichostrongylus colubriformis larvae daily for 6d (n 6) or kept as parasite-free controls (n 6). On day 45 post-infection, the lambs received an intravenous injection of 2H2O and infusions (8h) of [35S]sulphate to measure the size of the whole-body water and sulphate pools, respectively. On day 48, the lambs were continuously infused for 8h with [3,4-3H]valine into the jugular vein as well as with [1-13C]valine and [35S]cysteine into the abomasum. After the 8h infusions, the lambs were killed and tissue samples collected from the duodenum, ileum, mesenteric lymph nodes, liver, spleen, thymus, muscle and skin. Feed intake (769 v. 689 (sd 47) g DM/d) was not affected by infection, whereas liveweight gains (50 v. −50 (sd 70) g/d) were lower and intestinal worm burdens(240 v. 18 000 (sd 7000) worms) higher in the infected lambs. Parasitic infection increased the fractional protein synthesis rates in the small intestine, mesenteric lymph nodes and liver but did not affect skin and skeletal muscle fractional protein synthesis rates during the established parasitic infection.

The western Angola Endemic Bird Area has 14 range-restricted species. Little is known about the conservation status of the region's birds due to the civil war that has raged in Angola for the last 27 years. The greatest diversity of restricted-range species is found in Cuanza Sul province, and given the uncertainty about their current status, many of these species are listed as Threatened. In this paper we report the first significant ornithological visits to the Gabela region since 1974. We visited an extensive scarp forest patch at Kumbira Primero, near Conda, as well as smaller forest areas along the Sumbe–Gabela and Sumbe–Seles roads. Most of the threatened species were relocated, including several species not seen since the 1970s. Gabela Bush-shrike Laniarius amboimensis was common and Monteiro's Bush-shrike Malaconotus monteiri was fairly common in degraded secondary forest, old coffee plantations and primary forest at Kumbira. Pulitzer's Longbill Macrosphenus pulitzeri was fairly common at higher elevations at Kumbira as well as in the dense understorey of secondary forest west of Seles. Gabela Akalat Sheppardia gabela was less common, with only three birds found at Kumbira and one near Seles, but may have been overlooked. Only one group of eight Gabela Helmet-shrike Prionops gabela was recorded, in open woodland at the base of the scarp between Kumbira and Seles. Angola Cave-chat Xenocopsychus ansorgei was found on the rocky slopes above the forest at Kumbira. We describe the first sound recordings for five threatened species, which will help future systematic surveys of the region's forests. Vocal evidence confirms the close relationship between Gabela Bush-shrike and Lühder's Bush-shrike L. luehderi. The most pressing need is to assess the extent of remaining forests, map the distribution of key species of conservation concern, and then draft a strategy to conserve key habitat blocks.

Two linked studies assess the feasibility of involving care staff in reducing the prevalence of depression in homes for older people. Mental health training was provided for care staff, delivered by members of a Community Mental Health Team for the Elderly. The research programme used quantitative and qualitative methods to evaluate the effects of a theoretical training for care staff, a system of mentoring care staff to reinforce the training; and a care-planning intervention for the management of depression which combined psychosocial and medical approaches. The training programme was positively evaluated by the recipients, the trainers and the researcher who observed it. The ability of care staff to detect depression improved significantly over time, and depression was reduced to below case-level in seven of the eight depressed residents who participated in the care-planning intervention. This research suggests that psychosocial interventions that involve collaboration between carers and residents, supported by a Community Mental Health Team, may have an important part to play in supplementing medical management of depression in residential care homes.

Given the vulnerability of elderly people living in long-term hospitals and in other forms of institutional provision, it is essential that the quality of their care is as high as possible. This observation, moreover, has widespread relevance irrespective of variations in the structure of health and social care provision in different countries. In pursuit of this objective the newly established ‘arm's length’ inspection units in Britain will be responsible for setting and also safeguarding standards in homes. The article, based on research commissioned by the Social Services Inspectorate, uses a global measure of quality derived from the inspection of residential care homes, examines the correlates of this measure in a sample of local authority and independent homes in Britain and discusses the implications of the findings for policy and further research.

Community schemes play an important part in a community approach to social work. This paper investigates the extent to which social workers' involvement in such schemes is influenced by personal preference or by their work setting. Data from questionnaires completed by 394 social workers/social work assistants show that the likelihood of a worker's involvement with a scheme varies with the organisation and procedures of the area office, the perceived attitudes of team leaders and the title of the worker's job. Workers' personal attitudes were related to involvement in schemes only in area offices organised on a geographical basis. The paper discusses the implications of these findings for the development of a community approach to social work and for the degree to which social workers can expect to control their work as autonomous professionals.