The National Cancer Institute of Canada Clinical Trials Group conducted a phase II trial of trimetrexate given in a daily × 5 intravenous bolus schedule every 3 weeks in patients with measurable recurrent anaplastic glioma and limited prior treatment. There were no responses in 14 evaluable patients. We conclude that trimetrexate, given as described, is not an active agent in this disease.

Mutations in the progranulin gene (GRN) are a common cause of familial frontotemporal dementia. We used a comprehensive neuropsychological battery to investigate whether early cognitive changes could be detected in GRN mutation carriers before dementia onset. Twenty-four at-risk members from six families with known GRN mutations underwent detailed neuropsychological testing. Group differences were investigated by domains of attention, language, visuospatial function, verbal memory, non-verbal memory, working memory and executive function. There was a trend for mutation carriers (n=8) to perform more poorly than non-carriers (n=16) across neuropsychological domains, with significant between group differences for visuospatial function (p<.04; d=0.92) and working memory function (p<.02; d=1.10). Measurable cognitive differences exist before the development of frontotemporal dementia in subjects with GRN mutations. The neuropsychological profile of mutation carriers suggests early asymmetric, right hemisphere brain dysfunction that is consistent with recent functional imaging data from our research group and the broader literature. (JINS, 2014, 20, 1–10)

The recent drive within the UK National Health Service to improve psychosocial care for people with mental illness is both understandable and welcome: evidence-based psychological and social interventions are extremely important in managing psychiatric illness. Nevertheless, the accompanying downgrading of medical aspects of care has resulted in services that often are better suited to offering non-specific psychosocial support, rather than thorough, broad-based diagnostic assessment leading to specific treatments to optimise well-being and functioning. In part, these changes have been politically driven, but they could not have occurred without the collusion, or at least the acquiescence, of psychiatrists. This creeping devaluation of medicine disadvantages patients and is very damaging to both the standing and the understanding of psychiatry in the minds of the public, fellow professionals and the medical students who will be responsible for the specialty's future. On the 200th birthday of psychiatry, it is fitting to reconsider the specialty's core values and renew efforts to use psychiatric skills for the maximum benefit of patients

In 1770 a British official in Madras observed groups composed of men, women, and children who formed “a kind of travelling community of their own under a species of Government peculiar to themselves, with laws and customs which they follow and observe wherever they go”. These itinerant, coveted groups of earth and stone workers – “even courted by Princes” – circulated from worksite to worksite where they dug tanks (small reservoirs), ditches, and wells, and built roads and fortifications. They lived close to their worksites in “temporary hutts which they throw up for the occasion, and always chuse a spot distinct from any village, wandering from one place to another as is most convenient”.

This paper offers a preliminary exploration of the multi-faceted ways in which the railways of South Asia have been represented in textual, aural and visual media. I do this despite my reservations about some representational-type studies presented via language and theories I find opaque. Nonetheless, I do want to signal that I am not a closed-minded trainspotter; I am not one of those railway historians a reviewer of Michael Freeman's Railways and the Victorian Imagination labelled ‘“trainspotters” to a man…combining the enthusiasms of the hobbyist and the econometrician in scholarly mimicry of that singular British type.’ The reviewer, of course, was referring to those railway devotees who haunt British railway stations desperately taking pictures of locomotives and recording their serial numbers and not to the alienated characters in a recent movie of similar name.

To what extent was technological choice within colonial countries deter-mined by requirements or expectations that emanated from interests located within the metropolitan powers? The quick answer, supported by a number of case studies, is that the colonial connection played a major role. The same case studies, however, demonstrate how complex and nuanced the determinants of particular technological choices in particular colonies at particular times were. Moreover, in recent scholarship many facets of the colonial experience have been subjected to considerable deconstruction such that colonialism qua colonialism has lost, for some at least, explanatory power: colonialism has become a background condition, a playing field for the contingent interplay of competing forces and interests located within a colony, a metropole and elsewhere. Without going that far but also without denying the benefits of the richer, more complex understanding deconstruction has brought this paper emphasizes the importance of colonial regimes and colonial labour processes to the analysis of technological choice in colonial contexts. The building and operation of the railways of colonial India provides the content for the arguments that follow. Colonialism as a structure of command and control will be seen to have been a powerful determinant of technological choice for the Indian railways although never independent of other considerations which included, this paper will argue, an important role for Indian railway labour.