For a commutative ring R, we define the notions of deformed Picard algebroids and deformed twisted differential operators on a smooth, separated, locally of finite type R-scheme and prove these are in a natural bijection. We then define the pullback of a sheaf of twisted differential operators that reduces to the classical definition when R = ℂ. Finally, for modules over twisted differential operators, we prove a theorem for the descent under a locally trivial torsor.