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362 results

Page 1 of 19

  • Genesis of the Jinying gold deposit, southern Jilin Province, NE China: Constraints from geochronology and isotope geochemistry

  • Yong Zhang, Yushi Wu, Huali Li, Jilong Han, Quanheng Song
  • Journal:
    Geological Magazine , First View
    Published online by Cambridge University Press:
    16 November 2023, pp. 1-14
    • Article
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  • The Jinying gold deposit is located in southern Jilin Province in northeast China and is representative of the large Early Cretaceous gold deposits in this area. To better understand ore genesis of this deposit, a multi-isotope integrated analysis of U–Pb–Rb–Sr–He–Ar–S has been carried out. Laser ablation inductively coupled plasma–mass spectrometry (LA–ICP–MS) dating of zircons from the granodiorite porphyry and dioritic porphyrite in the study area yields ages of 172.1 ± 1.2 Ma and 122.5 ± 0.8 Ma, suggesting that corresponding intrusion occurred in the Middle Jurassic and the Early Cretaceous. Rb–Sr dating of the pyrite yields an isochron age of 120 ± 3 Ma, suggesting that gold mineralization occurred in the Early Cretaceous. The fluid inclusions in pyrite yield 3He/4He ratios clustered within a small range from 0.08 to 0.13 Ra, 40Ar/36Ar ratios between 331.6 and 351.3, and mantle He in the range of 1.0–1.6%, indicating that the ore-forming fluids originated from a mixed crustal and mantle source. The in situ S isotopic values of pyrite vary between + 0.1 ‰ and + 2.8 ‰, suggesting that the ore-related sulphur came from the deep magmatic source. Combined with the geological history of the study area, it can be concluded that the gold mineralization was possibly related to the extensional setting associated with the rollback of the Palaeo-Pacific Plate.

  • Gray matter atrophy is constrained by normal structural brain network architecture in depression

  • Shaoqiang Han, Keke Fang, Ruiping Zheng, Shuying Li, Bingqian Zhou, Wei Sheng, Baohong Wen, Liang Liu, Yarui Wei, Yuan Chen, Huafu Chen, Qian Cui, Jingliang Cheng, Yong Zhang
  • Journal:
    Psychological Medicine , First View
    Published online by Cambridge University Press:
    10 November 2023, pp. 1-11
  • Background

    There is growing evidence that gray matter atrophy is constrained by normal brain network (or connectome) architecture in neuropsychiatric disorders. However, whether this finding holds true in individuals with depression remains unknown. In this study, we aimed to investigate the association between gray matter atrophy and normal connectome architecture at individual level in depression.

    Methods

    In this study, 297 patients with depression and 256 healthy controls (HCs) from two independent Chinese dataset were included: a discovery dataset (105 never-treated first-episode patients and matched 130 HCs) and a replication dataset (106 patients and matched 126 HCs). For each patient, individualized regional atrophy was assessed using normative model and brain regions whose structural connectome profiles in HCs most resembled the atrophy patterns were identified as putative epicenters using a backfoward stepwise regression analysis.

    Results

    In general, the structural connectome architecture of the identified disease epicenters significantly explained 44% (±16%) variance of gray matter atrophy. While patients with depression demonstrated tremendous interindividual variations in the number and distribution of disease epicenters, several disease epicenters with higher participation coefficient than randomly selected regions, including the hippocampus, thalamus, and medial frontal gyrus were significantly shared by depression. Other brain regions with strong structural connections to the disease epicenters exhibited greater vulnerability. In addition, the association between connectome and gray matter atrophy uncovered two distinct subgroups with different ages of onset.

    Conclusions

    These results suggest that gray matter atrophy is constrained by structural brain connectome and elucidate the possible pathological progression in depression.

Page 1 of 19