With the recent discovery of a dozen dusty star-forming galaxies and around 30 quasars at z > 5 that are hyper-luminous in the infrared (μ LIR > 1013 L⊙, where μ is a lensing magnification factor), the possibility has opened up for SPICA, the proposed ESA M5 mid-/far-infrared mission, to extend its spectroscopic studies toward the epoch of reionisation and beyond. In this paper, we examine the feasibility and scientific potential of such observations with SPICA’s far-infrared spectrometer SAFARI, which will probe a spectral range (35–230 μm) that will be unexplored by ALMA and JWST. Our simulations show that SAFARI is capable of delivering good-quality spectra for hyper-luminous infrared galaxies at z = 5 − 10, allowing us to sample spectral features in the rest-frame mid-infrared and to investigate a host of key scientific issues, such as the relative importance of star formation versus AGN, the hardness of the radiation field, the level of chemical enrichment, and the properties of the molecular gas. From a broader perspective, SAFARI offers the potential to open up a new frontier in the study of the early Universe, providing access to uniquely powerful spectral features for probing first-generation objects, such as the key cooling lines of low-metallicity or metal-free forming galaxies (fine-structure and H2 lines) and emission features of solid compounds freshly synthesised by Population III supernovae. Ultimately, SAFARI’s ability to explore the high-redshift Universe will be determined by the availability of sufficiently bright targets (whether intrinsically luminous or gravitationally lensed). With its launch expected around 2030, SPICA is ideally positioned to take full advantage of upcoming wide-field surveys such as LSST, SKA, Euclid, and WFIRST, which are likely to provide extraordinary targets for SAFARI.

Measurements in the infrared wavelength domain allow direct assessment of the physical state and energy balance of cool matter in space, enabling the detailed study of the processes that govern the formation and evolution of stars and planetary systems in galaxies over cosmic time. Previous infrared missions revealed a great deal about the obscured Universe, but were hampered by limited sensitivity.

SPICA takes the next step in infrared observational capability by combining a large 2.5-meter diameter telescope, cooled to below 8 K, with instruments employing ultra-sensitive detectors. A combination of passive cooling and mechanical coolers will be used to cool both the telescope and the instruments. With mechanical coolers the mission lifetime is not limited by the supply of cryogen. With the combination of low telescope background and instruments with state-of-the-art detectors SPICA provides a huge advance on the capabilities of previous missions.

SPICA instruments offer spectral resolving power ranging from R ~50 through 11 000 in the 17–230 μm domain and R ~28.000 spectroscopy between 12 and 18 μm. SPICA will provide efficient 30–37 μm broad band mapping, and small field spectroscopic and polarimetric imaging at 100, 200 and 350 μm. SPICA will provide infrared spectroscopy with an unprecedented sensitivity of ~5 × 10−20 W m−2 (5σ/1 h)—over two orders of magnitude improvement over what earlier missions. This exceptional performance leap, will open entirely new domains in infrared astronomy; galaxy evolution and metal production over cosmic time, dust formation and evolution from very early epochs onwards, the formation history of planetary systems.

The mid-infrared range contains many spectral features associated with large molecules and dust grains such as polycyclic aromatic hydrocarbons and silicates. These are usually very strong compared to fine-structure gas lines, and thus valuable in studying the spectral properties of faint distant galaxies. In this paper, we evaluate the capability of low-resolution mid-infrared spectroscopic surveys of galaxies that could be performed by SPICA. The surveys are designed to address the question how star formation and black hole accretion activities evolved over cosmic time through spectral diagnostics of the physical conditions of the interstellar/circumnuclear media in galaxies. On the basis of results obtained with Herschel far-infrared photometric surveys of distant galaxies and Spitzer and AKARI near- to mid-infrared spectroscopic observations of nearby galaxies, we estimate the numbers of the galaxies at redshift z > 0.5, which are expected to be detected in the polycyclic aromatic hydrocarbon features or dust continuum by a wide (10 deg2) or deep (1 deg2) blind survey, both for a given observation time of 600 h. As by-products of the wide blind survey, we also expect to detect debris disks, through the mid-infrared excess above the photospheric emission of nearby main-sequence stars, and we estimate their number. We demonstrate that the SPICA mid-infrared surveys will efficiently provide us with unprecedentedly large spectral samples, which can be studied further in the far-infrared with SPICA.

IR spectroscopy in the range 12–230 μm with the SPace IR telescope for Cosmology and Astrophysics (SPICA) will reveal the physical processes governing the formation and evolution of galaxies and black holes through cosmic time, bridging the gap between the James Webb Space Telescope and the upcoming Extremely Large Telescopes at shorter wavelengths and the Atacama Large Millimeter Array at longer wavelengths. The SPICA, with its 2.5-m telescope actively cooled to below 8 K, will obtain the first spectroscopic determination, in the mid-IR rest-frame, of both the star-formation rate and black hole accretion rate histories of galaxies, reaching lookback times of 12 Gyr, for large statistically significant samples. Densities, temperatures, radiation fields, and gas-phase metallicities will be measured in dust-obscured galaxies and active galactic nuclei, sampling a large range in mass and luminosity, from faint local dwarf galaxies to luminous quasars in the distant Universe. Active galactic nuclei and starburst feedback and feeding mechanisms in distant galaxies will be uncovered through detailed measurements of molecular and atomic line profiles. The SPICA’s large-area deep spectrophotometric surveys will provide mid-IR spectra and continuum fluxes for unbiased samples of tens of thousands of galaxies, out to redshifts of z ~ 6.

Our current knowledge of star formation and accretion luminosity at high redshift (z > 3–4), as well as the possible connections between them, relies mostly on observations in the rest-frame ultraviolet, which are strongly affected by dust obscuration. Due to the lack of sensitivity of past and current infrared instrumentation, so far it has not been possible to get a glimpse into the early phases of the dust-obscured Universe. Among the next generation of infrared observatories, SPICA, observing in the 12–350 µm range, will be the only facility that can enable us to trace the evolution of the obscured star-formation rate and black-hole accretion rate densities over cosmic time, from the peak of their activity back to the reionisation epoch (i.e., 3 < z ≲ 6–7), where its predecessors had severe limitations. Here, we discuss the potential of photometric surveys performed with the SPICA mid-infrared instrument, enabled by the very low level of impact of dust obscuration in a band centred at 34 µm. These unique unbiased photometric surveys that SPICA will perform will fully characterise the evolution of AGNs and star-forming galaxies after reionisation.

The physical processes driving the chemical evolution of galaxies in the last ~ 11Gyr cannot be understood without directly probing the dust-obscured phase of star-forming galaxies and active galactic nuclei. This phase, hidden to optical tracers, represents the bulk of the star formation and black hole accretion activity in galaxies at 1 < z < 3. Spectroscopic observations with a cryogenic infrared observatory like SPICA, will be sensitive enough to peer through the dust-obscured regions of galaxies and access the rest-frame mid- to far-infrared range in galaxies at high-z. This wavelength range contains a unique suite of spectral lines and dust features that serve as proxies for the abundances of heavy elements and the dust composition, providing tracers with a feeble response to both extinction and temperature. In this work, we investigate how SPICA observations could be exploited to understand key aspects in the chemical evolution of galaxies: the assembly of nearby galaxies based on the spatial distribution of heavy element abundances, the global content of metals in galaxies reaching the knee of the luminosity function up to z ~ 3, and the dust composition of galaxies at high-z. Possible synergies with facilities available in the late 2020s are also discussed.

Ions that are moved by electric fields in gases follow quite exactly the electric field lines since these ions have substantially lost their kinetic energies in collisions with gas atoms or molecules and so carry no momenta. Shaping the electric fields appropriately the phase space such ion beams occupy can be reduced and correspondingly the ion density of beams be increased.

Extended abstract of a paper presented at Microscopy and Microanalysis 2012 in Phoenix, Arizona, USA, July 29 – August 2, 2012.

We present the first determination of the 18 μm luminosity function (LF) of galaxies at 0.006 < z < 0.7 (the average redshift is ~ 0.04) using the AKARI mid-infrared All-Sky Survey catalogue. We have selected a 18 μm flux-limited sample of 243 galaxies from the catalogue in the SDSS spectroscopic region. We then classified the sample into four types; Seyfert 1 galaxies (including QSOs), Seyfert 2 galaxies, LINERs and Star-Forming galaxies using mainly [OIII]/Hβ vs. [NII]/Hα line ratios obtained from the SDSS.

As a result of constructing Seyfert 1 and Seyfert 2 LFs, we found the following results; (i) the number density ratio of Seyfert 2s to Seyfert 1s is 3.98 ± 0.41 obtained from Sy1 and Sy2 LFs; this value is larger than the results obtained from optical LFs. (ii) the fraction of Sy2s in the entire AGNs may be anti-correlated with 18 μm luminosity. These results suggest that the torus structure probably depends on the mid-infrared luminosity of AGNs and most of the AGNs in the local Universe are obscured by dust.

The 7-valent pneumococcal conjugate vaccine (PCV7) is reported to decrease the incidence of community-acquired pneumonia (CAP) in children. To determine the annual incidence of CAP before the introduction of PCV7, we counted the number of children hospitalized with CAP between 2008 and 2009 in Chiba City, Japan. We investigated serotype and multilocus sequence typing (MLST) for Streptococcus pneumoniae isolates in CAP cases. The annual incidence of hospitalized CAP in children aged <5 years was 17·6 episodes/1000 child-years. In 626 episodes, S. pneumoniae was dominant in 14·7% and 0·8% of sputum and blood samples, respectively. The most common serotypes were 6B, 23F and 19F. The coverage rates of PCV7 were 66·7% and 80% in sputum samples and blood samples, respectively. MLST analysis revealed 37 sequence types. Furthermore, 54·1% of the sputum isolates and 40% of the blood isolate were related to international multidrug-resistant clones.

In order to realize the magnetic refrigeration system, it is necessary to develop a 100 W class refrigerator with COP > 7.5. This requires us to find new magnetic refrigerant materials, of which cooling capacity is 2.5 times higher than that of Gd. In this paper, first we discuss the cooling capacity of magnetic refrigerant materials to achieve COP = 7.5. Then, we compare the experimental results of MnAsSb, MnFe(PGe) and La(FeCoSi)13 compounds with the calculated cooling capacity. It is suggested that a composite layer material of MnFe(PGe) would show excellent cooling capacity in the temperature span of 20 K.

Crystallinity of area-selective Ge layer with a (0 0 1) surface grown on Si substrate has been investigated by means of diffractometry using a parallel X-ray microbeam. The measured lattice parameters of 〈0 0 1〉 direction were about 0.17% smaller than that of bulk Ge crystal. This tensile strain value was almost the same as the simulated ones that used the finite-element method.

The wettability of Pb-free Sn-based solder over the Cu-based Cu60Zr30Ti10 bulk metallic glass surface was investigated. We observed that the as-polished surface was nonwetting for the solder, which was due to the surface oxide layer of ZrOx formed in air. After complete removal of the oxide layer, a thin layer of Ag was deposited on the clean Cu60Zr30Ti10 surface. The Ag-covered Cu60Zr30Ti10 surface showed relatively high resistivity to the reoxidation even in air, and thus the wettability of the Cu60Zr30Ti10 surface for the Sn-based solder was greatly improved.

To investigate two clusters of diarrhoea cases observed in our geriatric hospital wards, the faecal specimens were analysed. Reversed passive latex agglutination assay revealed that 63·2% and 41·7% of the faecal specimens from each cluster were positive for Clostridium perfringens enterotoxin. PCR assay revealed that 71·4% and 68·8% of C. perfringens isolates from each cluster were positive for the enterotoxin gene (cpe). These observations suggested that both the clusters were outbreaks caused by enterotoxigenic C. perfringens. Subsequent pulsed-field gel electrophoresis analysis revealed that the two outbreaks were caused by different C. perfringens isolates. However, these outbreak isolates as well as other sporadic diarrhoea isolates shared a 75-kb plasmid on which the cpe gene and the tcp locus were located. The 75-kb plasmid had horizontally spread to various C. perfringens isolates and had caused outbreaks and sporadic infections. However, the site and time of the plasmid transfer are unclear.

Because of its applicability to biological specimens (nonconductors), a single-molecule-imaging technique, atomic force microscopy (AFM), has been particularly powerful for visualizing and analyzing complex biological processes. Comparative analyses based on AFM observation revealed that the bacterial nucleoids and human chromatin were constituted by a detergent/salt-resistant 30–40-nm fiber that turned into thicker fibers with beads of 70–80 nm diameter. AFM observations of the 14-kbp plasmid and 110-kbp F plasmid purified from Escherichia coli demonstrated that the 70–80-nm fiber did not contain a eukaryotic nucleosome-like “beads-on-a-string” structure. Chloroplast nucleoid (that lacks bacterial-type nucleoid proteins and eukaryotic histones) also exhibited the 70–80-nm structural units. Interestingly, naked DNA appeared when the nucleoids from E. coli and chloroplast were treated with RNase, whereas only 30-nm chromatin fiber was released from the human nucleus with the same treatment. These observations suggest that the 30–40-nm nucleoid fiber is formed with a help of nucleoid proteins and RNA in E. coli and chroloplast, and that the eukaryotic 30-nm chromatin fiber is formed without RNA. On the other hand, the 70–80-nm beaded structures in both E. coli and human are dependent on RNA.

In most of numerical simulations of spiral galaxy formation, mass/spatial resolution is ~ 105-6M๏ and kpc or sub-kpc, therefore inhomogeneous structure of the ISM in galaxies is not resolved. This is the most serious defect in simulating star formation and its feedback during galaxy formation/evolution. Here we show an intrinsic structures of the ISM using 3-D high resolution hydrodynamic simulations of galactic disks. We show that the PDFs in globally stable, inhomogeneous ISM in galactic disks are well fitted by a single log-normal function over a wide density range. The dispersion of the log-normal PDF (LN-PDF) is larger for more gas-rich systems. Using the LN-PDF, we give a generalized version of Schmidt-Kennicutt law, i.e. SFR as a function of average gas density, a critical local density for star formation, and star formation efficiency. We also introduce our new project, “Project Milky Way”, in which we aim to resolve properly the cold, dense ISM, as found in above simulations, by ultra-high resolution during galaxy formation. We are planning to construct a special cluster for simulating formation of “Milky Way” using the next generation GRAPE.

The AKARI (formerly known as ASTRO-F) mission is the first Japanese satellite dedicated for large area surveys in the infrared (Murakami et al. 2004). AKARI was launched successfully on February 22nd 2006 (JST) from JAXA's Uchinoura Space Centre, Japan. AKARI is now orbiting around the Earth in a Sun-synchronous polar orbit at the altitude of 700 km. The 68.5 cm aperture telescope and scientific instruments are cooled to 6K by liquid Helium and mechanical coolers. The expected liquid Helium holding time is now found to be at least one year after the successful aperture lid-opening on 2006 April 13th (JST). AKARI will perform the most advanced all-sky survey in 6 mid- to far-infrared wavebands since the preceding IRAS mission over 2 decades ago. Deep imaging and spectroscopic surveys near the ecliptic poles with pointed observations are also on-going in 13 wavelength bands at 2-160 μm (see Table 1, details are given in Matsuhara et al. 2006). AKARI is a perfect complement to Spitzer in respect of its wide sky area and wavelength coverage. Two unique aspects of the pointing deep surveys with AKARI are: many imaging bands including the wavelength gap of Spitzer (8-24 μm), and the slitless spectroscopic capability (Ohyama et al. in this proceeding). Not only the All-Sky Survey but also the deep pointing surveys near the ecliptic poles over ~15 deg2 in total will be particularly well suited to construct the luminosity functions of the infrared galaxies, to evaluate their clustering nature, and also to discover rare, exotic objects at various redshifts out to z ~ 3. AKARI is also capable of detecting and measuring the spectrum and the fluctuations of the cosmic infrared background. The in-orbit sensitivity and spatial resolution of the surveys are found to be sufficient to achive the scientific goals listed above.