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Multicriteria trajectory optimisation is expected to increase aviation safety, efficiency and environmental compatibility, although neither the theoretical calculation of such optimised trajectories nor their implementation into today’s already safe and efficient air traffic flow management reaches a satisfying level of fidelity. The calibration of the underlying objective functions leading to the virtually best available solution is complicated and hard to identify, since the participating stakeholders are very competitive. Furthermore, operational uncertainties hamper the robust identification of an optimised trajectory. These uncertainties may arise from severe weather conditions or operational changes in the airport management. In this study, the impact of multicriteria optimised free route trajectories on the air traffic flow management is analysed and compared with a validated reference scenario which consists of real flown trajectories during a peak hour of Europe’s complete air traffic in the upper airspace. Therefore, the TOolchain for Multicriteria Aircraft Trajectory Optimisation (TOMATO) is used for both the multicriteria optimisation of txrajectories and the calculation of the reference scenario. First, this paper gives evidence for the validity of the simulation environment TOMATO, by comparison of the integrated reference results with those of the commercial fast-time air traffic optimiser (AirTOp). Second, TOMATO is used for the multicriteria trajectory optimisation, the assessment of the trajectories and the calculation of their integrated impact on the air traffic flow management, which in turn is compared with the reference scenario. Thereby, significant differences between the reference scenario and the optimised scenario can be identified, especially considering the taskload due to frequent altitude changes and rescinded constraints given by waypoints in the reference scenario. The latter and the strong impact of wind direction and wind speed cause wide differences in the patterns of the lateral trajectories in the airspace with significant influence on the airspace capacity and controller’s taskload. With this study, the possibility of a successful 4D free route implementation into Europe’s upper airspace is proven even over central Europe during peak hours, when capacity constraints are already reaching their limits.
The lowland forest on the southern Pacific slope of Costa Rica has an extremely diverse avifauna, including the Black-cheeked Ant-tanager Habia atrimaxillaris. The only known remaining populations of this highly range-restricted species occur in the areas of Piedras Blancas and Corcovado National Park. It is assumed that the population is decreasing due to habitat loss and fragmentation. We assessed the species’ population density in a part of the Piedras Blancas National Park using distance sampling (in February–April 2009 and November 2010–January 2011) and territory mapping (November 2010–January 2011). We also examined habitat preferences based on vegetation structure at point count locations. Black-cheeked Ant-tanagers were exclusively found in old-growth forest. The species’ likelihood of occurrence at census points increased with forest cover (within a radius of 200 m around census points), canopy closure, and density of trees (with diameter at breast height >10 cm). Average population density estimated by distance sampling was 24–27 individuals per km², which is in accordance with the population size estimated by territory mapping (17–25 birds per km²). Based on these estimates, an overall population size of 12,432–20,720 birds is predicted for the remaining 592 km² lowland forest area of the Golfo Dulce region. The Black-cheeked Ant-tanager was only recorded in old-growth forest, but not in gallery forests embedded in a human-dominated landscape matrix. Since the species appears to avoid forest edges, further forest degradation and fragmentation will have a strong negative impact and should be rapidly reduced by adequate conservation measures.
The discovery of progesterone (P4) and elucidation of the mechanisms of P4 action have an important place in the history of endocrinology and reproduction. Circulating P4 concentration is determined by a balance between P4 production, primarily by the corpus luteum (CL), and P4 metabolism, primarily by the liver. The volume of luteal tissue and number and function of large luteal cells are primary factors determining P4 production. Rate of P4 metabolism is generally determined by liver blood flow and can be of critical importance in determining circulating P4 concentrations, particularly in dairy cattle. During timed artificial insemination (AI) protocols, elevations in P4 are achieved by increasing number of CL by creating accessory CL or by supplementation with exogenous P4. Dietary manipulations can also alter circulating P4, although practical methods to apply these techniques have not yet been reported. Elevating P4 before the timed AI generally decreases double ovulation and increases fertility to the timed AI. Near the time of AI, slight elevations in circulating P4, possibly due to inadequate luteal regression, can dramatically reduce fertility. After AI, circulating P4 is critical for embryo growth and establishment and maintenance of pregnancy. Many studies have attempted to improve fertility by elevating P4 after timed AI. Our recent meta-analysis and manipulative study indicated small fertility benefits (3% to 3.5%) mostly in primiparous cows. Thus, previous research has provided substantial insight into mechanisms regulating circulating P4 concentrations and actions. Understanding this prior research can focus future research on P4 manipulation to improve reproductive success.
Vagus nerve stimulation (VNS) therapy is associated with a decrease in seizure frequency in partial-onset seizure patients. Initial trials suggest that it may be an effective treatment, with few side-effects, for intractable depression.
Method
An open, uncontrolled European multi-centre study (D03) of VNS therapy was conducted, in addition to stable pharmacotherapy, in 74 patients with treatment-resistant depression (TRD). Treatment remained unchanged for the first 3 months; in the subsequent 9 months, medications and VNS dosing parameters were altered as indicated clinically.
Results
The baseline 28-item Hamilton Depression Rating Scale (HAMD-28) score averaged 34. After 3 months of VNS, response rates (⩾50% reduction in baseline scores) reached 37% and remission rates (HAMD-28 score <10) 17%. Response rates increased to 53% after 1 year of VNS, and remission rates reached 33%. Response was defined as sustained if no relapse occurred during the first year of VNS after response onset; 44% of patients met these criteria. Median time to response was 9 months. Most frequent side-effects were voice alteration (63% at 3 months of stimulation) and coughing (23%).
Conclusions
VNS therapy was effective in reducing severity of depression; efficacy increased over time. Efficacy ratings were in the same range as those previously reported from a USA study using a similar protocol; at 12 months, reduction of symptom severity was significantly higher in the European sample. This might be explained by a small but significant difference in the baseline HAMD-28 score and the lower number of treatments in the current episode in the European study.
Canadian Western Hard Red Spring (CWRS) wheat is recognized as premium quality wheat, ideal for breadmaking due to its superior milling qualities, baking characteristics and protein content. Organic wheat production is becoming more prevalent in Canada, due to increasing consumer demand for organic wheat products. Differences may exist in the baking and milling quality of wheat grown under conventional and organic management, a result of the dissimilarity between organic and conventional soil and crop management practices. Five CWRS cultivars released from 1885 to 1997 were grown under conventional and organic management and were assessed for their breadmaking potential. Several traits were investigated, including test weight, protein content, flour yield, kernel hardness and several mixograph parameters. Test weight was higher under conventional management, while no differences in protein content were observed between organic and conventionally grown wheat. Higher sodium dodecyl sulfate sedimentation (SDSS) volume, a reflection of gluten strength, was observed under conventional management, while there was a trend towards higher dough strength under organic management. Cultivars differed in grain protein, flour yield, kernel hardness and mixograph parameters, with Park and McKenzie superior to the others, particularly Red Fife, a much older cultivar. Management×cultivar interaction effects suggest that cultivars exhibit somewhat different baking characteristics when grown in the two management systems. There was no evidence that older cultivars (developed prior to the widespread use of pesticides and fertilizers) are better suited, in terms of breadmaking quality, for organic production.
The joint Nagra/JNC Radionuclide Retardation Programme has now been ongoing for 15 years with the main aim of direct testing of radionuclide transport models in as realistic a manner as possible. A large programme of field, laboratory and natural analogue studies has been carried out at the Grimsel Test Site in the central Swiss Alps and the Kamaishi In Situ Test Site in north-east Japan. The understanding and modelling of both the processes and the structures influencing radionuclide transport/retardation in fractured host rocks have matured as has the experimental technology, which has contributed to develop confidence in the applicability of the underlying research models in a repository performance assessment. In this paper, the successes and set-backs of this programme are discussed as is the general approach to the thorough testing of the process models and of model assumptions. In addition, a set of key findings is presented, involving discussions on the enhancement of confidence through the program.
The combination of self-organized growth on high-index substrates with lithographic patterning and atomic hydrogen assistance allows the fabrication of GaAs quantum wires and quantum dots as well as coupled wire-dot arrays with superior structural and electronic properties by molecular beam epitaxy. The selectivity of patterned growth on high-index substrates differs qualitatively from that on low-index ones thus producing quantum wire and quantum dot structures which fulfill the stringent criteria on the geometrical features to be met for useful devices.
The combination of self-organized growth on high-index substrates with lithographic patterning and atomic hydrogen assistance allows the fabrication of GaAs quantum wires and quantum dots as well as coupled wire-dot arrays with superior structural and electronic properties by molecular beam epitaxy. The selectivity of patterned growth on high-index substrates differs qualitatively from that on low-index ones thus producing quantum wire and quantum dot structures which fulfill the stringent criteria on the geometrical features to be met for useful devices.
In the region of Illapel, Chile, dioritic and andesitic rocks of Cretaceous to Paleocene age from the Unidad San Lorenzo Formation have suffered strong alteration resulting in the formation of a kaolin-rich zone, which is mined in the La Vanguardia open pit near Combarbalá. Detailed mineralogical and chemical investigations of channel samples from this mine, involving a combination of optical microscopy, XRD, SEM-EDX, XRF and TEM, permitted recognition of a zone of silicification and a zone of advanced argillic alteration, both of which contain alunite s.s. and aluminium-phosphate-sulphate (APS) minerals of the woodhouseite group with subordinate amounts of gorceixite, florencite and goyazite. These minerals are found to have originated from infiltration of meteoric waters. The passage from silicification into advanced argillic alteration was associated with an increase in sulphate activity as manifested by the increase of SO42— at the expense of PO43— in the alunite s.s. and by an increase of the Au content from 0.01 to 0.03 mg/kg Au. This high sulphidation type of wallrock alteration may be roughly compared with the Nansatu type of White (1991).
In the past several Wolf–Rayet stars have been investigated photometrically by different authors to search for fast pulsations. So far all results were negative. However, in 1992 Blecha, Schaller & Maeder published a 627sec period with a semi–amplitude of about 2.5mmag for the Southern Wolf–Rayet star WR40 (HD96548).
The long-term programme of in-situ radionuclide migration experiments in the underground test site at Grimsel (GTS) involves the development and testing of radionuclide transport models with their associated databases. The field experiments are carried out in a water-bearing shear zone in crystalline rock utilising a suite of tracers of differing geochemical behaviour. A rigorous model testing procedure has been developed for the GTS radionuclide migration experiment. This paper describes application of this testing procedure to a solute transport code developed by PNC.
We present a unified model for the detailed chemical evolution of individual elements from 12C to 56Fe and the photometric properties of galaxies via spectral evolutionary synthesis. Observations of narrow, heavy - element QSO absorption lines show an increase in the number of MgII systems per redshift interval for redshifts 0 <Zr ≤ 1.5 and a decrease in the number of CIV systems for 1.3 ≤ Zr ≤4.1. Both can be understood in terms of our galaxy evolution model accounting for SNI contributions which at the same time gives information about the structure of the Universe and about the IMF and star formation history in the intervening absorber galaxies. The spectrophotometric aspect of our unified model predicts spectral and photometric properties of these galaxies testable by optical identifications.
Evolutionary synthesis models have been computed to construct the spectral energy distributions of BCD galaxies in the optical and NIR ranges (0.3 to 3.5μm). Evolutionary tracks for stars having Z = 1/10 Z⊙ have been employed in order to match the observed low metal abundances of BCDs. Gaseous emission from H II regions has been included in the model. A starburst (of duration 5 · 106yr) is superimposed on an underlying component of red stars characterised by continuous star formation. Burst parameters, star formation rates and ionised hydrogen gas masses have been deduced by fitting the models to observed spectral energy distributions (SEDs) of BCDs.
One of the common uses of summability theory is found in its applications to power series. A partial listing such as [l]-[5], [13], and [15]-[17] might serve to remind us of the many instances of summability theory applied to power series. In some studies, the summability transformation is applied to the sequence of partial sums of the power series, while in others it is applied to the general term akzk as a series-to-series transformation. In [2] and [5] the transformation is applied to the coefficient sequence of the Taylor series. In the present study we investigate matrix transformations that are applied to the sequence {akzk), but we are not concerned with the usual preservation of convergence or sums. At a point within its disc of convergence, a power series exhibits more than ordinary convergence; it converges very rapidly, being dominated by a convergent geometric series.
Three-dimensional numerical solutions are obtained describing convection with a square lattice in a layer heated from below with no-slip top and bottom boundaries. The limit of infinite Prandtl number and a linear dependence of the viscosity on temperature are assumed. The stability of the three-dimensional solutions with respect to disturbances fitting the square lattice is analysed. It is shown that convection in the form of two-dimensional rolls is stable for low variations of viscosity, while square-pattern convection becomes stable when the viscosity contrast between upper and lower parts of the fluid layer is sufficiently strong. The theoretical results are in qualitative agreement with experimental observations.
Reactive sputter etching of SiO2 with CHF3-O2 plasmas has been investigated in a parallel plate reactor by combining etch rate measurements with concurrent determination of ion densities (using a Langmuir probe) and the composition of neutral plasma species (using a mass spectrometer). Etch rates are found to follow the ion density and to be fairly independent of the plasma chemistry under most experimental conditions. Moreover, a comparison of reactive sputter etching and reactive ion beam etching of SiO2 with CHF3 and CF4 shows that etch yields per incoming ion are essentially independent of the flux of neutral radicals to the substrate. This strongly suggests as the dominant etch mechanism for SiO2 direct reactive ion etching, where ions themselves are the main reactants in the etch reaction. Measured values of etch yields are consistent with this picture.
Three-dimensional solutions are computed describing convection in a layer of a Boussinesq fluid of infinite Prandtl number. Rigid boundaries of constant temperature are assumed. As many as four physically different solutions are found for a given rectangular horizontal periodicity interval. These are two solutions describing bimodal convection, and two ‘square-pattern’ solutions which correspond to two orthogonally superimposed convection rolls of nearly equal amplitude. The Galerkin method used in obtaining the steady solutions can also be employed for the investigation of their stability. The stability of the bimodal solutions agrees with the experimental determination of the stability region by Whithead & Chan (1976). The square-pattern solution is unstable in the investigated parameter range, even though it exhibits the highest Nusselt number.