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1 results

  • CD226 Gly307Ser Association With Neuromyelitis Optica in Southern Han Chinese

  • Chao Liu, Guansan Wang, Hong Liu, Yue Li, Jin Li, Yongqiang Dai, Xueqiang Hu
  • Journal:
    Canadian Journal of Neurological Sciences / Volume 39 / Issue 4 / July 2012
    Published online by Cambridge University Press:
    02 December 2014, pp. 488-490
    • Article
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  • Background:

    Neuromyelitis optica (NMO) and multiple sclerosis (MS) are autoimmune diseases of the central nervous system with complex pathogeneses. NMO was once considered to be a severe variant of MS. There has been more evidence that a non-synonymous exchange (rs763361/Gly307Ser) in the gene for CD226 is linked to several autoimmune diseases including multiple sclerosis (MS). However, no studies have investigated the role of rs763361 in the pathogenesis of NMO.

    Objectives:

    The goal of our study is to evaluate the role of CD226 Gly307Ser in neuromyelitis optica (NMO) in Southern Han Chinese.

    Methods:

    Eight-nine NMO patients, 93 relapsing-remitting multiple sclerosis (RRMS) patients, and 122 controls (CTLs) were enrolled. The rs763361 alleles of the subjects were determined by sequencing-based typing.

    Results:

    The results strongly support that the TT genotypes are associated with NMO but are not significantly correlated with susceptibility for MS.

    Conclusions:

    CD226 Gly307Ser may correlate with risk of NMO in Southern Han Chinese.