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1196 results

Page 1 of 60

  • Economic Impact of Redundant Antimicrobial Therapy in US Hospitals

  • Leslie Schultz, Timothy J. Lowe, Arjun Srinivasan, Dwight Neilson, Gina Pugliese
  • Journal:
    Infection Control & Hospital Epidemiology / Volume 35 / Issue 10 / October 2014
    Published online by Cambridge University Press:
    10 May 2016, pp. 1229-1235
    Print publication:
    October 2014
  • Background.

    Overutilization of antimicrobial therapy places patients at risk for harm and contributes to antimicrobial resistance and escalating healthcare costs. Focusing on redundant or duplicate antimicrobial therapy is 1 recommended strategy to reduce overutilization and its attendant effects on patient safety and hospital costs

    Objective.

    This study explored the incidence and economic impact of potentially redundant antimicrobial therapy.

    Methods.

    We conducted a retrospective analysis of inpatient administrative data drawn from 505 nonfederal US hospitals. All hospitalized patients discharged between January 1, 2008, and December 31, 2011, were eligible for study inclusion. Potentially redundant antimicrobial therapy was identified from pharmacy records and was defined as patients receiving treatment with overlapping antibiotic spectra for 2 or more consecutive days.

    Results.

    We found evidence of potentially inappropriate, redundant antimicrobial coverage for 23 different antimicrobial combinations in 394 of the 505 (78%) hospitals, representing a total of 32,507 cases. High-frequency redundancies were observed in 3 antianaerobic regimens, accounting for 22,701 (70%) of the cases. Of these, metronidazole and piperacillin-tazobactam accounted for 53% (n = 17,326) of all potentially redundant cases. Days of redundant therapy totaled 148,589, representing greater than $12 million in potentially avoidable healthcare costs.

    Conclusions.

    Our study suggests that there may be pervasive use of redundant antimicrobial therapy within US hospitals. Appropriate use of antimicrobials may reduce the risk of harm to patients and lower healthcare costs.

  • Nurses' Working Conditions Have Implications for Infectious Disease

  • Gina Pugliese, Martin S. Favero
  • Journal:
    Infection Control & Hospital Epidemiology / Volume 26 / Issue 3 / March 2005
    Published online by Cambridge University Press:
    21 June 2016, p. 328
    Print publication:
    March 2005
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  • Regulators Agree on Hallway Placement of Alcohol-Based Handrub

  • Gina Pugliese, Martin S. Favero
  • Journal:
    Infection Control & Hospital Epidemiology / Volume 26 / Issue 2 / February 2005
    Published online by Cambridge University Press:
    21 June 2016, p. 219
    Print publication:
    February 2005
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  • Are Hospital Surfaces Reservoirs for Nosocomial Infection?

  • Gina Pugliese, Martin S. Favero
  • Journal:
    Infection Control & Hospital Epidemiology / Volume 25 / Issue 12 / December 2004
    Published online by Cambridge University Press:
    02 January 2015, p. 1025
    Print publication:
    December 2004
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  • Aspergillus terreus Infections in Patients With Hematologic Malignancies

  • Gina Pugliese, Martin S. Favero
  • Journal:
    Infection Control & Hospital Epidemiology / Volume 25 / Issue 12 / December 2004
    Published online by Cambridge University Press:
    02 January 2015, p. 1082
    Print publication:
    December 2004
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  • Hand Hygiene Perceptions Among Physicians

  • Gina Pugliese, Martin S. Favero
  • Journal:
    Infection Control & Hospital Epidemiology / Volume 25 / Issue 11 / November 2004
    Published online by Cambridge University Press:
    02 January 2015, p. 917
    Print publication:
    November 2004
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Page 1 of 60