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Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools.
To examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics.
Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts.
Earlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = −0.34 years, s.e. = 0.08), major depression (β = −0.34 years, s.e. = 0.08), schizophrenia (β = −0.39 years, s.e. = 0.08), and educational attainment (β = −0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO.
AAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.
The Rapid ASKAP Continuum Survey (RACS) is the first large-area survey to be conducted with the full 36-antenna Australian Square Kilometre Array Pathfinder (ASKAP) telescope. RACS will provide a shallow model of the ASKAP sky that will aid the calibration of future deep ASKAP surveys. RACS will cover the whole sky visible from the ASKAP site in Western Australia and will cover the full ASKAP band of 700–1800 MHz. The RACS images are generally deeper than the existing NRAO VLA Sky Survey and Sydney University Molonglo Sky Survey radio surveys and have better spatial resolution. All RACS survey products will be public, including radio images (with
15 arcsec resolution) and catalogues of about three million source components with spectral index and polarisation information. In this paper, we present a description of the RACS survey and the first data release of 903 images covering the sky south of declination
made over a 288-MHz band centred at 887.5 MHz.
Party elites in coalition governments are acutely aware that the deals they strike will be critically evaluated by their supporters, and that they risk losing support if they are perceived as ineffective negotiators. This has a powerful influence on the bargains parties strike. Because most supporters are unaware of the complex aspects of bargains and instead rely on simple heuristics to evaluate their most visible features, parties have incentives to meet supporter expectations primarily on easily observable outcomes. To do so, they make trade-offs on less observable outcomes. This implies that the more visible features of a bargain typically do not accurately reflect the relative success of parties in coalition negotiations. We evaluate our argument using original data on the office rewards and policy risks of portfolio allocation in 16 parliamentary democracies. Our findings support our argument, and they have important implications for the nature of representation under multiparty government.
Childhood abuse and neglect are associated with dissociative symptoms in adulthood. However, empirical studies show heterogeneous results depending on the type of childhood abuse or neglect and other maltreatment characteristics. In this meta-analysis, we systematically investigated the relationship between childhood interpersonal maltreatment and dissociation in 65 studies with 7352 abused or neglected individuals using the Dissociative Experience Scale (DES). We extracted DES-scores for abused and non-abused populations as well as information about type of abuse/neglect, age of onset, duration of abuse, and relationship to the perpetrator. Random-effects models were used for data synthesis, and meta-regression was used to predict DES-scores in abused populations from maltreatment characteristics. The results revealed higher dissociation in victims of childhood abuse and neglect compared with non-abused or neglected subsamples sharing relevant population features (MAbuse = 23.5, MNeglect = 18.8, MControl = 13.8) with highest scores for sexual and physical abuse. An earlier age of onset, a longer duration of abuse, and parental abuse significantly predicted higher dissociation scores. This meta-analysis underlines the importance of childhood abuse/neglect in the etiology of dissociation. The identified moderators may inform risk assessment and early intervention to prevent the development of dissociative symptoms.
Recent research on parliamentary institutions has demonstrated that legislatures featuring strong committees play an important role in shaping government policy. However, the impact of the legislators who lead these committees – committee chairs – is poorly understood. This study provides the first examination of whether the partisan control of committee chairs in parliamentary systems has a systematic impact on legislative scrutiny. The article argues that committee chairs can, in principle, use their significant agenda powers to serve two purposes: providing opposition parties with a greater ability to scrutinize government policy proposals, and enabling government parties to better police one another. Analyzing the legislative histories of 1,100 government bills in three parliamentary democracies, the study finds that control of committee chairs significantly strengthens the ability of opposition parties to engage in legislative review. The analysis also suggests that government parties’ ability to monitor their coalition allies does not depend on control of committee chairs.
In a recent article in the Journal of Politics, Golder, Golder, and Siegel (2012) argue that models of government formation should be rebuilt “from the ground up.” They propose to do so with a “zero-intelligence” model of government formation. They claim that this model makes no theoretical assumptions beyond the requirement that a potential government, to be chosen, must be preferred by all its members and a legislative majority to the incumbent administration. They also claim that, empirically, their model does significantly better than existing models in predicting formation outcomes. We disagree with both claims. Theoretically, their model is unrestrictive in terms of its institutional assumptions, but it imposes a highly implausible behavioral assumption that drives the key results. Empirically, their assessment of the performance of the zero-intelligence model turns on data that are of limited relevance in testing coalition theories. We demonstrate that the predictions of the zero-intelligence model are no more accurate than random guesses, in stark contrast to the predictions of well-established approaches in traditional coalition research. We conclude that scholars would be ill-advised to dismiss traditional approaches in favor of the approach advanced by Golder, Golder, and Siegel.
We present preliminary results of the determination of fundamental parameters of single O-type stars in the MiMeS survey. We present the sample and we focus on surface CNO abundances, showing how they change as stars evolve off the zero-age main sequence.
The Randolph Glacier Inventory (RGI) is a globally complete collection of digital outlines of glaciers, excluding the ice sheets, developed to meet the needs of the Fifth Assessment of the Intergovernmental Panel on Climate Change for estimates of past and future mass balance. The RGI was created with limited resources in a short period. Priority was given to completeness of coverage, but a limited, uniform set of attributes is attached to each of the ~198 000 glaciers in its latest version, 3.2. Satellite imagery from 1999–2010 provided most of the outlines. Their total extent is estimated as 726 800 ± 34 000 km2. The uncertainty, about ±5%, is derived from careful single-glacier and basin-scale uncertainty estimates and comparisons with inventories that were not sources for the RGI. The main contributors to uncertainty are probably misinterpretation of seasonal snow cover and debris cover. These errors appear not to be normally distributed, and quantifying them reliably is an unsolved problem. Combined with digital elevation models, the RGI glacier outlines yield hypsometries that can be combined with atmospheric data or model outputs for analysis of the impacts of climatic change on glaciers. The RGI has already proved its value in the generation of significantly improved aggregate estimates of glacier mass changes and total volume, and thus actual and potential contributions to sea-level rise.
A large body of research has claimed that budget making by multiparty governments constitutes a “common pool resource” (CPR) problem that leads them to engage in higher levels of spending than single-party governments and, further, that this upwards fiscal pressure increases with the number of parties in the coalition. We offer a significant modification of the conventional wisdom. Drawing on recent developments in the literature on coalition governance, as well as research on fiscal institutions, we argue that budgetary rules can mitigate the CPR logic provided that they (1) reduce the influence of individual parties in the budget process and (2) generate endogenous incentives to resist spending demands by coalition partners. Our empirical evaluation, based on spending patterns in 15 European democracies over nearly 40 years, provides clear support for this contention. Restrictive budgetary procedures can eliminate the expansionary fiscal pressures associated with growing coalition size. Our conclusions suggest that there is room for addressing contemporary concerns over the size of the public sector in multiparty democracies through appropriate reforms to fiscal institutions, and they also have implications for debates about the merits of “proportional” and “majoritarian” models of democracy that are, at least in part, characterized by the difference between coalition and single-party governance.
Of the two authors of Dialektik der Aufklärung, Theodor W. Adorno is by far the more influential philosopher. Born in Frankfurt in 1903, he lived his first eleven years in the same street on which Arthur Schopenhauer had once resided. His father, Oscar Wiesengrund, owned a successful wine business; his mother, Maria Calvelli-Adorno della Piana, had been an opera singer. It was only when Adorno emigrated to America, in 1938, that he replaced the patronymic Wiesengrund with the less German-sounding surname taken from his mother. Maria's unmarried sister, Agathe, a well-known pianist, also lived with the family, and within this environment Adorno developed a passion for music. Indeed, for a while he even considered becoming a professional composer: in 1925, after having completed a PhD in philosophy at the tender age of twenty, he moved to Vienna to study composition with Alban Berg, who, like his master Arnold Schönberg, was among the most famous avant-garde composers of the day. But Adorno, though not without musical talent, lacked genuine creativity, and he soon returned to Frankfurt — and to philosophy. In this field, he possessed an originality and mental penetration matched by few. He never lost his interest in music, however, and a significant part of his oeuvre is devoted to the topic.
The Nazi ascent to power in 1933 robbed the Jewish philosopher of his teaching position at the University of Frankfurt and forced him into exile in Britain. He stayed there for the next five years — not, as he had hoped, as a university lecturer, but as a PhD student at Merton College, Oxford. His subsequent emigration to America was facilitated by Max Horkheimer.