We explore the long-term environmental and human history of a small outer coast archipelago on the Northwest Coast in western Canada. Using relative sea-level change, we reconstruct ancient landscapes to design archaeological surveys that document a rich archaeological record spanning at least 11 000 years and demonstrate the cultural centrality of this geographically marginal landscape.

BACKGROUND: IGTS is a rare phenomenon of paradoxical germ cell tumor (GCT) growth during or following treatment despite normalization of tumor markers. We sought to evaluate the frequency, clinical characteristics and outcome of IGTS in patients in 21 North-American and Australian institutions. METHODS: Patients with IGTS diagnosed from 2000-2017 were retrospectively evaluated. RESULTS: Out of 739 GCT diagnoses, IGTS was identified in 33 patients (4.5%). IGTS occurred in 9/191 (4.7%) mixed-malignant GCTs, 4/22 (18.2%) immature teratomas (ITs), 3/472 (0.6%) germinomas/germinomas with mature teratoma, and in 17 secreting non-biopsied tumours. Median age at GCT diagnosis was 10.9 years (range 1.8-19.4). Male gender (84%) and pineal location (88%) predominated. Of 27 patients with elevated markers, median serum AFP and Beta-HCG were 70 ng/mL (range 9.2-932) and 44 IU/L (range 4.2-493), respectively. IGTS occurred at a median time of 2 months (range 0.5-32) from diagnosis, during chemotherapy in 85%, radiation in 3%, and after treatment completion in 12%. Surgical resection was attempted in all, leading to gross total resection in 76%. Most patients (79%) resumed GCT chemotherapy/radiation after surgery. At a median follow-up of 5.3 years (range 0.3-12), all but 2 patients are alive (1 succumbed to progressive disease, 1 to malignant transformation of GCT). CONCLUSION: IGTS occurred in less than 5% of patients with GCT and most commonly after initiation of chemotherapy. IGTS was more common in patients with IT-only on biopsy than with mixed-malignant GCT. Surgical resection is a principal treatment modality. Survival outcomes for patients who developed IGTS are favourable.

Several instances a disastrous and even fatal effects to valuable pearorchards from being attacked by the Psylla have come under my observation, as well as entirely satisfactory results from treating the trees.

The life-history and habits of injurious insects must be accurately determined before we can know just how to deal with them. A knowledge of the habits of such insects will also often enable the farmer to so manage his land crops that the insects are placed under unfavourable and even destructive conditions.

Research in unconventional medicine requires a number of different questions to build up a “mosaic” of evidence. Choice of research design depends on the question being asked and is independent of the therapy under investigation. Despite the doubts of some practitioners, randomized trials are of value for determining certain questions in alternative medicine.

Whole grains are known to influence postprandial glucose response and insulin demand and are inversely associated with diabetes risk. Genetic variation of the transcription factor-7-like 2 encoding gene (TCF7L2) is assumed to promote an early insulin secretory defect and has been consistently attributed to the risk of developing type 2 diabetes. The present study examined the hypothesis that the protective effect of whole grains might be attenuated in the presence of the rs7903146 risk-conferring T-allele. We employed a case–cohort study of 2318 randomised individuals and 724 incident type 2 diabetes cases from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort. Multivariate Cox regression was used to estimate relative risks of diabetes including product terms testing for the genotype-specific effect modification of dietary whole grain. Dietary intake of whole grains was assessed by a validated FFQ. The TCF7L2 rs7903146 T-allele was associated with type 2 diabetes (hazard ratio = 1·51; 95 % CI 1·21, 1·87) and modified the inverse association between whole-grain intake and diabetes risk (P = 0·016 for interaction). While whole-grain intake was inversely associated with diabetes risk among rs7903146 CC homozygote carriers (hazard ratio for 50 g portion per d = 0·86; 95 % CI 0·75, 0·99), the T-allele negated the protective effect of whole-grain intake (hazard ratio among T-allele carriers for 50 g portion per d = 1·08; 95 % CI 0·96, 1·23). These data provide evidence that the beneficial effect of whole-grain intake on diabetes risk is modified by TCF7L2 rs7903146.

Fourier local correlation tracking (FLCT) was applied to time series of the normal magnetic field in vector magnetograms of NOAA AR 8210, from 17:13–21:29 UT on 1998 May 1, to derive photospheric flows. These flows, combined with both the observed horizontal magnetic field and an inferred horizontal potential magnetic field, can be used to derive the flux of free magnetic energy across the photosphere. Here, we present the formalism used, as well as a map of the time-averaged free energy flux. Over the time interval covered by the magnetograms, ${\sim} 10^{31}\,$erg of free magnetic energy flowed upward across the photosphere, a significant fraction of the energy typically released in large flares coronal mass ejections (CMEs). A flare and coronal mass ejection began at 22:30 UT. We acknowledge the kind support of AFOSR's MURI program.

The recommended post grazing stubble height for dairy cows in a rotational grazing system in spring is 8 to 10 cm. However, this height leads to much stem elongation and reduction in sward quality in mid and late season. Consequently, pastures require topping in June/July to maintain grass quality and reduce sward deterioration, particularly in rejected areas around dung pats. O'Riordan (1989) suggested that a leader/follower rotational grazing system with ewes following dairy cows could improve pasture utilisation and eliminate the need for topping. This was confirmed by Swift et al. (1991) who also demonstrated that grazing at one ewe with twin lambs per cow improved the utilisation of grass and allowed for acceptable ewe and lamb performance without apparently decreasing cow grazing days or milk output.

The objective of this work was to examine the effects of leader/follower rotational grazing with dairy cows and lambed ewes on grass tillering in a cool, wet western environment.

We discuss an ordinary differential equation which describes how the pressure in a coronal loop may evolve in time under the influence of a uniform, but time varying heating rate.

Solar flares are currently understood as the explosive release of energy stored in the form of stressed magnetic fields. In many cases, the released energy seems to take the form of large numbers of electrons accelerated to high energies (the nonthermal electron “thick target” model), or alternatively plasma heated to very high temperatures behind a rapidly moving conduction front (the “thermal” model). The transport of this energy into the remaining portion of the atmosphere results in violent mass motion and strong emission across the electromagnetic spectrum. Radiation processes play a crucial role in determining the ensuing plasma motion.

One important phenomenon observed during flares is the appearance in coronal magnetic loops of large amounts of upflowing, soft X-ray emitting plasma at temperatures of 1−2×107 [K]. It is believed that this is due to chromospheric evaporation, the process of heating cool (T - 104[K]) chromospheric material beyond its ability to radiate. Detailed calculations of thick target heating show that if nonthermal electrons heat the chromosphere directly, then the evaporation process can result in explosive upward motion of X-ray emitting plasma if the heating rate exceeds a threshold value. In such a case, upflow velocities approach an upper limit of roughly 2.35 cs as the heating rate is increased beyond the threshold, where cs is the sound speed in the evaporated plasma. This is known as explosive evaporation. If the flare heating rate is less than the threshold, evaporation takes place indirectly through thermal conduction of heat deposited in the corona by the energetic electrons. Upflows in this case are roughly 10 to 20% of the upper limit. Evaporation by thermal model heating always takes place through thermal conduction, and the computed upflow speeds seem to be about 10% to 20% of the upper limit, independent of the energy flux.

The pressure increase in the evaporated plasma for either the thick target or thermal model leads to a number of interesting phenomena in the flare chromosphere. The sudden pressure increase initiates a downward moving “chromospheric condensation”, an overdense region which gradually decelerates as it accretes material and propagates into the gravitationally stratified chromosphere. Solutions to an equation of motion for this condensation shows that its motion decays after about one minute of propagation into the chromosphere. When the front of this downflowing region is supersonic relative to the atmosphere ahead of it, a radiating shock will form. If the downflow is rapid enough, the shock strength should be sufficient to excite UV radiation normally associated with the transition region, and furthermore, the radiating shock will be brighter than the transition region. These results lead to a number of observationally testable relationships between the optical and ultraviolet spectra from the condensation and radiating shock.

I cannot begin this brief paper respecting our honored friend, the late President (who was also the founder) of this Society, without expressing my sense of personal bereavement in connection with his death. His unfailing vivacity, his amiable temper, his generous recognition of contemporary scholars in the same field with himself, and his loyal friendship, may well cause us to lament that his genial presence will no more be with us. He had long been a living, visible link, binding us to Germany, the land of scholars, the country which to many of us is an intellectual fatherland. Circumstances—or, what is the same thing, the leadings of Providence—conspired to fit him for that cosmopolitan place and versatile activity which characterized him. A Swiss by birth, but of German extraction, besides his early training in South Germany he studied at the three universities of Tübingen, Halle, and Berlin. Born and bred in the Reformed branch of the Protestant family, he was thus brought into intercourse in his youth with such men as Neander, Tholuck, and Müller, the great lights of the liberal, evangelical—I will not say party, for they were of no party, but class, among the Lutherans. His theological studies were not less diversified than his personal associations.

Of late the Alogi (so-called) have been the subject of renewed discussion in Germany. The topic is handled by Dr. A. Harnack in his able and elaborate article on “Monarchianism” in Herzogand Plitt's Encyclopædia (vol. x.), and in his “Dogmengeschichte” (second edition, 1888). It is considered at length in the first half of the first volume of Zahn's “History of the New Testament Canon” (1888). This last publication has called out a polemical review from Harnack, in which the Alogi forms one of the prominent themes. In Zahn's brief pamphlet in reply to Harnack, however, this particular topic is not taken up. The subject, as all are aware, is interesting as a branch of the history of Christology in the second century. It is especially important now for its connection with the debate respecting the authorship of the Fourth Gospel.