We examined the effect of biopesticides used alone, mixed with other biopesticides, or in conjunction with an imidacloprid against wireworms (Coleoptera: Elateridae) in spring wheat Triticum aestivum Linnaeus (Poaceae) (variety: Duclair). The study was conducted at Ledger and Valier, Montana, United States of America in 2015 and 2016. Ten biopesticides (spinosad, azadirachtin, pyrethrin, Beauveria bassiana (Balsamo-Crivelli) Vuillemin (Fungi: Clavicipitaceae) GHA (Mycotrol), B. bassiana ANT-03 (BioCeres), Chromobacterium subtsugae Martin et al. (Bacteria: Neisseriaceae), Burkholderia Yabuuchi et al. (Burkholderiaceae) species, Metarhizium brunneum Petch (Fungi: Clavicipitaceae) ESC1 (MbESC1), and M. brunneum F52 (MetF52) as microsclerotial and corn grit-based granules) were tested in addition to thimet and imidacloprid. Treatment efficacy was based on plant stand protection, wireworm populations, and yield. In 2015, there was considerable variation between sites in treatment efficacy. Mycotrol, BioCeres, MetF52+spinosad, and MetF52+imidacloprid applications protected seedlings from wireworm damage better than the control at Ledger, while only MetF52 at Valier. Wireworm populations were significantly higher with Mycotrol, spinosad, MetF52+spinosad, MbESC1 (25 g/L), and MetF52 treatments, compared with control, at 14 and 28 days post application at Ledger, but without effect at Valier, 2015. We found significantly higher yield in plots treated with imidacloprid+MetF52 and Mycotrol+azadirachtin (Xpulse) compared with control at Ledger. In 2016, no significant treatment effects were observed at either site. In summary, this study provides insight on what treatments should be explored in more detail despite variable results.