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In the course of the last few centuries the evolution of literature has been marked by the entry of Eastern countries into the system of social and spiritual relationships which came into being in the West at the beginning of the 17th century. This evolution is linked with the changes which have been grouped together as “modernization.” The content of this modernization coincides, more or less, with what Marx and Engels described, in the first chapter of the Communist Manifesto, as the expansion of the bourgeoisie. However, in the 20th century, the possibility of a non-capitalist path has become apparent, and therefore the theory of modernization gives a wider sense to the character of the ruling class (which, in the 19th century, was the European bourgeoisie), and emphasizes changes of a general nature: the differentiation of the social structure, the birth of new institutions and new roles, economic differentiation, industrialization, urbanization, increased vertical and horizontal mobility, cultural differentiation, the birth of a science independent of religion, the substitution of a businesslike, rational attitude to life for a religious one, the development of civic awareness and of civil rights. The cradle of modernization (England, Holland, France) is conventionally called “the West.” Other countries, including those situated to the west of France (e.g. Spain, Portugal) are considered as “the non-West.”
The question posed in the title of this article requires us to indicate exactly what we mean by medieval India. Does there exist in general an Indian Middle Ages? Or rather are the Middle Ages a purely European category, and the extension of it to include India involve extrapolations that are devoid of sense?
We aimed to evaluate the effect of yoga on motor and non-motor symptoms and cortical excitability in patients with Parkinson’s disease (PD).
Methods:
We prospectively evaluated 17 patients with PD at baseline, after one month of conventional care, and after one month of supervised yoga sessions. The motor and non-motor symptoms were evaluated using the Unified Parkinson’s disease Rating Scale (motor part III), Hoehn and Yahr stage, Montreal Cognitive Assessment, Hamilton depression rating scale, Hamilton anxiety rating scale, non-motor symptoms questionnaire and World Health Organization quality of life questionnaire. Transcranial magnetic stimulation was used to record resting motor threshold, central motor conduction time, ipsilateral silent period (iSP), contralateral silent period (cSP), short interval intracortical inhibition (SICI), and intracortical facilitation.
Results:
The mean age of the patients was 55.5 ± 10.8 years, with a mean duration of illness of 4.0 ± 2.5 years. The postural stability of the patients significantly improved following yoga (0.59 ± 0.5 to 0.18 ± 0.4, p = 0.039). There was a significant reduction in the cSP from baseline (138.07 ± 27.5 ms) to 4 weeks of yoga therapy (116.94 ± 18.2 ms, p = 0.004). In addition, a significant reduction in SICI was observed after four weeks of yoga therapy (0.22 ± 0.10) to (0.46 ± 0.23), p = 0.004).
Conclusion:
Yoga intervention can significantly improve postural stability in patients with PD. A significant reduction of cSP and SICI suggests a reduction in GABAergic neurotransmission following yoga therapy that may underlie the improvement observed in postural stability.
BOUT++ turbulence simulations were performed to investigate the impact of turbulence spreading on the edge localized mode (ELM) size and divertor heat flux width $({\lambda _q})$ broadening in small ELM regimes. This study is motivated by EAST experiments. BOUT++ linear simulations of a pedestal radial electric field (Er) scan show that the dominant toroidal number mode (n) shifts from high-n to low-n, with a narrow mode spectrum, and the maximum linear growth rate increases as the pedestal Er well deepens. The nonlinear simulations show that as the net E × B pedestal flow increases, the pressure fluctuation level and its inward penetration beyond the top of the pedestal both increase. This leads to a transition from small ELMs to large ELMs. Both inward and outward turbulence spreading are sensitive to the scrape-off-layer (SOL) plasma profiles. The inward turbulence spreading increases for the steep SOL profiles, leading to increasing pedestal energy loss in the small ELM regime. The SOL width $({\lambda _q})$ is significantly broadened progressing from the ELM-free to small ELM regime, due to the onset of strong radial turbulent transport. The extent of the SOL width $({\lambda _q})$ broadening depends strongly on outward turbulence spreading. The fluctuation energy intensity flux ${\varGamma _\varepsilon }$ at the separatrix can be enhanced by increasing either pedestal Er flow shear or local SOL pressure gradient. The ${\lambda _q}$ is broadened as the fluctuation energy intensity flux ${\varGamma _\varepsilon }$ at the last close flux surface (LCFS) increases. Local SOL E × B flow shear will restrain outward turbulence spreading and the associated heat flux width broadening. Operating in H-mode with small ELMs has the potential to solve two critical problems: reducing the ELM size and broadening the SOL width.
A conducting cylinder with a uniform magnetic field along its axis and radial temperature gradient is considered at the stationary state. At large temperature gradients the azimuthal Hall electrical current creates an axial magnetic field whose strength may be comparable with the original one. It is shown that the magnetic field, generated by the azimuthal Hall current, leads to the decrease of a magnetic field originated by external sources, and this suppression increases with an increase of the electromotive force, connected with thermodiffusion. Obtained results can help to investigate the influence of the Hall current on the coupled magnetothermal evolution of magnetic and electric fields in neutron stars, white dwarfs and, possibly, in laboratory facilities.
Decompressive craniectomy is part of the acute management of several neurosurgical illnesses, and is commonly followed by cranioplasty. Data are still scarce on the functional and cognitive outcomes following cranioplasty. We aim to evaluate these outcomes in patients who underwent cranioplasty following traumatic brain injury (TBI) or stroke.
Methods:
In this prospective cohort, we assessed 1-month and 6-month neuropsychological and functional outcomes in TBI and stroke patients who underwent cranioplasty at a Brazilian tertiary center. The primary outcome was the change in the Digits Test at 1 and 6 months after cranioplasty. Repeated measures general linear models were employed to assess the patients' evolution and interactions with baseline characteristics. Effect size was estimated by the partial η2.
Results:
A total of 20 TBI and 14 stroke patients were included (mean age 42 ± 14 years; 52.9% male; average schooling 9.5 ± 3.8 years; 91.2% right-handed). We found significant improvements in the Digits Tests up to 6 months after cranioplasty (p = 0.004, partial η2 = 0.183), as well as in attention, episodic memory, verbal fluency, working memory, inhibitory control, visuoconstructive and visuospatial abilities (partial η2 0.106–0.305). We found no interaction between the cranioplasty effect and age, sex or schooling. Patients submitted to cranioplasty earlier (<1 year) after injury had better outcomes.
Conclusion:
Cognitive and functional outcomes improved after cranioplasty following decompressive craniectomy for stroke or TBI. This effect was consistent regardless of age, sex, or education level and persisted after 6 months. Some degree of spontaneous improvement might have contributed to the results.
We utilize resolvent and weakly nonlinear analyses in combination with direct numerical simulations (DNS) to identify mechanisms for oblique transition in a Mach $5$ hypersonic flow over an adiabatic slender double wedge. Even though the laminar separated flow is globally stable, resolvent analysis demonstrates significant amplification of unsteady external disturbances to the linearized flow equations. These disturbances are introduced upstream of the separation zone and they lead to the appearance of oblique waves further downstream. We demonstrate that the large amplification of oblique waves arises from the growth of fluctuation shear stress due to streamline curvature of the laminar base flow in the separated shear layer. This is in contrast to the attached boundary layers, where no such mechanism exists. We also use a weakly nonlinear analysis to show that the resolvent operator associated with linearization around the laminar base flow governs the evolution of steady reattachment streaks that arise from quadratic interactions of unsteady oblique waves. These quadratic interactions generate vortical excitations in the reattaching shear layer which lead to the formation of streaks in the recirculation zone and their subsequent amplification, breakdown and transition to turbulence downstream. Our analysis of the energy budget shows that deceleration of the base flow near reattachment is primarily responsible for amplification of steady streaks. Finally, we employ DNS to examine latter stages of transition to turbulence and demonstrate the predictive power of a weakly nonlinear input–output framework in uncovering triggering mechanisms for oblique transition in separated high-speed boundary layer flows.
“Identity, Agency, Motion: Taylor's Twelvepence and the Poetry of Commodity” examines John Taylor's 1621 curious poem A Shilling or, the Travailes of Twelve-pence as a record of one keen observer's attempt to grapple with the rapidly changing social and economic dimensions of seventeenth century London. The essay argues that as the poem re-imagines the shilling as a person with a life history and agency of its own, it bears witness to a human world increasingly defined by relations with money and marked by the weakening of social ties (exemplified by the slavery that haunts the twelvepence's travels). The humanizing and centring of the coin provokes a dehumanizing and de-centring of its human servants, including the poet himself.
Keywords: coins, pamphlet literature, early modern economy, materialism
John Taylor's 1621 comic work A Shilling or, The Travailes of Twelve-Pence – first printed and distributed in pamphlet form and later included in All the Workes of John Taylor – presents a series of conceits, alternately funny and moralistic, describing the “life” of money (in the world, in England, and especially in London). The 1621 pamphlet, which would have been cheap to buy and read by an increasingly literate public, includes a brief advertisement, a frontispiece with a short explanatory poem (“The Meaning of the Picture”), a letter to the reader (“To the Reader”), and the 910-line poem itself (“The Travels of Twelve-Pence”). While the most impressive explosion of cheap print did not occur for another 20 years, Taylor's text may have had a quite varied readership. In The Marketplace of Print, Alexandra Halasz explains that cheap pamphlets behaved like printed gossip, and that “[t]he development of the marketplace [for cheap print] coincides with the rise of the vernacular as a religious and literate language and an increase in literacy not to be equalled until the eighteenth century, at least in England.” Deborah Valenze notes that we can judge the pamphlet's popularity by the many imitations it engendered.
The poem is an amusing jumble, a grab-bag of extended metaphors, catalogues, and semi-philosophical reflections, a collection of poems enjambed uncomfortably into a single dizzying, disjointed stanza only very occasionally divided by horizontal lines.
When a fluid stream in a conduit splits in order to pass around an obstruction, it is possible that one branch will be critically controlled while the other remains not so. This is apparently the situation in Pacific Ocean abyssal circulation, where most of the northward flow of Antarctic bottom water passes through the Samoan Passage, where it is hydraulically controlled, while the remainder is diverted around the Manihiki Plateau and is not controlled. These observations raise a number of questions concerning the dynamics necessary to support such a regime in the steady state, the nature of upstream influence and the usefulness of rotating hydraulic theory to predict the partitioning of volume transport between the two paths, which assumes the controlled branch is inviscid. Through the use of a theory for constant potential vorticity flow and accompanying numerical model, we show that a steady-state regime similar to what is observed is dynamically possible provided that sufficient bottom friction is present in the uncontrolled branch. In this case, the upstream influence that typically exists for rotating channel flow is transformed into influence into how the flow is partitioned. As a result, the partitioning of volume flux can still be reasonably well predicted with an inviscid theory that exploits the lack of upstream influence.
In the present study, the nematicidal activity of a Moringa oleifera ethyl acetate leaf extract against the eggs and larvae of Haemonchus contortus and Nacobbus aberrans, nematodes of agricultural importance, was evaluated. The experimental design for the evaluation of the effects against both nematodes consisted of eight treatments (n = 4). Distilled water, Tween (4%) and a commercial anthelmintic agent (ivermectin, 5 mg/mL) were used as controls, and for treatments 4–8, the concentrations of the extract were 20, 10, 5, 2.5 and 1.25 mg/mL, respectively. Readings were taken at 12 h and 24 h for N. aberrans and 48 h and 72 h for H. contortus post-treatment under an optical microscope (10× and 40×). The data obtained were analysed by analysis of variance through a completely randomized factorial design using the SAS V9 program. The results show that, for H. contortus egg hatching, 85.88% inhibition was obtained at a concentration of 20 mg/mL at 48 h, while for third-stage larva (L3) mortality, the highest percentage was 68.19% at 1.25 mg/mL at 72 h. In the case of N. aberrans, the greatest inhibition of egg hatching was 90.69% at 5 mg/mL at 12 h post-treatment, and for larval mortality, it was 100% at 10 mg/mL at 24 h post-treatment. The main major compounds identified by qualitative analysis and by gas chromatography coupled to mass spectrometry were 9,12,15-octadecatrienoic acid, (Z,Z,Z)-, n-hexadecanoic acid and 2,4-di-tert-butylphenol, and the minor compounds included phytol, γ-sitosterol and α-tocopheryl acetate. It was demonstrated that the ethyl acetate leaf extract of M. oleifera Lam. shows great potential for combating agricultural nematodes.
Firm operators continually manage multiple sources of risk. In an application to cattle feedlot operations, our objective is to determine if producers view output price and animal health risks separately or jointly. We conduct a survey with a choice experiment placing operators in forward looking, decision-making scenarios, and capture information on past risk management approaches. Evidence regarding a relationship between animal health and output price risk mitigation is mixed and depends on the decision being made. Combined, these results provide new insight into how managers approach multiple risks when facing resource constraints.
To establish flutter onset boundaries on the flight envelope, it is required to determine the flutter onset dynamic pressure. Proper selection of a flight flutter prediction technique is vital to flutter onset speed prediction. Several methods are available in literature, starting with those based on velocity damping, envelope functions, flutter margin, discrete-time Autoregressive Moving Average (ARMA) modelling, flutterometer and the Houbolt–Rainey algorithm. Each approach has its capabilities and limitations. To choose a robust and efficient flutter prediction technique from among the velocity damping, envelope function, Houbolt–Rainey, flutter margin and auto-regressive techniques, an example problem is chosen for their evaluation. Hence, in this paper, a three-degree-of-freedom model representing the aerodynamics, stiffness and inertia of a typical wing section is used(1). The aerodynamic, stiffness and inertia properties in the example problem are kept the same when each of the above techniques is used to predict the flutter speed of this aeroelastic system. This three-degree-of-freedom model is used to generate data at speeds before initiation of flutter, during flutter and after occurrence of flutter. Using these data, the above-mentioned flutter prediction methods are evaluated and the results are presented.
The main goal of this work was to evaluate the in vitro biological activity of two ferrocenyl chalcones (FcC-1 and FcC-2) against Haemonchus contortus (third-stage larvae (L3)) and Nacobbus aberrans (second-stage juveniles (J2)). Both compounds were synthesized and characterized by usual spectroscopic methods and their molecular structures were confirmed by single-crystal X-ray diffractometry. Nematode strains were examined in terms of percentage mortality of H. contortus (L3) by the action of FcC-1, which showed an effectivity of 100% at a concentration of 342 μM in 24 h, with EC50 = 20.33 μM and EC90 = 162.76 μM, whereas FcC-2 had an effectivity of 72% at a concentration of 342 μM in 24 h, with EC50 = 167.39 μM and EC90 = 316.21 μM. The effect of FcC-1 against nematode phytoparasite N. aberrans showed a better percentage of 95% at a concentration of 342 μM, with EC50 = 7.18 μM and EC90 = 79.25 μM, whereas the effect of FcC-2 was 87% at 342 μM, with EC50 = 168 μM and EC90 = 319.56 μM at 36 h. After treatment, the scanning electron micrographs revealed deformities in the dorsal flank and posterior part close to the tail of H. contortus L3. They showed moderate in vitro nematicidal activity against H. contortus L3 and N. aberrans J2.
The aims of this study were to evaluate changes in inflammatory and oxidative stress levels following treatment with N-acetylcysteine (NAC) or mitochondrial-enhancing agents (CT), and to assess the how these changes may predict and/or moderate clinical outcomes primarily the Montgomery-Åsberg Depression Rating Scale (MADRS).
Methods:
This study involved secondary analysis of a placebo-controlled randomised trial (n = 163). Serum samples were collected at baseline and week 16 of the clinical trial to determine changes in Interleukin-6 (IL-6) and total antioxidant capacity (TAC) following adjunctive CT and/or NAC treatment, and to explore the predictability of the outcome or moderator effects of these markers.
Results:
In the NAC-treated group, no difference was observed in serum IL-6 and TAC levels after 16 weeks of treatment with NAC or CT. However, results from a moderator analysis showed that in the CT group, lower IL-6 levels at baseline was a significant moderator of MADRS χ2 (df) = 4.90, p = 0.027) and Clinical Global Impression-Improvement (CGI-I, χ2 (df) = 6.28 p = 0.012). In addition, IL-6 was a non-specific but significant predictor of functioning (based on the Social and Occupational Functioning Assessment Scale (SOFAS)), indicating that individuals with higher IL-6 levels at baseline had a greater improvement on SOFAS regardless of their treatment (p = 0.023).
Conclusion:
Participants with lower IL-6 levels at baseline had a better response to the adjunctive treatment with the mitochondrial-enhancing agents in terms of improvements in MADRS and CGI-I outcomes.