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We have employed the VULCAN laser facility to generate a laser plasma X-ray source for use in photoionization experiments. A nanosecond laser pulse with an intensity of order 1015 Wcm−2 was used to irradiate thin Ag or Sn foil targets coated onto a parylene substrate, and the L-shell emission in the 3.3–4.4 keV range was recorded for both the laser-irradiated and nonirradiated sides. Both the experimental and simulation results show higher laser to X-ray conversion yields for Ag compared with Sn, with our simulations indicating yields approximately a factor of two higher than those found in the experiments. Although detailed angular data were not available experimentally, the simulations indicate that the emission is quite isotropic on the laser-irradiated side but shows close to a cosine variation on the nonirradiated side of the target as seen experimentally in the previous work.
The interaction of relativistically intense lasers with opaque targets represents a highly non-linear, multi-dimensional parameter space. This limits the utility of sequential 1D scanning of experimental parameters for the optimization of secondary radiation, although to-date this has been the accepted methodology due to low data acquisition rates. High repetition-rate (HRR) lasers augmented by machine learning present a valuable opportunity for efficient source optimization. Here, an automated, HRR-compatible system produced high-fidelity parameter scans, revealing the influence of laser intensity on target pre-heating and proton generation. A closed-loop Bayesian optimization of maximum proton energy, through control of the laser wavefront and target position, produced proton beams with equivalent maximum energy to manually optimized laser pulses but using only 60% of the laser energy. This demonstration of automated optimization of laser-driven proton beams is a crucial step towards deeper physical insight and the construction of future radiation sources.
We present the development and characterization of a high-stability, multi-material, multi-thickness tape-drive target for laser-driven acceleration at repetition rates of up to 100 Hz. The tape surface position was measured to be stable on the sub-micrometre scale, compatible with the high-numerical aperture focusing geometries required to achieve relativistic intensity interactions with the pulse energy available in current multi-Hz and near-future higher repetition-rate lasers ($>$kHz). Long-term drift was characterized at 100 Hz demonstrating suitability for operation over extended periods. The target was continuously operated at up to 5 Hz in a recent experiment for 70,000 shots without intervention by the experimental team, with the exception of tape replacement, producing the largest data-set of relativistically intense laser–solid foil measurements to date. This tape drive provides robust targetry for the generation and study of high-repetition-rate ion beams using next-generation high-power laser systems, also enabling wider applications of laser-driven proton sources.
Refractory depression is a devastating condition with significant morbidity, mortality, and societal cost. Approximately 15% of patients with major depressive disorder are refractory to currently available treatments. We hypothesized metabolic abnormalities contributing to treatment refractory depression are associated with distinct findings identifiable in the cerebrospinal fluid (CSF). Our hypothesis was confirmed by a previous small case-controlled study. Here we present a second, larger replication study.
Methods
We conducted a case-controlled, targeted, metabolomic evaluation of 141 adolescent and adult patients with well-characterized history of depression refractory to three maximum-dose, adequate-duration medication treatments, and 36 healthy controls. Plasma, urine, and CSF metabolic profiling were performed by coupled gas chromatography/mass spectrometry, and high-performance liquid chromatography, electrospray ionization, tandem mass spectrometry.
Results
Abnormalities were identified in 67 of 141 treatment refractory depression participants. The CSF abnormalities included: low cerebral folate (n = 20), low tetrahydrobiopterin intermediates (n = 11), and borderline low-tetrahydrobiopterin intermediates (n = 20). Serum abnormalities included abnormal acylcarnitine profile (n = 12) and abnormal serum amino acids (n = 20). Eighteen patients presented with two or more abnormal metabolic findings. Sixteen patients with cerebral folate deficiency and seven with low tetrahydrobiopterin intermediates in CSF showed improvement in depression symptom inventories after treatment with folinic acid and sapropterin, respectively. No healthy controls had a metabolite abnormality.
Conclusions
Examination of metabolic disorders in treatment refractory depression identified an unexpectedly large proportion of patients with potentially treatable abnormalities. The etiology of these abnormalities and their potential roles in pathogenesis remain to be determined.
In 2011, the Royal College of Psychiatrists in UK published a five-year plan to boost recruitment to a 95% fill rate for core training posts. Psychiatric summer schools were one of the methods outlined to improve recruitment. These are 3-day courses allowing attendees to explore different subspecialties and showcase inspiring psychiatrists who are leaders in their field.
Aims
To evaluate whether attending a Psychiatry Summer School improves scores on the attitudes towards Psychiatry Scale (ATP-30) in Medical Students (MS) and Junior Doctors (JD).
Methods
Two free courses were held; one for MS in August 2016 and one for JD in November 2015. These involved interactive talks from consultant psychiatrists in various sub-specialties and a day in a forensic setting. All attendees were asked to complete ATP-30 before and immediately after attendance. A higher ATP-30 score indicates a more positive the attitude the minimum score is 30 and the maximum is 50. Paired scores were analysed using a paired t-test.
Results
Thirty-three out of 45 attendees completed ATP-30 MS (n = 20/24) and JD (n = 13/21) before and after the course. The mean ATP30 score was 116 before attendance and 128 after the course, the mean difference was +12. When the two samples were compared using a paired t-test, there was a significant positive difference P < 0.0005.
Conclusions
Psychiatry summer schools can improve attitudes towards psychiatry in medical students and junior doctors.
Disclosure of interest
The authors have not supplied their declaration of competing interest.
We use displacements derived from matching complex synthetic aperture radar data using maximum coherence to generate a dense network of velocity estimates over the Amery Ice Shelf. From these velocities we generate the horizontal strain-rate components and resolve them with respect to the local flow direction. We present the spatial distributions of velocity and transverse shear strain rate and use them to investigate features of the flow regime for the shelf. From the southern end of the shelf, velocity decreases from a high of about 800ma–1 to around 300 ma–1, and then increases to a maximum of about 1350ma–1 at the centre of the front. Strain rates vary systematically across and along the shelf. The pattern of the transverse shear strain rate clearly identifies the shear margins, where values exceed 0.1 a–1 in the southern section of the shelf. The pattern also shows longitudinal bands of enhanced shear strain rate containing ice with a strong preferred crystal fabric that was advected from shear margins upstream. In the northern section of the shelf, significant values of longitudinal and traverse stresses lead to enhanced shear deformation through their effect on the octahedral shear stress term.
In the spring of 1995 an extensive global positioning system (GPS) survey was carried out on the Amery Ice Shelf, East Antarctica, providing ground-truth ellipsoidal height measurements for the European remote-sensing satellite (ERS) radar altimeters. GPS- and altimeter-derived surface heights have been compared at the intersecting points of the ERS ground tracks and the GPS survey. The mean and rms height difference for all ERS-1 geodetic-phase tracks across the survey region is 0.0 + 0.1 m and 1.7 m, respectively. The spatial distribution of the height differences is highly correlated with surface topographic variations. Comparisons of GPS-derived surface-elevation profiles along ERS ground tracks show that the ERS altimeters can closely follow the GPS representation of the actual surface.
A survey of icebergs using satellite radar images has been made in the seasonal sea-ice zone of East Antarctica in the .sector between longitudes 50° and 145° E. These data provide information on the spatial distribution and size statistics of icebergs near the coast in areas not often visited by shipboard observers, and close to their sources at ice shelves and glacier tongues. The icebergs are detected and their dimensions extracted by analysis of the texture properties present in satellite images acquired with ERS-1 synthetic aperture radar during the austral winter. The minimum size of iceberg reliably detected and measured is 0.06 km2.
A significant variation, by up to a factor of two, is found in the area of icebergs close to different sections of the coast, which suggests a characteristic size for different sources. The average value of the length-to-width ratio for icebergs in the whole population shows some variability with size. The probability of finding icebergs is greatest close to the coast, decreasing in general with distance from the coast, such that few icebergs were detected more than 160 km from the coast. in one sector about 85° E, icebergs are found to at least 550 km from the coast, which is consistent with the transport of icebergs northwards in this region by a branch of the westward-heading near-coastal current (East Wind Drift) which connects with the southern margins of the eastward-heading Antarctic Circumpolar Current.
We have constructed theoretical spherical dust shell models using a full radiative transfer treatment, to investigate the effect of thermal emission on the strengths of molecular CO and H2O features in late type stars with circumstellar dust shells and to establish the optical depth at which the strengths of the bands are significantly affected. In this study, for the first time the central sources have been represented by realistic atmospheric models for cool stars in the temperature range 2500–3000 K, which are representative of the central stars of OH/IR sources. Parameters of the dust shell models were chosen to fit the observed run of colours from 1.25–5 μm of a large sample of OH/IR sources using ‘dirty silicate opacities’. The results show that the molecular band strengths in the 2 μm region are significantly affected by the dust emission only when the optical depth in the shell reaches a value of τ1μm ≈2 for T* = 2500 K and somewhat less for T* = 3000 K. However, the changes are such that the distinction between supergiant-like spectra, and variable M-star spectra is retained in models with very high shell optical depths. The implications of these models are discussed in relation to previous observations of OH/IR sources.
The Parkes radio telescope has been used to search a list of small, dense southern dark clouds and Bok globules for ammonia emission at 23.7 GHz. The ammonia observations, together with IRAS data and the cloud’s visual appearance, have been used to determine a short list of dark clouds for observation with the infrared imaging system (IRIS) on the Anglo-Australian Telescope, in an attempt to determine the dust density distribution within the clouds. Near-infrared images of a number of the short listed clouds have been obtained with IRIS at J, H and K’. Preliminary results are reported for this ammonia survey, together with IRIS images of the strong ammonia source DC 297.7–2.8. Coincident with the dense ammonia core of this object is an IRAS ‘core’ source, IRAS 11590–6452 and an extremely interesting near-infrared source, which lies on the edge of the error ellipse of the IRAS source.
Molecular ices are a common component of the dust in many molecular clouds and circumstellar shells. The most abundant molecule, H2O, has several infrared spectral features which have strongly temperature dependent shapes (FWHM) and peak wavelengths. This paper describes how a study of these features, both astronomically and in the laboratory, can lead to constraints on the temperatures of interstellar dust grains. This is demonstrated in part by comparing several astronomical spectra with laboratory spectra of H2O ice.
Our knowledge of the universe comes from recording the photon and particle fluxes incident on the Earth from space. We thus require sensitive measurement across the entire energy spectrum, using large telescopes with efficient instrumentation located on superb sites. Technological advances and engineering constraints are nearing the point where we are recording as many photons arriving at a site as is possible. Major advances in the future will come from improving the quality of the site. The ultimate site is, of course, beyond the Earth’s atmosphere, such as on the Moon, but economic limitations prevent our exploiting this avenue to the degree that the scientific community desires. Here we describe an alternative, which offers many of the advantages of space for a fraction of the cost: the Antarctic Plateau.
Ultracompact H II regions are small, dense regions of ionised gas surrounding high-mass stars which are still embedded in their natal molecular clouds. A survey of such regions has been commenced in an attempt to improve our understanding of the processes of high-mass star formation. The initial stages of the survey have involved selection of likely candidates from the IRAS Point Source Catalogue, correlation with radio continuum emission at 4·85 GHz and subsequent observations of methanol maser emission at 6·668 GHz. Preliminary results of the methanol maser survey are given.
A laboratory astrophysics facility for the study of the terrestrial analogues of interstellar dust grains is being developed in the Physics Department, University College, Australian Defence Force Academy. The facility consists of a gas handling system for the preparation of samples, a closed-cycle cooler and specimen chamber, and a Fourier Transform Infrared (FTIR) Spectrometer capable of high resolution (0.3 cm−1) and high sensitivity measurements, currently from 1-25 μm. The layout and construction of the laboratory are described, and the proposed initial experimental program aimed at determining the optical constants of ices over a wide wavelength range for comparison with astronomical observations is discussed.
There is growing evidence for the notion that large grains are an important constituent of the interstellar medium. It has been found to be necessary to invoke the presence of large grains (of radius a > 1.0 μm) in a number of circumstellar shells, including those around Eta Carinae, and some late type giants and supergiants. Most recently, as a result of IRAS observations, the same idea has been used in the interpretation of the extensive optically thin disks found around some young early type stars. It is important to establish size constraints on these grains, so as to determine better the probable mix of interstellar grains. Previous work on AG Carinae suggested merely that the grains in the circumstellar shell need to be larger than 1 μm, but gave no information regarding the maximum size which would be acceptable. In this paper, we explore the question of the characteristic size of the dust grains in the AG Carinae shell, by fitting the spatially integrated model energy distribution to observations over the wavelength range 360 nm–100 μm, and conclude that silicate grains of radius ~ 1.0 μm give a satisfactory fit to the spectrum and angular distribution, but that grains appreciably larger or smaller than this radius are unsatisfactory.
We describe the characteristics of a series of thin film tin oxide films grown by plasma-assisted molecular beam epitaxy on r-plane sapphire substrates over a range of flux and substrate temperature conditions. A mixture of both SnO2 and SnO are detected in several films, with the amount depending on growth conditions, most particularly the substrate temperature. Electrical measurements were not possible on all samples due to roughness related issues with contacting, but at least one film exhibited p-type characteristics depending on measurement conditions, and one sample exhibited significant persistent photoconductivity upon ultraviolet excitation in a metal-semiconductor-metal device structure.