Since 2004, at the Laboratoire d'Astrophysique de Toulouse Tarbes (LATT), we work with CMOS APSdetectors, firstly to develop a large-field,high-resolution camerafor the observation of the solar supergranulation, secondlyto develop a fast camera for an adaptive optics test bench.In these two projects, we use detectors from FillFactory, now continued byCypress Semiconductor Corporation: IBIS4-14000, IBIS-16000, LUPA-4000,14 Mpixels, 16 Mpixels, 4 Mpixels respectively. The last one just readsin a 240 × 240 pixels window to obtain readout rate of 1000 Image/s.For these purposes we developed dedicated controllers to followthe high pixel rate and multi-output readout of this type of detectors.We also studied the characterization methods and measuredthe main parameters of these CMOS detectors to know their behaviour. Usingthese kinds of APS detectors in these two particular projects provesthat we can already find niches to use CMOS detectors in astronomy takingadvantage of their present specificities. Recent improvements likeback illumination, noise reduction, should rapidly open news possibilities.