A greenhouse experiment was conducted from 1995 to 1996 to determine the inheritance of ALS-cross-resistant common cocklebur. Two known biotypes (ALS-susceptible and ALS-resistant) were used in the experiment. Susceptible biotypes were crossed with pollen from resistant biotypes. F1 plants were self-pollinated. F2 plants were sprayed postemergence (POST) with a tank mixture of imazaquin at 280 g ai/ha and chlorimuron at 18 g ai/ha. Three distinct responses were observed: (1) no apparent effect (resistant), (2) yellowing of leaves with live terminals (intermediate), and (3) yellow leaves with dead terminals (typical symptoms of an ALS-susceptible common cocklebur). Chi-square tests indicated that an incomplete dominance model did not fit the data. Responses one and two were, therefore, combined and chi-square tests indicated a complete dominance model fit the data. This indicates that the cross-resistant trait is a dominant to semidominant trait.