This paper presents a two-elements based, dual polarized, single layer, patch antenna array with improved isolation between transmit (Tx) and receive (Rx) ports for 2.4 GHz in-band full duplex (IBFD) or simultaneous transmit and receive wireless applications. The differential feeding deployed at the Rx port effectively suppresses the coupling which is termed as self-interference from the Tx port to achieve high Tx–Rx interport isolation. A simple 3 dB/180° ring hybrid coupler with nice amplitude and phase balance characteristics has been used for differential Rx operation. The mathematical description for a differential feeding based self-interference cancellation mechanism is also presented for the proposed dual polarized IBFD antenna array. The measurement results for the implemented prototype of the antenna array demonstrate very nice levels of Tx–Rx interport isolation. The implemented single layer, compact antenna array presents 10 dB return-loss bandwidth of more than 50 MHz for both Tx and Rx ports. The prototype achieves >80 dB peak interport isolation and 75 dB (65 dB) isolation in 20 MHz (50 MHz) bandwidth.