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The endocrine and neuroendocrine system in pregnancy involves highly complex maternal, fetal and placental mechanisms, which are critical for the maintenance of pregnancy, the timing of parturition, for fetal growth and protection from adverse fetal programming. This timely book summarizes the different endocrine aspects related to pregnant women, describing how hormones regulate physiological homeostasis and influence the pathogenesis of disease. The first section of the book covers the role of specific hormones in detail, including oxytocin, hCG and estrogen. The second section discusses gestational disorders such as diabetes, hypertensive disorders and preeclampsia and how the involvement of hormones has clinical implications for management. Best practice for management of endocrine disorders, which can negatively impact pregnancy, such as thyroid disease and obesity, is also reviewed. This book is essential for clinicians and scientists looking to gain knowledge of the role of hormones in pregnancy and how they can best support patients.
Gestational Diabetes (GDM) is the most common metabolic disorder of pregnancy, and it is associated with short and long term adverse outcome for the mother and the offspring. The prevalence of GDM is growing rapidly worldwide in association with pandemic obesity and rising maternal age, but controversy still remains over screening and diagnostic criteria. This chapter describes normal metabolic modification in pregnancy and GDM physiopathology, maternal and offspring complication, diagnosis, and management.